Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4150889..4151514 Replicon chromosome
Accession NZ_CP025085
Organism Serratia sp. ATCC 39006 strain LacA

Toxin (Protein)


Gene name Hha Uniprot ID A0A2I5TN77
Locus tag CWC46_RS18875 Protein ID WP_021014990.1
Coordinates 4151311..4151514 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A2I5TN67
Locus tag CWC46_RS18870 Protein ID WP_021014991.1
Coordinates 4150889..4151257 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CWC46_RS18860 4148771..4149781 - 1011 Protein_3644 IS4 family transposase -
CWC46_RS18870 4150889..4151257 + 369 WP_021014991.1 Hha toxicity modulator TomB Antitoxin
CWC46_RS18875 4151311..4151514 + 204 WP_021014990.1 hemolysin expression modulator Hha Toxin
CWC46_RS18885 4152110..4152442 + 333 WP_173861218.1 MGMT family protein -
CWC46_RS18890 4152798..4153661 + 864 WP_021014988.1 acyl-CoA thioesterase II -
CWC46_RS18895 4153742..4155028 - 1287 WP_021014987.1 ammonium transporter AmtB -
CWC46_RS18900 4155070..4155408 - 339 WP_002208627.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8117.51 Da        Isoelectric Point: 8.8500

>T89775 WP_021014990.1 NZ_CP025085:4151311-4151514 [Serratia sp. ATCC 39006]
MKKIDYLMRLRKCTSIDTLERVIEKNKYELSNDELEMFYSAADHRLAELTMNKLYDKVPVAVWKYVR

Download         Length: 204 bp

>T89775 NZ_CP025085:4151311-4151514 [Serratia sp. ATCC 39006]
ATGAAAAAAATCGATTATTTGATGCGTTTACGTAAATGCACCTCCATCGACACACTTGAGCGTGTTATTGAAAAAAACAA
GTACGAACTTTCAAACGACGAGTTAGAAATGTTCTATTCTGCAGCTGACCACCGCCTGGCCGAGCTGACTATGAATAAGC
TTTATGACAAGGTTCCTGTTGCTGTTTGGAAATACGTACGCTAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14305.08 Da        Isoelectric Point: 4.7721

>AT89775 WP_021014991.1 NZ_CP025085:4150889-4151257 [Serratia sp. ATCC 39006]
MDEYSPKHYDIAQLRFLCENLRDESIATLGDSSHGWVNDPTSAVNLQLNELIEHIAAFIVTYKIKYPNDEELCERVEKYL
DDTYILFSNYGINDGELRRWQKSRSQLFRMFSEKSICTAVKT

Download         Length: 369 bp

>AT89775 NZ_CP025085:4150889-4151257 [Serratia sp. ATCC 39006]
ATGGATGAGTACTCACCTAAACATTATGATATTGCCCAACTCAGATTCTTATGTGAAAATCTGCGCGATGAAAGTATCGC
TACGTTAGGTGACAGTAGCCATGGCTGGGTTAATGACCCTACGTCGGCTGTCAATCTTCAGCTAAATGAACTTATTGAAC
ATATAGCTGCATTTATTGTCACCTATAAAATTAAATACCCGAACGACGAAGAACTTTGCGAGCGGGTTGAAAAATACCTA
GACGATACCTATATTCTTTTTAGTAACTATGGCATCAATGATGGCGAGTTACGTAGATGGCAGAAATCCAGGTCACAATT
ATTCAGAATGTTCTCGGAAAAGAGCATCTGTACGGCAGTCAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I5TN77

Antitoxin

Source ID Structure
AlphaFold DB A0A2I5TN67

References