Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 17897..18423 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP025212 | ||
| Organism | Klebsiella pneumoniae strain HZW25 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | CW753_RS26360 | Protein ID | WP_000323025.1 |
| Coordinates | 17897..18184 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | CW753_RS26365 | Protein ID | WP_000534858.1 |
| Coordinates | 18184..18423 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CW753_RS26305 (CW753_26475) | 12951..13229 | - | 279 | WP_004152721.1 | helix-turn-helix transcriptional regulator | - |
| CW753_RS26310 (CW753_26480) | 13219..13539 | - | 321 | WP_094833316.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| CW753_RS26315 (CW753_26485) | 13620..13844 | - | 225 | WP_020325128.1 | hypothetical protein | - |
| CW753_RS26320 (CW753_26490) | 13855..14067 | - | 213 | WP_020325129.1 | hypothetical protein | - |
| CW753_RS26325 (CW753_26495) | 14128..14484 | - | 357 | WP_004152717.1 | hypothetical protein | - |
| CW753_RS26335 (CW753_26505) | 15120..15470 | - | 351 | WP_004182068.1 | hypothetical protein | - |
| CW753_RS26340 (CW753_26510) | 15467..15739 | - | 273 | WP_023317525.1 | hypothetical protein | - |
| CW753_RS26345 (CW753_26515) | 15929..16414 | + | 486 | WP_020277937.1 | hypothetical protein | - |
| CW753_RS26350 (CW753_26520) | 16579..16680 | - | 102 | Protein_22 | DUF5431 family protein | - |
| CW753_RS30040 | 16644..16736 | - | 93 | Protein_23 | Hok/Gef family protein | - |
| CW753_RS26355 (CW753_26525) | 16796..17830 | + | 1035 | Protein_24 | IS481 family transposase | - |
| CW753_RS26360 (CW753_26530) | 17897..18184 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| CW753_RS26365 (CW753_26535) | 18184..18423 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| CW753_RS30045 | 18448..18552 | + | 105 | Protein_27 | hypothetical protein | - |
| CW753_RS26375 (CW753_26545) | 18686..19609 | - | 924 | WP_020277922.1 | cation diffusion facilitator family transporter | - |
| CW753_RS26380 (CW753_26550) | 19809..20381 | - | 573 | WP_001515348.1 | cytochrome b/b6 domain-containing protein | - |
| CW753_RS26385 (CW753_26555) | 20857..21975 | - | 1119 | Protein_30 | IS110 family transposase | - |
| CW753_RS26390 (CW753_26560) | 22036..23004 | - | 969 | WP_077257689.1 | IS5-like element IS903B family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..145759 | 145759 | |
| - | inside | IScluster/Tn | - | - | 16796..23004 | 6208 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T89890 WP_000323025.1 NZ_CP025212:c18184-17897 [Klebsiella pneumoniae]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T89890 NZ_CP025212:c18184-17897 [Klebsiella pneumoniae]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT89890 WP_000534858.1 NZ_CP025212:c18423-18184 [Klebsiella pneumoniae]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT89890 NZ_CP025212:c18423-18184 [Klebsiella pneumoniae]
ATGGGTAGCATTAACCTACGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGACTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTACGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGACTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|