Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 860190..860830 Replicon chromosome
Accession NZ_CP025198
Organism Acidipropionibacterium virtanenii strain JS278

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JS278_RS03815 Protein ID WP_114044038.1
Coordinates 860190..860582 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag JS278_RS03820 Protein ID WP_114044039.1
Coordinates 860579..860830 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JS278_RS03785 855400..855795 + 396 Protein_748 CoA-disulfide reductase -
JS278_RS03790 855931..856194 - 264 WP_114046100.1 metal-sensitive transcriptional regulator -
JS278_RS03795 856373..857047 + 675 WP_114044034.1 DUF3151 family protein -
JS278_RS03800 857121..857999 + 879 WP_114044035.1 GNAT family N-acetyltransferase -
JS278_RS03805 858135..859421 + 1287 WP_114044036.1 adenylosuccinate synthase -
JS278_RS03810 859459..860196 + 738 WP_114044037.1 phosphotransferase -
JS278_RS03815 860190..860582 - 393 WP_114044038.1 type II toxin-antitoxin system VapC family toxin Toxin
JS278_RS03820 860579..860830 - 252 WP_114044039.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JS278_RS03825 861068..862384 + 1317 WP_114046101.1 phosphoribosylamine--glycine ligase -
JS278_RS03830 862430..863863 + 1434 WP_114044040.1 adenylosuccinate lyase -
JS278_RS03835 863888..865222 + 1335 WP_114044041.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-82)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 13512.17 Da        Isoelectric Point: 3.8401

>T89859 WP_114044038.1 NZ_CP025198:c860582-860190 [Acidipropionibacterium virtanenii]
MIVDSSVLVAVLTGEPDAEHYLDLMIGADHLVVSAAGLVESSVVLEARAGAEAVTDLQALLADLEADVLPLDEDQAILAS
QAWSRFGKGRHLAGLNLGDLFAYAAASGLGEPLLFKGDDFAQTDIPSADH

Download         Length: 393 bp

>T89859 NZ_CP025198:c860582-860190 [Acidipropionibacterium virtanenii]
ATGATCGTCGACAGCTCGGTGCTGGTCGCGGTGCTCACCGGCGAGCCCGATGCGGAGCACTATCTGGACCTCATGATCGG
CGCCGATCACCTCGTGGTGAGCGCCGCCGGCCTGGTCGAGAGCTCGGTCGTCCTCGAGGCCCGGGCCGGGGCGGAGGCTG
TCACCGATCTCCAGGCACTCCTCGCCGATCTGGAGGCCGACGTCCTCCCTCTCGACGAGGACCAGGCGATCCTGGCGTCA
CAGGCATGGAGCAGGTTCGGGAAGGGACGCCACCTCGCGGGCCTGAACCTGGGTGACCTCTTCGCCTACGCCGCGGCGTC
CGGTCTGGGCGAGCCGCTCCTGTTCAAGGGGGACGACTTCGCCCAGACCGACATCCCGTCGGCCGATCACTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9377.49 Da        Isoelectric Point: 7.3200

>AT89859 WP_114044039.1 NZ_CP025198:c860830-860579 [Acidipropionibacterium virtanenii]
MALNIKDADTDRLARELAAETGETITTALRTAVAERLARVRRQHHVSARPDLHRYIDRARARTVLDGRDADEILGYDENG
LPR

Download         Length: 252 bp

>AT89859 NZ_CP025198:c860830-860579 [Acidipropionibacterium virtanenii]
ATGGCTCTCAACATCAAGGATGCCGATACCGATCGGCTGGCCCGCGAACTGGCCGCCGAGACCGGCGAGACCATCACGAC
CGCACTGCGCACAGCGGTGGCCGAGCGTCTGGCGCGGGTCCGACGGCAGCATCACGTGTCGGCGCGTCCGGACCTGCATC
GCTATATCGACCGGGCCCGGGCAAGGACCGTACTCGACGGACGGGACGCCGACGAGATCCTCGGCTATGACGAGAACGGA
CTGCCCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References