Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) sdenTA/AbiEii(toxin)
Location 243531..244971 Replicon chromosome
Accession NZ_CP025084
Organism Serratia sp. ATCC 39006

Toxin (Protein)


Gene name sdenT Uniprot ID A0A2I5TE73
Locus tag SER39006_RS01120 Protein ID WP_021014005.1
Coordinates 243531..244418 (-) Length 296 a.a.

Antitoxin (Protein)


Gene name sdenA Uniprot ID A0A2I5T1U3
Locus tag SER39006_RS01125 Protein ID WP_021014004.1
Coordinates 244447..244971 (-) Length 175 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SER39006_RS01100 239833..239961 - 129 WP_021014009.1 AlpA family phage regulatory protein -
SER39006_RS01105 240323..241426 + 1104 WP_021014008.1 Fic family protein -
SER39006_RS01110 241548..242798 - 1251 WP_021014007.1 type II toxin-antitoxin system HipA family toxin -
SER39006_RS01115 242795..243100 - 306 WP_173861213.1 helix-turn-helix domain-containing protein -
SER39006_RS01120 243531..244418 - 888 WP_021014005.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
SER39006_RS01125 244447..244971 - 525 WP_021014004.1 DUF4095 domain-containing protein Antitoxin
SER39006_RS01130 245243..246415 + 1173 WP_021014003.1 methyltransferase domain-containing protein -
SER39006_RS01135 246428..247546 - 1119 WP_021014002.1 hypothetical protein -
SER39006_RS01140 247557..248561 - 1005 WP_021014001.1 SEC-C domain-containing protein -
SER39006_RS01145 248580..249929 - 1350 WP_021014000.1 type II toxin-antitoxin system HipA family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(36-265)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 296 a.a.        Molecular weight: 34205.23 Da        Isoelectric Point: 6.1070

>T89757 WP_021014005.1 NZ_CP025084:c244418-243531 [Serratia sp. ATCC 39006]
MLKQQIRQIVQSNPDYAAVTPVIEKEILHHDIMDVLIKQGVMQRLTFIGGTSLRMCYNSSRLSEDLDFNGGHDFKPSEFE
GLESEIQTYIQNKYETEVWVNKPSGEQQGDTVSWKISIVKEPNRPDLPRQKMHIDVCAIPSFDIEKRPLINHYDIVVPTE
GILVPVQSLQETLADKLIALAYRARRIKPRDIWDIVWIKQRGIDLSKILVEKKLNARHKQTDDFRQALSTSLAKLMSEEE
VHNDFNMEMSRFIPKQIKERTLDNPEYWAYVQGEVKAIAFELLHDCTPKNPFDMG

Download         Length: 888 bp

>T89757 NZ_CP025084:c244418-243531 [Serratia sp. ATCC 39006]
ATGCTGAAGCAACAAATTCGCCAAATCGTACAGTCAAACCCTGACTATGCAGCAGTCACGCCCGTGATAGAAAAAGAGAT
CTTGCATCATGACATTATGGACGTGCTGATCAAGCAAGGCGTTATGCAGCGATTAACCTTTATTGGCGGCACCTCATTAC
GCATGTGTTACAACAGCAGTAGGTTGTCAGAAGATCTTGATTTCAACGGTGGCCATGACTTCAAACCATCCGAGTTTGAG
GGGCTGGAGTCCGAGATACAGACTTATATTCAAAATAAGTATGAAACTGAAGTTTGGGTAAACAAGCCCTCTGGCGAGCA
GCAAGGGGATACCGTTTCGTGGAAGATTAGTATAGTGAAAGAGCCTAATCGTCCTGATTTACCAAGACAAAAAATGCATA
TTGACGTCTGTGCAATACCCTCATTCGATATCGAAAAGCGTCCGTTAATCAATCATTACGACATTGTTGTGCCGACTGAA
GGCATCTTGGTTCCTGTTCAATCACTACAAGAAACACTGGCCGATAAGCTTATTGCGTTAGCGTATCGAGCAAGGCGTAT
CAAGCCTCGTGATATCTGGGATATTGTTTGGATTAAGCAGCGCGGGATTGATTTATCCAAGATATTGGTTGAAAAGAAAC
TAAACGCCCGACACAAGCAAACAGATGACTTTCGACAGGCGCTGTCTACTTCGTTAGCCAAGCTAATGTCGGAAGAGGAA
GTACACAATGACTTCAATATGGAAATGAGCCGTTTTATCCCTAAGCAAATTAAAGAGAGAACCTTAGATAACCCAGAGTA
TTGGGCATACGTTCAGGGTGAGGTAAAAGCCATCGCGTTTGAGCTACTTCATGATTGCACACCAAAAAATCCATTTGATA
TGGGCTAG

Antitoxin


Download         Length: 175 a.a.        Molecular weight: 19441.75 Da        Isoelectric Point: 9.8254

>AT89757 WP_021014004.1 NZ_CP025084:c244971-244447 [Serratia sp. ATCC 39006]
MAKSDELLNVFAKAVRAGGGVHSATELAFMLGVPCGPAFRKLLADSVKKGLLRRVVKGFYESMITPPEPETAIYKIIKKL
RSGVLNYISLESQLSYTGDISQIVMGRITVVTKGRSGCFDTPYGVIEFTHTKRPVEQIAPNLYYDPDIKMYRAFKEQAIA
DLKHCRRNLHMLES

Download         Length: 525 bp

>AT89757 NZ_CP025084:c244971-244447 [Serratia sp. ATCC 39006]
ATGGCAAAATCTGATGAGCTACTAAACGTATTCGCGAAAGCGGTTCGCGCTGGTGGAGGCGTTCACAGTGCAACTGAGCT
TGCTTTTATGTTGGGTGTGCCCTGTGGCCCTGCTTTTAGAAAACTCCTAGCAGATAGCGTAAAGAAGGGCTTGCTAAGAC
GGGTGGTGAAAGGGTTCTATGAAAGTATGATTACACCCCCTGAGCCTGAGACGGCTATTTATAAAATCATCAAAAAGTTA
CGTAGTGGGGTATTGAATTACATCAGCTTAGAAAGCCAGCTCAGTTATACCGGCGATATTTCGCAAATTGTGATGGGCAG
GATCACGGTGGTGACTAAAGGTCGAAGTGGTTGTTTTGATACGCCTTATGGCGTGATCGAATTTACTCACACTAAAAGGC
CAGTCGAACAAATCGCCCCTAATTTGTATTATGACCCCGACATCAAAATGTATCGCGCATTCAAAGAGCAAGCGATTGCA
GATCTAAAGCACTGCCGCCGCAATCTACATATGCTGGAGAGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I5TE73

Antitoxin

Source ID Structure
AlphaFold DB A0A2I5T1U3

References