Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PanAT/Fic-DUF4065 |
| Location | 714588..715618 | Replicon | chromosome |
| Accession | NZ_CP025209 | ||
| Organism | Corynebacterium diphtheriae bv. mitis str. ISS 3319 | ||
Toxin (Protein)
| Gene name | panT | Uniprot ID | - |
| Locus tag | AL06_RS03660 | Protein ID | WP_014303124.1 |
| Coordinates | 714588..715040 (-) | Length | 151 a.a. |
Antitoxin (Protein)
| Gene name | panA | Uniprot ID | A0A806GUF5 |
| Locus tag | AL06_RS03665 | Protein ID | WP_014318824.1 |
| Coordinates | 715052..715618 (-) | Length | 189 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AL06_RS03635 | 711245..712099 | + | 855 | WP_014303121.1 | hypothetical protein | - |
| AL06_RS03640 | 712092..713000 | - | 909 | WP_014309246.1 | DUF1906 domain-containing protein | - |
| AL06_RS03645 | 713129..714328 | - | 1200 | WP_014318823.1 | cation:proton antiporter | - |
| AL06_RS03660 | 714588..715040 | - | 453 | WP_014303124.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
| AL06_RS03665 | 715052..715618 | - | 567 | WP_014318824.1 | SocA family protein | Antitoxin |
| AL06_RS11840 | 715951..716226 | + | 276 | WP_014309249.1 | hypothetical protein | - |
| AL06_RS03680 | 716898..717173 | + | 276 | WP_014301596.1 | hypothetical protein | - |
| AL06_RS03685 | 717180..717932 | + | 753 | WP_014318826.1 | precorrin-6A synthase (deacetylating) | - |
| AL06_RS03690 | 717951..718208 | - | 258 | WP_010934589.1 | mycoredoxin | - |
| AL06_RS03695 | 718229..718732 | - | 504 | WP_014303129.1 | dihydrofolate reductase | - |
| AL06_RS03700 | 718732..719544 | - | 813 | WP_014318827.1 | thymidylate synthase | - |
| AL06_RS03705 | 719638..720396 | - | 759 | WP_014318828.1 | 3'(2'),5'-bisphosphate nucleotidase CysQ | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 714588..725249 | 10661 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 151 a.a. Molecular weight: 16477.60 Da Isoelectric Point: 7.7987
>T89869 WP_014303124.1 NZ_CP025209:c715040-714588 [Corynebacterium diphtheriae bv. mitis str. ISS 3319]
VSGNSGASPQDMVNKLVYLSCTLNQECGKRTGPHREPEPFLGFSVRDRSGLEGAIASVFQSSFGVLLYPTIYDQAAALLF
KLANGHYFQDGNKRTAFHLCLAYLRANNVHVSPPRSDDVITLLQTTVSRSGSQENGIAFVRQKLLDWTVD
VSGNSGASPQDMVNKLVYLSCTLNQECGKRTGPHREPEPFLGFSVRDRSGLEGAIASVFQSSFGVLLYPTIYDQAAALLF
KLANGHYFQDGNKRTAFHLCLAYLRANNVHVSPPRSDDVITLLQTTVSRSGSQENGIAFVRQKLLDWTVD
Download Length: 453 bp
>T89869 NZ_CP025209:c715040-714588 [Corynebacterium diphtheriae bv. mitis str. ISS 3319]
GTGTCGGGAAATAGCGGGGCGTCACCGCAGGACATGGTGAACAAGTTGGTCTACTTATCCTGCACCTTAAATCAGGAGTG
CGGGAAGCGAACAGGTCCTCACAGAGAACCTGAACCTTTTCTTGGATTCTCCGTGAGGGATCGGAGTGGGCTAGAGGGCG
CGATCGCTTCAGTATTTCAATCGTCGTTTGGCGTCTTGCTGTACCCGACCATCTACGACCAAGCGGCCGCACTCCTGTTC
AAGCTGGCAAACGGGCATTACTTCCAAGACGGAAACAAGCGAACAGCATTCCACCTGTGCTTAGCCTACCTACGGGCCAA
TAACGTTCACGTCAGTCCCCCTCGGTCTGATGACGTCATCACTTTACTTCAGACCACGGTGAGTCGCTCAGGAAGCCAAG
AAAACGGGATAGCGTTCGTTAGACAAAAGCTTTTGGACTGGACCGTAGACTGA
GTGTCGGGAAATAGCGGGGCGTCACCGCAGGACATGGTGAACAAGTTGGTCTACTTATCCTGCACCTTAAATCAGGAGTG
CGGGAAGCGAACAGGTCCTCACAGAGAACCTGAACCTTTTCTTGGATTCTCCGTGAGGGATCGGAGTGGGCTAGAGGGCG
CGATCGCTTCAGTATTTCAATCGTCGTTTGGCGTCTTGCTGTACCCGACCATCTACGACCAAGCGGCCGCACTCCTGTTC
AAGCTGGCAAACGGGCATTACTTCCAAGACGGAAACAAGCGAACAGCATTCCACCTGTGCTTAGCCTACCTACGGGCCAA
TAACGTTCACGTCAGTCCCCCTCGGTCTGATGACGTCATCACTTTACTTCAGACCACGGTGAGTCGCTCAGGAAGCCAAG
AAAACGGGATAGCGTTCGTTAGACAAAAGCTTTTGGACTGGACCGTAGACTGA
Antitoxin
Download Length: 189 a.a. Molecular weight: 21053.55 Da Isoelectric Point: 4.5592
>AT89869 WP_014318824.1 NZ_CP025209:c715618-715052 [Corynebacterium diphtheriae bv. mitis str. ISS 3319]
MISIHDVAARVLELHPSCDKMKLYKLCYFSQGWHLAWTGRPLFNEELQAWKYGAVSPTLRQASELRADDDRRVTQIWSGD
SSQLTDYERSVVDTVVSFYGDLGSFHLSDLSHGFAWSTVRGDLPPDASCSDVIPHSLIRREFVENAWGEAPTPNAPERLP
SMALDSLEQAADDVAAENAETLRLLAFI
MISIHDVAARVLELHPSCDKMKLYKLCYFSQGWHLAWTGRPLFNEELQAWKYGAVSPTLRQASELRADDDRRVTQIWSGD
SSQLTDYERSVVDTVVSFYGDLGSFHLSDLSHGFAWSTVRGDLPPDASCSDVIPHSLIRREFVENAWGEAPTPNAPERLP
SMALDSLEQAADDVAAENAETLRLLAFI
Download Length: 567 bp
>AT89869 NZ_CP025209:c715618-715052 [Corynebacterium diphtheriae bv. mitis str. ISS 3319]
ATGATCAGCATCCACGATGTTGCAGCGCGTGTACTTGAGCTGCACCCTTCCTGCGACAAGATGAAGCTGTACAAACTGTG
TTACTTCTCCCAGGGGTGGCACTTGGCATGGACAGGTCGTCCACTATTCAACGAAGAGCTACAGGCGTGGAAGTACGGGG
CCGTATCTCCTACTTTGCGTCAGGCTAGCGAGCTTCGTGCCGATGATGACCGTCGAGTGACCCAAATTTGGAGCGGGGAC
AGTTCTCAACTCACCGATTACGAGCGGTCAGTCGTGGACACTGTTGTTTCGTTCTATGGAGATCTTGGGTCTTTTCACCT
GTCCGATTTAAGCCACGGCTTCGCCTGGTCCACCGTACGAGGCGACCTTCCTCCAGACGCCTCGTGCAGCGATGTGATCC
CTCACTCTCTGATCCGTCGTGAGTTTGTCGAGAATGCTTGGGGCGAAGCTCCTACGCCAAACGCTCCTGAACGCCTGCCT
TCCATGGCACTTGATTCTCTCGAGCAGGCAGCCGATGACGTTGCTGCCGAAAATGCAGAGACGCTTCGACTTCTCGCTTT
CATCTAG
ATGATCAGCATCCACGATGTTGCAGCGCGTGTACTTGAGCTGCACCCTTCCTGCGACAAGATGAAGCTGTACAAACTGTG
TTACTTCTCCCAGGGGTGGCACTTGGCATGGACAGGTCGTCCACTATTCAACGAAGAGCTACAGGCGTGGAAGTACGGGG
CCGTATCTCCTACTTTGCGTCAGGCTAGCGAGCTTCGTGCCGATGATGACCGTCGAGTGACCCAAATTTGGAGCGGGGAC
AGTTCTCAACTCACCGATTACGAGCGGTCAGTCGTGGACACTGTTGTTTCGTTCTATGGAGATCTTGGGTCTTTTCACCT
GTCCGATTTAAGCCACGGCTTCGCCTGGTCCACCGTACGAGGCGACCTTCCTCCAGACGCCTCGTGCAGCGATGTGATCC
CTCACTCTCTGATCCGTCGTGAGTTTGTCGAGAATGCTTGGGGCGAAGCTCCTACGCCAAACGCTCCTGAACGCCTGCCT
TCCATGGCACTTGATTCTCTCGAGCAGGCAGCCGATGACGTTGCTGCCGAAAATGCAGAGACGCTTCGACTTCTCGCTTT
CATCTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|