Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 861878..862535 Replicon chromosome
Accession NZ_CP025146
Organism Klebsiella pneumoniae strain KP1766

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag CXB26_RS04510 Protein ID WP_002916310.1
Coordinates 862125..862535 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag CXB26_RS04505 Protein ID WP_002916312.1
Coordinates 861878..862144 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CXB26_RS04480 857086..858519 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
CXB26_RS04485 858638..859366 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
CXB26_RS04490 859416..859727 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
CXB26_RS04495 859891..860550 + 660 WP_004174454.1 hemolysin III family protein -
CXB26_RS04500 860649..861632 - 984 WP_023286864.1 tRNA-modifying protein YgfZ -
CXB26_RS04505 861878..862144 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
CXB26_RS04510 862125..862535 + 411 WP_002916310.1 protein YgfX Toxin
CXB26_RS04515 862542..863063 - 522 WP_002916308.1 flavodoxin FldB -
CXB26_RS04520 863164..864060 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
CXB26_RS04525 864083..864796 + 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
CXB26_RS04530 864802..866535 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T89835 WP_002916310.1 NZ_CP025146:862125-862535 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T89835 NZ_CP025146:862125-862535 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT89835 WP_002916312.1 NZ_CP025146:861878-862144 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT89835 NZ_CP025146:861878-862144 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References