Detailed information of TA system TA089868

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-pasA/RelE-HTH
• Location: 101195..101678
• Replicon: chromosome
• Accession: NZ_CP025209
• Organism: Corynebacterium diphtheriae bv. mitis str. ISS 3319

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A806GHY4
• Locus tag: AL06_RS00570
• Protein ID: WP_014302726.1
• Coordinates: 101415..101678 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: -
• Locus tag: AL06_RS00565
• Protein ID: WP_003850117.1
• Coordinates: 101195..101431 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AL06_RS00535	96574..97129	+	556	Protein_95	LysE family transporter	-
AL06_RS00545	97238..97996	+	759	WP_003850109.1	hypothetical protein	-
AL06_RS00550	98276..99798	+	1523	Protein_97	IS30 family transposase	-
AL06_RS00555	100009..100692	-	684	WP_014302723.1	hypothetical protein	-
AL06_RS00565	101195..101431	+	237	WP_003850117.1	ribbon-helix-helix domain-containing protein	Antitoxin
AL06_RS00570	101415..101678	+	264	WP_014302726.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AL06_RS00575	101805..102098	+	294	WP_014302727.1	RNA-binding S4 domain-containing protein	-
AL06_RS00580	102098..102922	+	825	WP_014301205.1	VOC family protein	-
AL06_RS00585	102928..103233	+	306	WP_003850125.1	MGMT family protein	-
AL06_RS00590	103243..104163	-	921	WP_003850127.1	alpha/beta hydrolase	-
AL06_RS00595	104303..104929	+	627	WP_014318472.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	67228..102098	34870

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-86)

Antitoxin

• Predicted DNA-binding protein, ribbon-helix-helix domain (7-43)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 9911.45 Da
• Isoelectric Point: 10.9201

>T89868 WP_014302726.1 NZ_CP025209:101415-101678 [Corynebacterium diphtheriae bv. mitis str. ISS 3319]
VAWEISFSPRAVKSFKKLDTGEQRRVSKFLREVGALEDPRLRGKALTANKSGLWRWRVGDYRIIADIVDARVVVVVVDVG
HRSKAYD

Nucleotide

• Length: 264 bp

>T89868 NZ_CP025209:101415-101678 [Corynebacterium diphtheriae bv. mitis str. ISS 3319]
GTGGCTTGGGAGATTAGTTTTTCTCCTCGGGCGGTGAAGTCGTTTAAGAAGCTCGATACGGGTGAGCAGCGGAGGGTGAG
TAAGTTTCTGCGGGAGGTTGGCGCCCTTGAGGACCCGAGGTTACGAGGTAAGGCATTAACAGCCAATAAGTCGGGTTTGT
GGCGCTGGCGTGTGGGGGACTATCGGATTATTGCTGACATTGTGGACGCGCGTGTTGTCGTCGTTGTGGTTGACGTTGGG
CACCGCTCGAAGGCCTACGACTAA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8911.02 Da
• Isoelectric Point: 4.8604

>AT89868 WP_003850117.1 NZ_CP025209:101195-101431 [Corynebacterium diphtheriae bv. mitis str. ISS 3319]
MSGSVISLRIDDEQKRRLDELSRRTGRPCSFYLREALSAHLADLEYVYRLEEEAAQVRRGELGTVPLSQLERECGLGD

Nucleotide

• Length: 237 bp

>AT89868 NZ_CP025209:101195-101431 [Corynebacterium diphtheriae bv. mitis str. ISS 3319]
ATGAGTGGTTCGGTGATTAGCTTGCGTATCGATGACGAGCAGAAGCGGCGTTTGGATGAGCTGTCGCGACGTACGGGGCG
GCCGTGTTCGTTTTATCTTCGGGAAGCGTTGAGTGCACATCTGGCTGATCTGGAGTATGTGTATCGCTTGGAGGAGGAGG
CTGCTCAGGTTCGTCGCGGGGAGTTGGGAACTGTGCCGTTGAGTCAGCTGGAGCGCGAGTGTGGCTTGGGAGATTAG

Structures

Toxin

• AlphaFold DB: A0A806GHY4