Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 2635207..2635841 Replicon chromosome
Accession NZ_CP025223
Organism Enterococcus sp. CR-Ec1

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag CXM95_RS12645 Protein ID WP_086297585.1
Coordinates 2635207..2635557 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag CXM95_RS12650 Protein ID WP_176285365.1
Coordinates 2635551..2635841 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CXM95_RS12615 2630867..2632228 - 1362 WP_005225442.1 hypothetical protein -
CXM95_RS12620 2632578..2633501 - 924 WP_086297582.1 peptide-methionine (S)-S-oxide reductase MsrA -
CXM95_RS12630 2633818..2634363 - 546 WP_042890449.1 cysteine hydrolase -
CXM95_RS12635 2634466..2634891 + 426 WP_016613640.1 AsnC family transcriptional regulator -
CXM95_RS12640 2634973..2635191 + 219 Protein_2415 helix-turn-helix domain-containing protein -
CXM95_RS12645 2635207..2635557 - 351 WP_086297585.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
CXM95_RS12650 2635551..2635841 - 291 WP_176285365.1 PbsX family transcriptional regulator Antitoxin
CXM95_RS12655 2636101..2636268 - 168 WP_016621416.1 PTS glucose transporter subunit IIA -
CXM95_RS12660 2636614..2636712 - 99 WP_074534955.1 type I toxin-antitoxin system Fst family toxin -
CXM95_RS12665 2636800..2637558 - 759 WP_086297604.1 type I methionyl aminopeptidase -
CXM95_RS12670 2637601..2638338 - 738 WP_005225435.1 tRNA pseudouridine(38-40) synthase TruA -
CXM95_RS12675 2638404..2638883 - 480 WP_008379108.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
CXM95_RS12680 2639257..2640561 + 1305 WP_086297606.1 trypsin-like peptidase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-111)

Antitoxin

Antitoxin PemI-like

(13-96)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13118.10 Da        Isoelectric Point: 8.0524

>T89894 WP_086297585.1 NZ_CP025223:c2635557-2635207 [Enterococcus sp. CR-Ec1]
MVRKPRQGDILLLDTAPRSGHEQTGKRPYIVLSHDMIADYSNVATVAPISSTSRNYPLYVSIDPDYGMKTTGKVLLDQLT
TIDYEARACVFLEKAHEHLVDELLIKVRTVFQKVSR

Download         Length: 351 bp

>T89894 NZ_CP025223:c2635557-2635207 [Enterococcus sp. CR-Ec1]
ATGGTAAGAAAACCTAGACAAGGTGATATTTTGTTATTGGATACAGCTCCTCGTTCTGGACATGAACAAACGGGAAAAAG
GCCCTATATTGTTTTAAGTCATGACATGATTGCAGATTATAGTAACGTTGCCACCGTTGCTCCGATTTCGAGTACAAGTA
GAAACTATCCGTTATATGTAAGTATTGATCCAGATTATGGCATGAAGACAACAGGAAAAGTATTGTTGGATCAATTAACG
ACAATTGATTATGAAGCCAGAGCATGTGTTTTTTTGGAAAAAGCGCATGAGCACTTGGTTGATGAGTTATTGATAAAAGT
TAGAACAGTATTTCAAAAAGTAAGTAGATAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 11270.90 Da        Isoelectric Point: 4.9450

>AT89894 WP_176285365.1 NZ_CP025223:c2635841-2635551 [Enterococcus sp. CR-Ec1]
MYIQKEVSRMEMLPIKKWGNSNGLRLPKYIMEYLGIHTDDKVKIIQEEVNGHKRLIIEAANLENELTIEELFENYTAEKN
HVEIQNLGEAVGNEKW

Download         Length: 291 bp

>AT89894 NZ_CP025223:c2635841-2635551 [Enterococcus sp. CR-Ec1]
ATGTATATACAGAAAGAGGTGTCGCGCATGGAAATGTTACCTATAAAAAAATGGGGCAATAGTAACGGTCTGAGATTGCC
GAAGTACATTATGGAGTATCTTGGCATTCATACAGATGACAAAGTGAAGATAATACAAGAAGAAGTAAACGGCCATAAAC
GGCTAATCATCGAAGCAGCAAATTTAGAAAACGAGTTAACGATTGAAGAGTTATTTGAAAATTACACTGCTGAGAAAAAT
CATGTGGAAATTCAAAATTTAGGTGAAGCAGTAGGGAATGAAAAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References