Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2119191..2119744 Replicon chromosome
Accession NZ_CP025198
Organism Acidipropionibacterium virtanenii strain JS278

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag JS278_RS09780 Protein ID WP_114045006.1
Coordinates 2119430..2119744 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag JS278_RS09775 Protein ID WP_114045005.1
Coordinates 2119191..2119433 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JS278_RS09750 2114437..2115648 + 1212 WP_181833900.1 chorismate-binding protein -
JS278_RS09755 2115781..2117373 - 1593 WP_114045002.1 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylic-acid synthase -
JS278_RS09760 2117366..2118364 - 999 WP_114045003.1 o-succinylbenzoate synthase -
JS278_RS09765 2118440..2119024 + 585 WP_114045004.1 DinB family protein -
JS278_RS09775 2119191..2119433 + 243 WP_114045005.1 hypothetical protein Antitoxin
JS278_RS09780 2119430..2119744 + 315 WP_114045006.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
JS278_RS09785 2119768..2121621 - 1854 WP_114045007.1 translation elongation factor 4 -
JS278_RS09790 2121785..2122051 + 267 WP_114045008.1 30S ribosomal protein S20 -
JS278_RS09795 2122152..2123216 - 1065 WP_114045009.1 DNA polymerase III subunit delta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-98)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11159.98 Da        Isoelectric Point: 7.1339

>T89861 WP_114045006.1 NZ_CP025198:2119430-2119744 [Acidipropionibacterium virtanenii]
MRPIHLARIEKTRPVLVLTRDLARPAMSKVTVAPITSTVKGLSTEVPVGPANGLDHDCVVSCDNIATISTTNLGRQIGWF
TDQQERALAAALVVAFDLDLPLIS

Download         Length: 315 bp

>T89861 NZ_CP025198:2119430-2119744 [Acidipropionibacterium virtanenii]
ATGAGGCCGATCCATCTCGCCCGCATCGAGAAGACACGCCCGGTCCTCGTCCTCACCCGGGACCTCGCGCGCCCGGCCAT
GTCGAAGGTGACCGTGGCACCCATCACATCGACTGTCAAAGGACTGTCGACCGAGGTGCCGGTGGGTCCGGCGAACGGCC
TGGACCACGACTGCGTCGTGAGCTGTGACAACATCGCCACGATCTCCACGACGAATCTTGGCCGCCAGATCGGATGGTTC
ACCGATCAGCAGGAAAGGGCGCTGGCCGCGGCGCTCGTCGTCGCCTTCGACCTGGACCTCCCTCTCATCAGCTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8841.63 Da        Isoelectric Point: 4.1228

>AT89861 WP_114045005.1 NZ_CP025198:2119191-2119433 [Acidipropionibacterium virtanenii]
MTTQIAVRLPDDVVSWVDSQVSGGAAPSRAAVVSHALEREFRRAAAERDAQILRENPNDDLDGFVSWTAEHFTMDEDPES

Download         Length: 243 bp

>AT89861 NZ_CP025198:2119191-2119433 [Acidipropionibacterium virtanenii]
ATGACTACTCAGATCGCGGTCCGCCTTCCCGACGACGTCGTCTCATGGGTCGATTCCCAGGTGAGCGGCGGCGCGGCGCC
CAGTCGTGCCGCCGTCGTCTCCCACGCCCTCGAACGAGAGTTTCGCCGCGCCGCGGCCGAACGCGATGCACAGATCCTCC
GGGAGAATCCGAACGACGACCTGGACGGTTTCGTGTCCTGGACTGCGGAGCATTTCACCATGGACGAGGATCCGGAGTCA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References