Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 923883..925566 Replicon chromosome
Accession NZ_CP025085
Organism Serratia sp. ATCC 39006 strain LacA

Toxin (Protein)


Gene name mosT Uniprot ID A0A2I5TFR0
Locus tag CWC46_RS04260 Protein ID WP_021013440.1
Coordinates 923883..924800 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A0A2I5TFR6
Locus tag CWC46_RS04265 Protein ID WP_037380309.1
Coordinates 924793..925566 (-) Length 258 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CWC46_RS04235 919011..919856 + 846 WP_021013443.1 ABC transporter permease subunit -
CWC46_RS04240 919919..920959 - 1041 WP_021013442.1 aldo/keto reductase -
CWC46_RS04245 921304..922623 - 1320 WP_021013441.1 serine dehydratase subunit alpha family protein -
CWC46_RS04260 923883..924800 - 918 WP_021013440.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
CWC46_RS04265 924793..925566 - 774 WP_037380309.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
CWC46_RS04270 926368..927207 + 840 WP_021013437.1 AraC family transcriptional regulator -
CWC46_RS04275 927345..927953 - 609 WP_021013435.1 LysE family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-93)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34623.79 Da        Isoelectric Point: 5.0933

>T89771 WP_021013440.1 NZ_CP025085:c924800-923883 [Serratia sp. ATCC 39006]
MDKHSPYYRQVELLLSALPVVASERCFALKGGTAINLFVRDFPRLSVDIDLAYIPLESRDVALPNVRAALTRIAEIQQQQ
AGISAVLQTNNPDEMRIIVSSPEAQIKIEVSPVTRGTLYPPEERDVVEAVDDEFGFATIQVVSLADLYGGKLCAALDRQH
PRDFYDVKMLLETQGIDRHIFNGFITYLLGHPRPLSEVLNPRWKDISLPYANEFNGMTFDAISLEELNAIPKLMVTALKA
QFTQRDYDFLMSFKRGEPDWNLAPEDQIQHLPAVRWKLRNIGRIPKDKHIQALAKLETVLAEWIE

Download         Length: 918 bp

>T89771 NZ_CP025085:c924800-923883 [Serratia sp. ATCC 39006]
ATGGATAAGCATTCACCTTATTATCGGCAAGTTGAGTTGCTGCTCAGTGCATTACCTGTTGTGGCATCAGAGCGATGCTT
TGCACTAAAAGGTGGGACGGCGATAAACTTGTTTGTTCGTGATTTCCCACGATTATCGGTTGATATCGATTTGGCTTACA
TTCCTCTGGAAAGCAGAGATGTGGCATTGCCAAATGTGCGGGCTGCTTTGACGCGTATTGCAGAAATACAGCAACAACAG
GCGGGCATTTCGGCGGTGCTACAAACGAATAATCCTGATGAAATGCGTATTATTGTCTCTTCTCCGGAGGCACAGATAAA
GATAGAAGTTTCGCCTGTTACGCGAGGTACACTGTATCCCCCGGAAGAACGTGATGTTGTTGAGGCGGTAGACGACGAGT
TCGGTTTTGCTACTATTCAGGTTGTATCACTTGCAGATCTCTATGGTGGCAAGCTTTGCGCTGCTCTGGATAGGCAACAC
CCCCGCGATTTTTATGACGTCAAAATGCTGCTCGAAACGCAAGGTATCGATCGCCACATCTTTAATGGTTTCATCACCTA
TCTACTGGGACACCCGCGCCCATTATCAGAGGTACTAAATCCCCGCTGGAAAGATATTTCTCTACCATATGCAAATGAAT
TTAATGGGATGACATTCGATGCGATCTCTCTGGAAGAACTCAATGCGATACCCAAATTAATGGTTACTGCTCTCAAAGCA
CAATTCACGCAGCGGGATTATGATTTTCTGATGTCTTTCAAACGTGGTGAGCCGGACTGGAATCTCGCTCCTGAAGACCA
GATTCAGCATCTACCAGCGGTTAGGTGGAAGTTACGAAATATTGGTCGGATACCAAAAGATAAACATATTCAGGCGTTGG
CGAAGCTTGAGACAGTTCTTGCCGAGTGGATAGAGTAG

Antitoxin


Download         Length: 258 a.a.        Molecular weight: 28873.29 Da        Isoelectric Point: 9.9461

>AT89771 WP_037380309.1 NZ_CP025085:c925566-924793 [Serratia sp. ATCC 39006]
MSSKLNWLLQKTAPGSLILQSWLTKNGISPSLANKYMHSDWLQKLRAGVYVRSGRDPQWSDAVLCLQNQLGISVHLAGLT
SLTYQGRSHYLHLTRQAIWLCVEDKASLPKWFKEFPNVEWLLLSNQKLNMHDEKYLTEVEIKGGRLKASVPELAAYEIAN
AVPGSLSFEHAAELFQGLVNLSPRKVELLLQSSRAVQTNRLYLFLADHYAHAWVKRIDKANIDLGAGKRQIVSGGKLDPK
YQITVPESFVSKGISHG

Download         Length: 774 bp

>AT89771 NZ_CP025085:c925566-924793 [Serratia sp. ATCC 39006]
ATGTCATCAAAGTTAAACTGGCTTTTGCAGAAAACTGCGCCAGGTTCCTTGATATTACAGTCCTGGCTGACAAAAAATGG
TATCAGCCCTTCTTTAGCCAATAAGTATATGCACAGCGACTGGTTACAAAAGCTACGTGCCGGGGTATACGTGCGGAGTG
GGCGCGACCCTCAGTGGAGTGATGCCGTCCTATGCCTCCAAAATCAGCTTGGGATTTCTGTTCATCTGGCGGGGCTTACT
AGCCTGACCTATCAGGGACGCTCTCATTATCTTCACTTAACACGCCAGGCGATTTGGCTTTGCGTAGAAGATAAAGCTTC
ATTGCCAAAATGGTTCAAAGAATTTCCCAATGTCGAGTGGCTTTTACTTTCTAACCAGAAGCTCAATATGCATGACGAAA
AATATCTGACAGAGGTTGAAATTAAAGGAGGGCGGTTGAAAGCGAGTGTGCCGGAATTAGCTGCTTACGAGATTGCTAAT
GCAGTCCCTGGTTCACTTTCATTTGAGCACGCAGCGGAGCTGTTTCAGGGGCTGGTAAACCTGAGTCCGCGTAAAGTCGA
ATTGTTGTTACAGTCCAGTCGAGCAGTGCAAACTAACCGGCTTTACCTGTTTCTGGCCGATCACTATGCTCATGCATGGG
TTAAGCGGATAGATAAAGCCAACATTGACTTGGGGGCTGGGAAACGGCAGATCGTATCTGGTGGCAAGCTAGACCCAAAA
TATCAGATCACTGTTCCAGAGAGTTTTGTTAGCAAAGGGATCTCGCATGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I5TFR0

Antitoxin

Source ID Structure
AlphaFold DB A0A2I5TFR6

References