Detailed information of TA system TA089856

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/AbrB(antitoxin)
• Location: 234858..235522
• Replicon: chromosome
• Accession: NZ_CP025198
• Organism: Acidipropionibacterium virtanenii strain JS278

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: JS278_RS01040
• Protein ID: WP_114043565.1
• Coordinates: 234858..235286 (-)
• Length: 143 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: JS278_RS01045
• Protein ID: WP_114043566.1
• Coordinates: 235283..235522 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JS278_RS01035	232710..234842	-	2133	WP_114043564.1	NAD(+) synthase	-
JS278_RS01040	234858..235286	-	429	WP_114043565.1	type II toxin-antitoxin system VapC family toxin	Toxin
JS278_RS01045	235283..235522	-	240	WP_114043566.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
JS278_RS01050	235668..235898	+	231	WP_114043567.1	ribbon-helix-helix domain-containing protein	-
JS278_RS01055	235885..236232	+	348	WP_114043568.1	type II toxin-antitoxin system PemK/MazF family toxin	-
JS278_RS01060	236337..237269	-	933	WP_114043569.1	carbohydrate kinase	-
JS278_RS01065	237526..239061	+	1536	WP_114043570.1	glycoside hydrolase family 32 protein	-
JS278_RS01070	239576..239953	+	378	WP_114046038.1	L,D-transpeptidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (9-126)

Antitoxin

• SpoVT-AbrB domain (5-42)

Sequences

Toxin

Protein

• Length: 143 a.a.
• Molecular weight: 15032.93 Da
• Isoelectric Point: 6.3292

>T89856 WP_114043565.1 NZ_CP025198:c235286-234858 [Acidipropionibacterium virtanenii]
MTPSPRLAVDTSVAIPLLVRSHVQHRAVAEWASGRTLTLSGHALAETYSVLTRLPGDARVSPQDAVTLIEENFTEPLILS
ASAARHAPRELASSGVAGGATYDGLVALASREHDAVLVTRDSRARSTYQALDVPVRVLADEA

Nucleotide

• Length: 429 bp

>T89856 NZ_CP025198:c235286-234858 [Acidipropionibacterium virtanenii]
ATGACCCCTTCGCCCCGACTGGCTGTGGACACCAGTGTCGCCATCCCCCTCCTCGTAAGATCTCACGTGCAGCACCGCGC
CGTCGCCGAATGGGCCTCAGGCAGAACCTTGACCCTGAGTGGGCACGCACTTGCGGAGACGTACTCGGTCCTCACCCGCT
TGCCCGGGGATGCGCGCGTCTCCCCGCAGGATGCGGTGACGTTGATCGAGGAGAACTTCACAGAGCCGTTGATCCTCTCT
GCGTCCGCCGCCCGCCACGCGCCCCGAGAACTCGCGTCCTCAGGCGTCGCCGGGGGAGCAACATATGACGGGCTGGTCGC
CCTGGCTTCACGTGAGCACGATGCTGTCCTCGTGACGCGCGACTCCCGGGCGAGGTCGACCTACCAGGCCCTTGACGTTC
CGGTGAGGGTTCTCGCGGACGAAGCGTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8390.50 Da
• Isoelectric Point: 5.0022

>AT89856 WP_114043566.1 NZ_CP025198:c235522-235283 [Acidipropionibacterium virtanenii]
METIIDSGGRVVLPKPLRDALGLTPGTTVDISAYGAGLQLIPGGRTARLEREDNGRLVSHGQTEVTDEAMYALIDAGRR

Nucleotide

• Length: 240 bp

>AT89856 NZ_CP025198:c235522-235283 [Acidipropionibacterium virtanenii]
ATGGAGACGATCATCGATTCGGGAGGACGCGTCGTGCTTCCCAAGCCTTTACGCGACGCCCTGGGACTGACACCCGGGAC
GACGGTGGACATCTCGGCTTACGGCGCAGGCCTCCAACTGATCCCCGGCGGTCGGACAGCACGGCTCGAACGAGAGGACA
ATGGCCGACTCGTCTCCCATGGCCAGACCGAGGTCACGGACGAGGCGATGTACGCGCTCATCGACGCGGGTCGGCGATGA