Detailed information of TA system TA089786

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sanaTA/AbiEii-DUF6088
• Location: 1692547..1693192
• Replicon: chromosome
• Accession: NZ_CP025115
• Organism: Alteromonas sp. MB-3u-76

Toxin (Protein)

• Gene name: sanaT
• Uniprot ID: -
• Locus tag: CW735_RS07590
• Protein ID: WP_083595269.1
• Coordinates: 1692932..1693192 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: sanaA
• Uniprot ID: A0A2K8XZ52
• Locus tag: CW735_RS07585
• Protein ID: WP_071979919.1
• Coordinates: 1692547..1692951 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CW735_RS07570	1688036..1689115	+	1080	WP_071979922.1	Fic family protein	-
CW735_RS07575	1689144..1690754	+	1611	WP_071979921.1	N-6 DNA methylase	-
CW735_RS07580	1690754..1692097	+	1344	WP_071979920.1	restriction endonuclease subunit S	-
CW735_RS07585	1692547..1692951	+	405	WP_071979919.1	S-adenosylhomocysteine hydrolase	Antitoxin
CW735_RS07590	1692932..1693192	+	261	WP_083595269.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
CW735_RS07595	1693170..1693844	-	675	WP_100971533.1	hypothetical protein	-
CW735_RS07600	1694105..1694749	+	645	WP_100971535.1	efflux RND transporter periplasmic adaptor subunit	-
CW735_RS07605	1694846..1696255	+	1410	WP_100970864.1	IS66 family transposase	-
CW735_RS07610	1696263..1696889	+	627	WP_157812660.1	efflux RND transporter periplasmic adaptor subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1694846..1696255	1409

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (34-76)

Antitoxin

• Protein of unknown function DUF6088 (7-130)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 9616.05 Da
• Isoelectric Point: 6.2105

>T89786 WP_083595269.1 NZ_CP025115:1692932-1693192 [Alteromonas sp. MB-3u-76]
VSTKLDSSLFVDVADAIGLGNPAIVEKDYYVVQLLRHLSIIEFEHHQLVFTGGTALAKSDIKTYRMSEDIDIKLVPNKVF
NNLPSR

Nucleotide

• Length: 261 bp

>T89786 NZ_CP025115:1692932-1693192 [Alteromonas sp. MB-3u-76]
GTGTCAACGAAGCTCGATAGCTCGCTATTTGTCGATGTTGCCGACGCCATAGGGCTAGGCAACCCGGCAATTGTCGAAAA
GGACTACTATGTTGTCCAATTATTAAGGCACCTATCGATAATCGAATTCGAACACCACCAGTTGGTATTCACGGGCGGCA
CTGCACTTGCCAAGTCTGATATAAAAACGTATCGCATGTCGGAAGATATCGATATTAAGCTGGTTCCCAACAAGGTATTT
AATAATCTACCATCACGATAA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 15194.52 Da
• Isoelectric Point: 10.8456

>AT89786 WP_071979919.1 NZ_CP025115:1692547-1692951 [Alteromonas sp. MB-3u-76]
MTIQDRIKTRVKRSKRSVFLRSDFKDIADYDQVGRGLRNLAREGLLMKIGYGLYARARVNRITGKLMPDNAAGADGVLIE
AMERLDVDYKFDDLSNMNFSGQSTQIPASVKIVPTDPRFTRKITVGKQRVNEAR

Nucleotide

• Length: 405 bp

>AT89786 NZ_CP025115:1692547-1692951 [Alteromonas sp. MB-3u-76]
ATGACGATACAAGACAGAATAAAGACAAGAGTCAAGCGTTCTAAGCGTTCTGTTTTTTTGCGCTCTGATTTTAAAGATAT
AGCTGACTACGACCAAGTAGGTCGAGGCCTTAGAAATCTTGCTCGTGAAGGCTTGTTGATGAAGATAGGTTACGGGCTTT
ATGCCCGTGCCAGAGTCAATCGCATTACAGGTAAATTAATGCCGGATAATGCTGCGGGTGCTGATGGTGTACTAATAGAA
GCTATGGAAAGATTAGATGTAGACTACAAGTTCGATGATTTGTCGAACATGAACTTTTCAGGCCAGAGTACGCAAATTCC
AGCTAGTGTTAAAATTGTTCCAACCGATCCACGCTTTACCCGTAAAATTACCGTAGGTAAGCAGCGTGTCAACGAAGCTC
GATAG

Structures

Antitoxin

• AlphaFold DB: A0A2K8XZ52