Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 513392..514031 Replicon chromosome
Accession NZ_CP025135
Organism Planococcus sp. MB-3u-03

Toxin (Protein)


Gene name pemK Uniprot ID A0A1C7EC77
Locus tag CW734_RS03875 Protein ID WP_058381776.1
Coordinates 513681..514031 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A1C7DXF0
Locus tag CW734_RS03870 Protein ID WP_068460417.1
Coordinates 513392..513676 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CW734_RS03845 509085..509564 + 480 WP_101189512.1 PH domain-containing protein -
CW734_RS03850 509557..511128 + 1572 WP_101192126.1 PH domain-containing protein -
CW734_RS03855 511146..511760 - 615 WP_058381780.1 rhomboid family intramembrane serine protease -
CW734_RS03860 511829..512182 + 354 WP_101189513.1 holo-ACP synthase -
CW734_RS03865 512199..513347 + 1149 WP_101189514.1 alanine racemase -
CW734_RS03870 513392..513676 + 285 WP_068460417.1 transcriptional regulator Antitoxin
CW734_RS03875 513681..514031 + 351 WP_058381776.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
CW734_RS03880 514210..515106 + 897 WP_101189515.1 STAS domain-containing protein -
CW734_RS03885 515036..515398 + 363 WP_058381774.1 STAS domain-containing protein -
CW734_RS03890 515401..515802 + 402 WP_058381773.1 anti-sigma regulatory factor -
CW734_RS03895 515815..516816 + 1002 WP_101189516.1 PP2C family protein-serine/threonine phosphatase -
CW734_RS03900 516911..517243 + 333 WP_101189517.1 anti-sigma factor antagonist -
CW734_RS03905 517246..517716 + 471 WP_058381770.1 anti-sigma B factor RsbW -
CW734_RS03910 517694..518476 + 783 WP_058381769.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12850.94 Da        Isoelectric Point: 5.8817

>T89790 WP_058381776.1 NZ_CP025135:513681-514031 [Planococcus sp. MB-3u-03]
MIVKRGDVFFAELSPVVGSEQGGTRPVLVIQNDIGNRFSPTVIIAAITAQIQKAKLPTHVEINAKKYGFERDSVILLEQL
RTIDKSRLTDKITQLDDALMEKVDEALEISVGLVKF

Download         Length: 351 bp

>T89790 NZ_CP025135:513681-514031 [Planococcus sp. MB-3u-03]
TTGATTGTAAAACGCGGGGATGTTTTTTTCGCAGAATTATCACCGGTCGTCGGGTCTGAGCAAGGTGGGACCCGTCCGGT
CTTGGTGATACAAAACGATATCGGGAACCGATTTAGTCCGACAGTGATCATTGCGGCGATCACCGCCCAGATCCAGAAAG
CCAAATTGCCGACCCACGTGGAAATCAACGCCAAGAAATACGGCTTTGAGCGTGATTCTGTTATTTTGCTTGAACAATTG
CGGACGATTGATAAATCGCGCTTGACTGATAAGATTACACAGCTGGACGATGCGTTGATGGAAAAGGTAGATGAAGCCTT
GGAAATTAGTGTCGGACTTGTAAAATTTTAG

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10705.07 Da        Isoelectric Point: 5.5819

>AT89790 WP_068460417.1 NZ_CP025135:513392-513676 [Planococcus sp. MB-3u-03]
VYEKSKTKEVVVKLPKQFMSELTAHSGERIEENGEFIYVSTQRVTKNVYDSYHIREAMIKGYVEMSQINLSIACECSHAE
YEAEHTTVQLVSGG

Download         Length: 285 bp

>AT89790 NZ_CP025135:513392-513676 [Planococcus sp. MB-3u-03]
GTGTACGAGAAGTCAAAGACGAAAGAAGTGGTAGTCAAGTTGCCGAAGCAATTCATGTCGGAGCTTACTGCCCACTCAGG
TGAACGCATTGAGGAGAACGGTGAATTCATCTATGTATCCACTCAACGGGTAACAAAAAATGTCTACGATTCATATCATA
TTCGGGAAGCGATGATCAAGGGCTACGTGGAAATGTCGCAGATCAACCTGTCGATTGCCTGCGAATGTTCGCACGCTGAG
TACGAAGCGGAGCACACGACAGTGCAACTCGTAAGCGGAGGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1C7EC77

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7DXF0

References