Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3669043..3669559 Replicon chromosome
Accession NZ_CP025211
Organism Klebsiella pneumoniae strain HZW25

Toxin (Protein)


Gene name relE Uniprot ID A0A085DK79
Locus tag CW753_RS18455 Protein ID WP_009309309.1
Coordinates 3669043..3669327 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag CW753_RS18460 Protein ID WP_002886901.1
Coordinates 3669317..3669559 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CW753_RS18435 (CW753_18490) 3664519..3664782 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
CW753_RS29390 3664912..3665085 + 174 WP_032408826.1 hypothetical protein -
CW753_RS18440 (CW753_18495) 3665088..3665831 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
CW753_RS18445 (CW753_18500) 3666188..3668326 + 2139 WP_004222153.1 anaerobic ribonucleoside-triphosphate reductase -
CW753_RS18450 (CW753_18505) 3668575..3669039 + 465 WP_134082642.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
CW753_RS18455 (CW753_18510) 3669043..3669327 - 285 WP_009309309.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CW753_RS18460 (CW753_18515) 3669317..3669559 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
CW753_RS18465 (CW753_18520) 3669637..3671547 - 1911 WP_004152270.1 PRD domain-containing protein -
CW753_RS18470 (CW753_18525) 3671570..3672724 - 1155 WP_004178372.1 lactonase family protein -
CW753_RS18475 (CW753_18530) 3672791..3673531 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11141.99 Da        Isoelectric Point: 10.3787

>T89883 WP_009309309.1 NZ_CP025211:c3669327-3669043 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T89883 NZ_CP025211:c3669327-3669043 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCTGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT89883 WP_002886901.1 NZ_CP025211:c3669559-3669317 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT89883 NZ_CP025211:c3669559-3669317 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A085DK79

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References