Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 235668..236232 Replicon chromosome
Accession NZ_CP025198
Organism Acidipropionibacterium virtanenii strain JS278

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag JS278_RS01055 Protein ID WP_114043568.1
Coordinates 235885..236232 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag JS278_RS01050 Protein ID WP_114043567.1
Coordinates 235668..235898 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JS278_RS01035 232710..234842 - 2133 WP_114043564.1 NAD(+) synthase -
JS278_RS01040 234858..235286 - 429 WP_114043565.1 type II toxin-antitoxin system VapC family toxin -
JS278_RS01045 235283..235522 - 240 WP_114043566.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
JS278_RS01050 235668..235898 + 231 WP_114043567.1 ribbon-helix-helix domain-containing protein Antitoxin
JS278_RS01055 235885..236232 + 348 WP_114043568.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
JS278_RS01060 236337..237269 - 933 WP_114043569.1 carbohydrate kinase -
JS278_RS01065 237526..239061 + 1536 WP_114043570.1 glycoside hydrolase family 32 protein -
JS278_RS01070 239576..239953 + 378 WP_114046038.1 L,D-transpeptidase -
JS278_RS01075 240139..241044 + 906 WP_114043571.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-112)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-35)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12510.51 Da        Isoelectric Point: 11.4911

>T89857 WP_114043568.1 NZ_CP025198:235885-236232 [Acidipropionibacterium virtanenii]
MIRGEIRLVDLDPARPAEVNKRRPAVIVSNDAANRTAGRLGRGVVTVVPVTSNINRIFPFQVLLPADGTGLRRDSKAQAE
QVRSVSVERIGPVLGVVPADLMTRVDDALRLHLEL

Download         Length: 348 bp

>T89857 NZ_CP025198:235885-236232 [Acidipropionibacterium virtanenii]
ATGATCCGCGGTGAGATCAGGCTGGTCGACCTGGATCCGGCACGCCCCGCGGAGGTGAACAAGCGGCGACCGGCCGTCAT
CGTCAGCAACGACGCGGCGAACCGGACGGCCGGACGACTGGGGCGAGGGGTGGTGACGGTGGTACCGGTCACCAGCAACA
TCAACCGGATCTTCCCGTTCCAGGTGTTGCTGCCAGCCGATGGGACAGGCCTGCGGCGCGATTCCAAGGCACAGGCCGAG
CAGGTCCGCTCGGTGTCGGTCGAGCGGATCGGCCCGGTGCTGGGCGTGGTTCCGGCAGACCTCATGACCAGAGTCGATGA
CGCCCTGAGGCTCCACCTGGAGCTATAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8222.09 Da        Isoelectric Point: 4.1546

>AT89857 WP_114043567.1 NZ_CP025198:235668-235898 [Acidipropionibacterium virtanenii]
MKLSVSLSKEQVETIDRYIRATGMRSRSAVIQKAIGMLETTGLGDDYAAAWTEWEASGDAEAWESAAADGLADDPR

Download         Length: 231 bp

>AT89857 NZ_CP025198:235668-235898 [Acidipropionibacterium virtanenii]
ATGAAGCTGAGTGTGAGCCTGTCGAAGGAGCAGGTGGAGACCATCGACCGGTACATCCGCGCCACCGGGATGAGGTCGAG
GTCCGCGGTGATCCAGAAGGCCATCGGCATGCTCGAGACGACCGGGCTGGGAGACGACTACGCCGCCGCCTGGACGGAGT
GGGAGGCGTCGGGAGACGCCGAGGCATGGGAGTCCGCAGCGGCCGATGGTCTCGCCGATGATCCGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References