Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2412746..2414337 Replicon chromosome
Accession NZ_CP025225
Organism Enterobacter cancerogenus strain CR-Eb1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag CWI88_RS11550 Protein ID WP_101737716.1
Coordinates 2412746..2414080 (-) Length 445 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag CWI88_RS11555 Protein ID WP_101737717.1
Coordinates 2414080..2414337 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CWI88_RS11535 2408834..2409739 + 906 WP_101737713.1 LysR family transcriptional regulator -
CWI88_RS11540 2409976..2410341 + 366 WP_101737714.1 hypothetical protein -
CWI88_RS11545 2410390..2412444 + 2055 WP_101737715.1 pyrroloquinoline quinone-dependent dehydrogenase -
CWI88_RS11550 2412746..2414080 - 1335 WP_101737716.1 type II toxin-antitoxin system HipA family toxin Toxin
CWI88_RS11555 2414080..2414337 - 258 WP_101737717.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
CWI88_RS11560 2414455..2415213 - 759 WP_042319819.1 DeoR/GlpR family DNA-binding transcription regulator -
CWI88_RS11565 2415300..2415884 + 585 WP_006175284.1 hydrolase YffH -
CWI88_RS11570 2415970..2416728 + 759 WP_101737718.1 trans-aconitate 2-methyltransferase -
CWI88_RS11575 2416737..2417927 - 1191 WP_101737719.1 cytochrome c biogenesis protein/redoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-68)


Sequences

Toxin        


Download         Length: 445 a.a.        Molecular weight: 49498.84 Da        Isoelectric Point: 8.1535

>T89907 WP_101737716.1 NZ_CP025225:c2414080-2412746 [Enterobacter cancerogenus]
MPTLVTWMNNERVGELTKLPTGAHTYRYDKTWLSSPYARPLSLSLPLQTGNITSDAVFNFFDNLLPDSPVVRDRIVKRYQ
AKSKQPFDLLAEIGRDSVGAVTLLPPEEASLNPVMAWETLSEQKLEAILSAYKSDIPLGMIDDENDFRISVAGAQEKTAL
LKKGDDWCIPKGTTPTTHIIKLPIGEIRQPNATLDLRDSVDNEYFCLKFASALGFEVPKAEIIKAGRVRALAVERFDRRW
NADHTVLLRLPQEDMCQTFGLPSSLKYESDGGPGIAQIMSFLLGSSAALKDRHNFMKFQVFQWLLGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGAGIHISDLKLAMGLTATRGRKNAIDKIHPRHFMATAKAVKFPEDRMREMMQSFANHVP
QAIDEVMDSLPEGFSDKVATSITSNVRRLHARLCVKRLENERSG

Download         Length: 1335 bp

>T89907 NZ_CP025225:c2414080-2412746 [Enterobacter cancerogenus]
ATGCCGACATTAGTGACATGGATGAATAACGAACGCGTCGGTGAACTGACGAAATTGCCAACCGGCGCACATACGTACAG
GTATGACAAAACGTGGCTTTCAAGCCCGTACGCCCGACCTTTGTCGTTATCTCTGCCGCTGCAAACCGGTAATATCACCT
CCGATGCCGTTTTTAACTTCTTTGATAACCTCCTGCCGGACAGTCCTGTCGTCAGGGATCGTATCGTGAAGCGCTATCAG
GCGAAATCTAAACAACCTTTTGATTTACTTGCAGAAATAGGTCGCGACAGCGTGGGCGCCGTGACGTTACTGCCGCCAGA
AGAAGCGAGCCTGAATCCGGTCATGGCCTGGGAAACGCTCAGCGAGCAGAAGCTGGAAGCAATCCTCTCGGCCTATAAAT
CCGATATTCCACTGGGGATGATTGATGACGAAAATGATTTTCGCATTTCCGTCGCCGGCGCCCAGGAAAAGACGGCGTTA
TTAAAGAAGGGAGATGACTGGTGCATCCCGAAAGGCACGACGCCAACGACCCATATCATTAAGTTGCCGATCGGCGAAAT
CAGGCAGCCTAACGCTACGCTGGATTTACGCGACAGCGTCGATAACGAATATTTCTGCCTCAAGTTCGCAAGCGCACTGG
GTTTTGAGGTGCCGAAAGCGGAAATCATCAAGGCGGGCAGAGTGCGCGCGCTTGCCGTGGAACGCTTCGACAGGCGCTGG
AATGCAGACCACACCGTTTTACTGCGGCTGCCTCAGGAAGATATGTGTCAGACATTCGGACTGCCTTCCTCGTTAAAGTA
CGAATCCGACGGTGGCCCCGGCATTGCGCAAATCATGTCATTTTTACTCGGCTCTAGCGCTGCACTGAAAGATCGCCACA
ACTTTATGAAGTTCCAGGTGTTTCAGTGGCTGTTGGGCGCAACCGACGGCCATGCTAAAAATTTCTCGGTATTTATACAG
GCGGGCGGAAGTTATCGGCTGACGCCATTTTATGACATCATCTCGGCATTCCCGGTACTCGGTGGCGCCGGTATTCACAT
CAGCGATTTGAAACTGGCAATGGGCCTGACGGCAACCAGGGGCCGAAAAAATGCCATCGATAAAATTCATCCGCGCCATT
TTATGGCAACTGCAAAAGCGGTGAAGTTCCCGGAGGATCGGATGAGAGAGATGATGCAGTCGTTCGCAAATCACGTCCCG
CAGGCGATTGACGAGGTTATGGATTCGCTGCCGGAAGGTTTTTCCGACAAGGTGGCGACGTCGATAACGTCCAACGTACG
CCGATTGCATGCGCGTTTATGTGTAAAGAGGTTGGAAAATGAGCGATCTGGGTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9602.94 Da        Isoelectric Point: 6.4571

>AT89907 WP_101737717.1 NZ_CP025225:c2414337-2414080 [Enterobacter cancerogenus]
MKAPMIYSPTQLANAMRLVRQKNNWTQSELAKKIGIKQATISNFENAPDNTTLATFFKILQSLEMSVSLHEADHAVADNP
QELDW

Download         Length: 258 bp

>AT89907 NZ_CP025225:c2414337-2414080 [Enterobacter cancerogenus]
ATGAAAGCACCCATGATATACAGCCCGACGCAGCTGGCGAACGCCATGAGGCTGGTTCGCCAAAAAAACAACTGGACCCA
GAGTGAGCTGGCAAAAAAGATAGGCATTAAGCAGGCGACGATTTCCAATTTTGAAAATGCCCCGGACAATACCACGCTGG
CGACGTTTTTTAAAATACTCCAGTCGCTTGAGATGAGCGTGTCTTTGCACGAAGCAGACCATGCGGTTGCCGATAATCCA
CAGGAGCTGGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References