Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 156374..156960 Replicon chromosome
Accession NZ_CP025096
Organism Spirosoma pollinicola strain Ha7

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CWM47_RS00640 Protein ID WP_100985882.1
Coordinates 156374..156757 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag CWM47_RS00645 Protein ID WP_100985883.1
Coordinates 156757..156960 (-) Length 68 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CWM47_RS00615 151406..152572 + 1167 WP_100985877.1 DUF2029 domain-containing protein -
CWM47_RS00620 152681..153436 - 756 WP_100985878.1 3-deoxy-manno-octulosonate cytidylyltransferase -
CWM47_RS00625 153508..154203 - 696 WP_100985879.1 phosphatase -
CWM47_RS00630 154294..155145 - 852 WP_100985880.1 3-deoxy-8-phosphooctulonate synthase -
CWM47_RS00635 155283..156380 - 1098 WP_100985881.1 iron-containing alcohol dehydrogenase -
CWM47_RS00640 156374..156757 - 384 WP_100985882.1 type II toxin-antitoxin system VapC family toxin Toxin
CWM47_RS00645 156757..156960 - 204 WP_100985883.1 DUF2281 domain-containing protein Antitoxin
CWM47_RS00650 156980..158176 - 1197 WP_100985884.1 DegT/DnrJ/EryC1/StrS family aminotransferase -
CWM47_RS00655 158354..158830 - 477 WP_100985885.1 nucleoside deaminase -
CWM47_RS00660 158854..159648 - 795 WP_100993673.1 hypothetical protein -
CWM47_RS00665 159743..160351 - 609 WP_100985886.1 hypothetical protein -
CWM47_RS00670 160394..160966 - 573 WP_100985887.1 NTP transferase domain-containing protein -
CWM47_RS00675 160959..161432 - 474 WP_100985888.1 cyclic pyranopterin monophosphate synthase MoaC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-121)

Antitoxin

Domain of unknown function DUF2281

(6-66)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14761.97 Da        Isoelectric Point: 5.1165

>T89781 WP_100985882.1 NZ_CP025096:c156757-156374 [Spirosoma pollinicola]
MRLLLDTHTLLWFYSGDEALSNNLRETIKSPANACFISIASLWEITIKVSLGKLELNTSILELFDFLERNQFWVLPIEFN
HLVELQRLPNHHRDPFDRLIIAQALAENLAVATRDSFFSQYGLTITW

Download         Length: 384 bp

>T89781 NZ_CP025096:c156757-156374 [Spirosoma pollinicola]
ATGCGCCTACTACTTGATACGCACACATTACTCTGGTTTTATAGCGGTGATGAAGCACTGTCTAACAACCTTAGAGAGAC
GATTAAGAGTCCTGCAAATGCTTGTTTTATAAGTATTGCAAGCTTGTGGGAAATAACTATCAAAGTGAGTTTAGGGAAAC
TGGAACTCAATACATCAATACTCGAATTGTTTGATTTTCTGGAACGCAATCAATTTTGGGTGCTTCCAATCGAATTTAAT
CATTTGGTAGAACTACAGCGATTACCGAATCACCACCGTGATCCGTTTGATCGTCTTATCATTGCACAAGCGTTAGCTGA
AAATTTAGCTGTCGCCACAAGAGATTCATTTTTCAGCCAGTATGGCTTAACGATAACATGGTAG

Antitoxin


Download         Length: 68 a.a.        Molecular weight: 7626.68 Da        Isoelectric Point: 4.5557

>AT89781 WP_100985883.1 NZ_CP025096:c156960-156757 [Spirosoma pollinicola]
MSTTALLSEIVALPPELRREVEDFVAFLRTKKQATTAPAEREFGYAKGKVRLSDDFDAPLDDFKEYM

Download         Length: 204 bp

>AT89781 NZ_CP025096:c156960-156757 [Spirosoma pollinicola]
ATGTCAACGACAGCCTTACTTTCCGAAATTGTAGCCTTACCGCCCGAGTTACGTCGTGAGGTTGAAGACTTCGTTGCCTT
TCTGCGAACCAAAAAGCAAGCCACGACAGCACCTGCAGAACGAGAGTTTGGCTATGCGAAAGGGAAGGTAAGGCTGTCTG
ATGATTTCGATGCGCCCCTGGACGATTTTAAGGAATACATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References