Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 3303023..3303617 Replicon chromosome
Accession NZ_CP025198
Organism Acidipropionibacterium virtanenii strain JS278

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag JS278_RS15160 Protein ID WP_114046380.1
Coordinates 3303023..3303325 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag JS278_RS15165 Protein ID WP_114045919.1
Coordinates 3303318..3303617 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JS278_RS15155 3301515..3302831 - 1317 WP_181833764.1 NarK/NasA family nitrate transporter -
JS278_RS15160 3303023..3303325 + 303 WP_114046380.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JS278_RS15165 3303318..3303617 + 300 WP_114045919.1 putative addiction module antidote protein Antitoxin
JS278_RS15170 3303841..3305052 + 1212 WP_114045920.1 cytochrome P450 -
JS278_RS15175 3305052..3305681 + 630 WP_114045921.1 flavin reductase family protein -
JS278_RS15180 3305775..3306002 - 228 WP_114045922.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
JS278_RS15185 3306201..3306839 + 639 WP_114045923.1 NTP transferase domain-containing protein -
JS278_RS15190 3306866..3307183 - 318 WP_114045924.1 type II toxin-antitoxin system PemK/MazF family toxin -
JS278_RS15195 3307173..3307403 - 231 WP_114045925.1 ribbon-helix-helix protein, CopG family -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(52-93)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11244.85 Da        Isoelectric Point: 10.4277

>T89867 WP_114046380.1 NZ_CP025198:3303023-3303325 [Acidipropionibacterium virtanenii]
IVQVIKSTTFDQWLRKLKDHAAVGRILARIDRLTSGNPGDVRPVGGGVSELRIPYGPGYRVYYLQRGSRIILLLCGGDKS
SQARDIETAHRIAQEWRNNE

Download         Length: 303 bp

>T89867 NZ_CP025198:3303023-3303325 [Acidipropionibacterium virtanenii]
ATCGTCCAGGTCATCAAGAGCACGACATTCGACCAGTGGCTGCGAAAGCTCAAGGACCACGCAGCCGTTGGCCGGATCCT
CGCGCGGATTGATCGGCTCACCTCGGGCAATCCGGGCGACGTCAGGCCGGTCGGAGGCGGTGTCTCAGAGCTGCGTATCC
CCTATGGTCCCGGATATCGCGTCTACTACCTGCAGCGCGGCTCCCGGATCATCCTGCTGCTCTGCGGTGGCGACAAGTCG
AGCCAGGCACGAGACATAGAGACGGCACACCGCATCGCCCAGGAGTGGAGGAACAATGAGTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10538.77 Da        Isoelectric Point: 4.4091

>AT89867 WP_114045919.1 NZ_CP025198:3303318-3303617 [Acidipropionibacterium virtanenii]
MSENAEQFSAFDTADYLENLDDAAAYLEATLADSDDPALIARALGTIARSGNLSQLARRIGMSREGLYKALSADGNPSFA
TITKVAGALGLRLRFEPAR

Download         Length: 300 bp

>AT89867 NZ_CP025198:3303318-3303617 [Acidipropionibacterium virtanenii]
ATGAGTGAGAACGCAGAGCAGTTCAGTGCCTTCGACACTGCGGACTACCTGGAGAACCTTGACGACGCCGCCGCCTATCT
CGAAGCCACCCTGGCGGACAGCGATGACCCCGCACTCATCGCCCGTGCACTGGGCACGATTGCCAGATCCGGCAACCTCA
GCCAGCTCGCCCGCCGGATCGGCATGAGCCGGGAAGGGCTCTACAAGGCCCTTTCCGCCGACGGCAATCCCAGCTTCGCC
ACCATCACGAAAGTTGCCGGCGCGCTCGGGCTGAGACTCCGCTTCGAGCCCGCCCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References