Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-PHD
Location 1392534..1393177 Replicon chromosome
Accession NZ_CP025198
Organism Acidipropionibacterium virtanenii strain JS278

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JS278_RS06420 Protein ID WP_114044452.1
Coordinates 1392534..1392944 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag JS278_RS06425 Protein ID WP_114046166.1
Coordinates 1392941..1393177 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JS278_RS06380 1387994..1389310 + 1317 WP_114044444.1 hypothetical protein -
JS278_RS06385 1389339..1389596 + 258 WP_114044445.1 hypothetical protein -
JS278_RS06390 1389602..1389862 + 261 WP_147243164.1 hypothetical protein -
JS278_RS06395 1389869..1390156 + 288 WP_114044447.1 hypothetical protein -
JS278_RS06400 1390153..1390428 + 276 WP_114044448.1 hypothetical protein -
JS278_RS06405 1390454..1390747 - 294 WP_147243165.1 helix-turn-helix domain-containing protein -
JS278_RS06410 1390827..1391429 - 603 WP_114044450.1 peptide deformylase -
JS278_RS06415 1391467..1392504 - 1038 WP_114044451.1 beta-propeller fold lactonase family protein -
JS278_RS06420 1392534..1392944 - 411 WP_114044452.1 type II toxin-antitoxin system VapC family toxin Toxin
JS278_RS06425 1392941..1393177 - 237 WP_114046166.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
JS278_RS06430 1393269..1394198 + 930 WP_114044453.1 tyrosine recombinase XerC -
JS278_RS06435 1394218..1395225 - 1008 WP_114044454.1 M23 family metallopeptidase -
JS278_RS06440 1395329..1397293 - 1965 WP_114044455.1 SWIM zinc finger family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(26-117)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-41)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14044.68 Da        Isoelectric Point: 4.0306

>T89860 WP_114044452.1 NZ_CP025198:c1392944-1392534 [Acidipropionibacterium virtanenii]
VSRERGVLDTSTVIRLGEVTDASQLPDDSVITAVTLAELAVGPLVATDDEDRAARQAHLQQAEADFDVLPFDAAAARAFG
GVATSLRAAGRKPTARAYDALIAATAIANGLPVFTCNPADFEGINGLDVEPVLIGD

Download         Length: 411 bp

>T89860 NZ_CP025198:c1392944-1392534 [Acidipropionibacterium virtanenii]
GTGAGCAGGGAGCGTGGCGTCCTCGACACGTCTACGGTCATCCGCCTGGGTGAAGTGACGGACGCGTCCCAACTGCCTGA
CGATTCAGTCATCACGGCGGTGACACTCGCCGAGCTCGCTGTCGGACCGCTCGTGGCGACCGATGACGAGGACCGAGCGG
CTCGGCAGGCGCATCTGCAACAGGCGGAGGCTGATTTCGACGTCCTCCCGTTCGATGCCGCGGCGGCTCGTGCGTTCGGC
GGTGTCGCCACCAGTCTGCGAGCGGCAGGGCGCAAGCCCACGGCTCGCGCGTACGACGCCCTCATCGCTGCGACGGCGAT
CGCGAACGGCCTACCGGTCTTCACCTGCAACCCGGCCGATTTTGAAGGCATCAACGGACTGGACGTCGAGCCGGTACTGA
TCGGGGATTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8584.87 Da        Isoelectric Point: 11.8979

>AT89860 WP_114046166.1 NZ_CP025198:c1393177-1392941 [Acidipropionibacterium virtanenii]
MDTVTVRDLRNHGGEVLDRVGRGESIIVTRNGAPAARLTPLRRRSAPPAELIERRRRLAPVDPGALRRDIDAVLDPAL

Download         Length: 237 bp

>AT89860 NZ_CP025198:c1393177-1392941 [Acidipropionibacterium virtanenii]
ATGGACACAGTGACGGTTCGGGACTTGAGGAACCATGGCGGCGAGGTGCTCGATCGCGTCGGCCGTGGCGAATCCATCAT
CGTGACCCGCAATGGCGCTCCCGCGGCCCGGTTGACTCCGCTGCGTCGACGCAGCGCTCCCCCGGCCGAACTCATCGAAC
GGCGCCGCCGGTTGGCCCCGGTCGATCCCGGAGCACTGCGCCGTGACATCGACGCCGTACTGGATCCGGCACTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References