Detailed information of TA system TA089855

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PHD(antitoxin)
• Location: 28557..29266
• Replicon: chromosome
• Accession: NZ_CP025198
• Organism: Acidipropionibacterium virtanenii strain JS278

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: JS278_RS00135
• Protein ID: WP_114043404.1
• Coordinates: 28557..29006 (-)
• Length: 150 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: JS278_RS00140
• Protein ID: WP_114043405.1
• Coordinates: 29003..29266 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JS278_RS00090	23561..23944	+	384	WP_114043398.1	D-ribose pyranase	-
JS278_RS00095	23946..24707	-	762	WP_114043399.1	ABC transporter permease	-
JS278_RS00100	24704..25513	-	810	WP_114043400.1	ATP-binding cassette domain-containing protein	-
JS278_RS00105	25510..25947	-	438	WP_114043401.1	DUF1048 domain-containing protein	-
JS278_RS00110	25944..26273	-	330	WP_114043402.1	PadR family transcriptional regulator	-
JS278_RS00115	26441..27379	-	939	WP_114043403.1	SDR family oxidoreductase	-
JS278_RS00125	27784..28137	+	354	Protein_23	type II toxin-antitoxin system RelE/ParE family toxin	-
JS278_RS00130	28143..28448	+	306	WP_181833773.1	helix-turn-helix domain-containing protein	-
JS278_RS00135	28557..29006	-	450	WP_114043404.1	type II toxin-antitoxin system VapC family toxin	Toxin
JS278_RS00140	29003..29266	-	264	WP_114043405.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
JS278_RS00145	29536..29985	+	450	WP_114043406.1	CBS domain-containing protein	-
JS278_RS00150	30029..31321	+	1293	WP_181833858.1	ArsB/NhaD family transporter	-
JS278_RS00155	31303..32598	-	1296	WP_114043408.1	MFS transporter	-
JS278_RS00160	33001..33813	-	813	WP_114043409.1	tyrosine-protein phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-118)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-41)

Sequences

Toxin

Protein

• Length: 150 a.a.
• Molecular weight: 16288.46 Da
• Isoelectric Point: 4.8410

>T89855 WP_114043404.1 NZ_CP025198:c29006-28557 [Acidipropionibacterium virtanenii]
MMFYADTSALVKLVVIEPESEALLTWLGRRDAALATSDLARTELVRSVRRPAPEAVTQARDVLSRLLLVRADAQIFDEAA
RLMPPEVRSLDAVHLATALALGDDLEGIITYDLRMADASHSLGLETVSPEHHEAPSHTASDQETGHPKR

Nucleotide

• Length: 450 bp

>T89855 NZ_CP025198:c29006-28557 [Acidipropionibacterium virtanenii]
CTGATGTTCTACGCAGACACCTCCGCACTGGTGAAGCTCGTCGTCATCGAGCCGGAATCCGAAGCTCTGCTCACATGGCT
CGGACGCCGCGACGCCGCCCTGGCGACCAGCGACCTGGCCCGCACCGAGCTGGTGCGCTCCGTGCGCCGCCCGGCTCCGG
AGGCCGTCACGCAGGCCCGCGACGTGCTGTCACGACTGCTTCTGGTGAGGGCCGATGCCCAGATCTTCGACGAAGCCGCA
CGTCTCATGCCGCCAGAGGTTCGAAGTCTCGACGCCGTACATCTCGCCACCGCGCTGGCACTGGGCGACGATCTCGAGGG
AATCATCACCTACGACCTCCGGATGGCCGACGCCTCCCACAGCCTAGGACTGGAGACCGTCTCTCCAGAGCACCACGAAG
CCCCCAGCCATACGGCGTCTGACCAGGAGACGGGGCACCCAAAGCGGTGA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9290.55 Da
• Isoelectric Point: 10.3629

>AT89855 WP_114043405.1 NZ_CP025198:c29266-29003 [Acidipropionibacterium virtanenii]
MSEVGIRELKQNASSVVRRAAAGEEITVTDRGRPVARLSAIDHGGVRGLLAADRARPPIRALSDLPAPTIAADVSSVLQQ
MRDGERY

Nucleotide

• Length: 264 bp

>AT89855 NZ_CP025198:c29266-29003 [Acidipropionibacterium virtanenii]
ATGAGTGAGGTCGGCATCCGCGAGTTGAAGCAGAACGCCTCGAGCGTCGTCCGCCGCGCCGCCGCCGGGGAGGAGATCAC
CGTGACCGACCGTGGACGGCCGGTCGCGCGACTCTCCGCCATCGACCACGGCGGAGTGCGCGGGCTGCTCGCCGCCGACC
GTGCCCGCCCCCCGATCCGGGCTCTGAGCGACCTCCCCGCCCCAACGATCGCCGCCGACGTCTCCTCGGTCCTGCAGCAG
ATGCGCGACGGGGAGCGCTACTGA