Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 856626..857283 Replicon chromosome
Accession NZ_CP025225
Organism Enterobacter cancerogenus strain CR-Eb1

Toxin (Protein)


Gene name cptA Uniprot ID A0A5Q2KE30
Locus tag CWI88_RS04105 Protein ID WP_058608592.1
Coordinates 856873..857283 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W7NX65
Locus tag CWI88_RS04100 Protein ID WP_006178375.1
Coordinates 856626..856892 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CWI88_RS04080 852046..853479 - 1434 WP_101737026.1 6-phospho-beta-glucosidase -
CWI88_RS04085 853595..854326 - 732 WP_101738561.1 MurR/RpiR family transcriptional regulator -
CWI88_RS04090 854593..855252 + 660 WP_006178378.1 hemolysin III family protein -
CWI88_RS04095 855351..856331 - 981 WP_101737027.1 tRNA-modifying protein YgfZ -
CWI88_RS04100 856626..856892 + 267 WP_006178375.1 FAD assembly factor SdhE Antitoxin
CWI88_RS04105 856873..857283 + 411 WP_058608592.1 protein YgfX Toxin
CWI88_RS04110 857291..857812 - 522 WP_006178373.1 flavodoxin FldB -
CWI88_RS04115 857914..858810 + 897 WP_006178372.1 site-specific tyrosine recombinase XerD -
CWI88_RS04120 858839..859552 + 714 WP_006178371.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
CWI88_RS04125 859558..861291 + 1734 WP_058608590.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16190.97 Da        Isoelectric Point: 11.1724

>T89897 WP_058608592.1 NZ_CP025225:856873-857283 [Enterobacter cancerogenus]
VVLWQSELRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDIIGTPWMLNSGMMLRLRSVDGERRQHLWLAADSMDAAEWRDLRRTMLQQPTQD

Download         Length: 411 bp

>T89897 NZ_CP025225:856873-857283 [Enterobacter cancerogenus]
GTGGTCCTGTGGCAATCTGAACTTCGCGTCTCATGGCGCTCGCAGTGGATGTCTTTATTGCTCCACGGCCTGGTGGCGGC
CTTTGTACTACTGATGCCGTGGCCCCTTAGCTACACGCCTCTGTGGTTGCTGCTGCTGTCATTTGTAGTGTTTGACAGCG
TGCGCAGCCAGCGCCGGATTAATGCCCGTCAGGGTGAGATCAAACTGCTGATGGATTCCCGCCTGCGCTGGCAGGGAAAA
GAGTGGGACATCATCGGTACGCCGTGGATGCTCAATTCCGGCATGATGCTGCGCTTGCGAAGCGTGGATGGAGAGCGTCG
CCAGCACCTGTGGCTGGCGGCTGACAGTATGGACGCTGCTGAGTGGCGGGATCTGCGCCGGACGATGTTGCAGCAGCCGA
CGCAGGATTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10569.05 Da        Isoelectric Point: 5.1340

>AT89897 WP_006178375.1 NZ_CP025225:856626-856892 [Enterobacter cancerogenus]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT89897 NZ_CP025225:856626-856892 [Enterobacter cancerogenus]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGTATGCGTGAACTTGATATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGACACCCTGAGCGACGACGATAAGCGGCTCTTTGTGCGCCTGCTCGAATCAGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Q2KE30

Antitoxin

Source ID Structure
AlphaFold DB W7NX65

References