Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 1361593..1362191 Replicon chromosome
Accession NZ_CP025225
Organism Enterobacter cancerogenus strain CR-Eb1

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag CWI88_RS06470 Protein ID WP_101737202.1
Coordinates 1361811..1362191 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag CWI88_RS06465 Protein ID WP_088207982.1
Coordinates 1361593..1361814 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CWI88_RS06445 1357593..1358816 + 1224 WP_006176577.1 alanine transaminase -
CWI88_RS06450 1358873..1358944 - 72 WP_099458937.1 membrane protein YpdK -
CWI88_RS06455 1359302..1360219 - 918 WP_042320354.1 kdo(2)-lipid IV(A) palmitoleoyltransferase -
CWI88_RS06460 1360595..1361275 + 681 WP_101737201.1 DNA-binding protein -
CWI88_RS06465 1361593..1361814 + 222 WP_088207982.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CWI88_RS06470 1361811..1362191 + 381 WP_101737202.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
CWI88_RS06475 1362506..1362865 - 360 WP_101737203.1 tyrosine-type recombinase/integrase -
CWI88_RS06490 1363411..1364340 - 930 WP_101737205.1 formate/nitrite transporter family protein -
CWI88_RS06495 1364657..1365409 + 753 WP_006176573.1 phospholipid-binding lipoprotein MlaA -
CWI88_RS06500 1365455..1366783 - 1329 WP_042320348.1 long-chain fatty acid transporter FadL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(4-116)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14182.21 Da        Isoelectric Point: 6.2297

>T89898 WP_101737202.1 NZ_CP025225:1361811-1362191 [Enterobacter cancerogenus]
MKWISAQEVIAFHDRILRYLPGVAGMPDAGRADAIIYRVQNRAHYEGVNNIFELAATYWVAIARGHIFNDENKRTSFFVT
MAFLRRNGVLVLDEGTELEELTVQAATGEKTVEQLSAILRTLAIQS

Download         Length: 381 bp

>T89898 NZ_CP025225:1361811-1362191 [Enterobacter cancerogenus]
ATGAAATGGATTAGCGCCCAGGAGGTTATTGCATTTCATGACCGTATATTGCGTTATCTTCCCGGCGTAGCCGGTATGCC
TGATGCCGGGAGAGCCGACGCCATTATCTACCGTGTCCAGAACCGCGCCCATTACGAAGGCGTAAATAACATTTTCGAAC
TGGCTGCAACGTATTGGGTTGCCATTGCTCGTGGACACATTTTTAACGACGAGAACAAGCGTACATCGTTCTTTGTCACA
ATGGCGTTTTTGCGCCGCAACGGTGTGCTGGTCTTAGACGAAGGAACAGAACTGGAAGAATTAACCGTTCAGGCCGCAAC
CGGTGAAAAAACAGTAGAGCAACTCTCCGCGATTTTGCGCACCCTGGCGATCCAATCCTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8051.01 Da        Isoelectric Point: 5.0190

>AT89898 WP_088207982.1 NZ_CP025225:1361593-1361814 [Enterobacter cancerogenus]
MITYTSTQARANISAVLESATSGEPVEITRRDGSAAVVISKAEFEAYQAAKLDDEFDFIMQRHGRTIKALTDR

Download         Length: 222 bp

>AT89898 NZ_CP025225:1361593-1361814 [Enterobacter cancerogenus]
ATGATTACCTATACATCAACGCAGGCCAGAGCCAATATCTCAGCAGTTTTAGAAAGTGCTACCAGCGGAGAGCCGGTAGA
GATTACACGGCGGGATGGTTCGGCGGCTGTCGTTATCAGCAAGGCTGAGTTTGAGGCATATCAGGCAGCGAAGCTGGATG
ATGAGTTTGATTTCATCATGCAACGGCATGGCAGAACCATCAAGGCGCTAACTGACCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References