Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | IV | Classification (family/domain) | sdenTA/AbiEii(toxin) |
Location | 243531..244971 | Replicon | chromosome |
Accession | NZ_CP025084 | ||
Organism | Serratia sp. ATCC 39006 |
Toxin (Protein)
Gene name | sdenT | Uniprot ID | A0A2I5TE73 |
Locus tag | SER39006_RS01120 | Protein ID | WP_021014005.1 |
Coordinates | 243531..244418 (-) | Length | 296 a.a. |
Antitoxin (Protein)
Gene name | sdenA | Uniprot ID | A0A2I5T1U3 |
Locus tag | SER39006_RS01125 | Protein ID | WP_021014004.1 |
Coordinates | 244447..244971 (-) | Length | 175 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
SER39006_RS01100 | 239833..239961 | - | 129 | WP_021014009.1 | AlpA family phage regulatory protein | - |
SER39006_RS01105 | 240323..241426 | + | 1104 | WP_021014008.1 | Fic family protein | - |
SER39006_RS01110 | 241548..242798 | - | 1251 | WP_021014007.1 | type II toxin-antitoxin system HipA family toxin | - |
SER39006_RS01115 | 242795..243100 | - | 306 | WP_173861213.1 | helix-turn-helix domain-containing protein | - |
SER39006_RS01120 | 243531..244418 | - | 888 | WP_021014005.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
SER39006_RS01125 | 244447..244971 | - | 525 | WP_021014004.1 | DUF4095 domain-containing protein | Antitoxin |
SER39006_RS01130 | 245243..246415 | + | 1173 | WP_021014003.1 | methyltransferase domain-containing protein | - |
SER39006_RS01135 | 246428..247546 | - | 1119 | WP_021014002.1 | hypothetical protein | - |
SER39006_RS01140 | 247557..248561 | - | 1005 | WP_021014001.1 | SEC-C domain-containing protein | - |
SER39006_RS01145 | 248580..249929 | - | 1350 | WP_021014000.1 | type II toxin-antitoxin system HipA family toxin | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 296 a.a. Molecular weight: 34205.23 Da Isoelectric Point: 6.1070
>T89757 WP_021014005.1 NZ_CP025084:c244418-243531 [Serratia sp. ATCC 39006]
MLKQQIRQIVQSNPDYAAVTPVIEKEILHHDIMDVLIKQGVMQRLTFIGGTSLRMCYNSSRLSEDLDFNGGHDFKPSEFE
GLESEIQTYIQNKYETEVWVNKPSGEQQGDTVSWKISIVKEPNRPDLPRQKMHIDVCAIPSFDIEKRPLINHYDIVVPTE
GILVPVQSLQETLADKLIALAYRARRIKPRDIWDIVWIKQRGIDLSKILVEKKLNARHKQTDDFRQALSTSLAKLMSEEE
VHNDFNMEMSRFIPKQIKERTLDNPEYWAYVQGEVKAIAFELLHDCTPKNPFDMG
MLKQQIRQIVQSNPDYAAVTPVIEKEILHHDIMDVLIKQGVMQRLTFIGGTSLRMCYNSSRLSEDLDFNGGHDFKPSEFE
GLESEIQTYIQNKYETEVWVNKPSGEQQGDTVSWKISIVKEPNRPDLPRQKMHIDVCAIPSFDIEKRPLINHYDIVVPTE
GILVPVQSLQETLADKLIALAYRARRIKPRDIWDIVWIKQRGIDLSKILVEKKLNARHKQTDDFRQALSTSLAKLMSEEE
VHNDFNMEMSRFIPKQIKERTLDNPEYWAYVQGEVKAIAFELLHDCTPKNPFDMG
Download Length: 888 bp
>T89757 NZ_CP025084:c244418-243531 [Serratia sp. ATCC 39006]
ATGCTGAAGCAACAAATTCGCCAAATCGTACAGTCAAACCCTGACTATGCAGCAGTCACGCCCGTGATAGAAAAAGAGAT
CTTGCATCATGACATTATGGACGTGCTGATCAAGCAAGGCGTTATGCAGCGATTAACCTTTATTGGCGGCACCTCATTAC
GCATGTGTTACAACAGCAGTAGGTTGTCAGAAGATCTTGATTTCAACGGTGGCCATGACTTCAAACCATCCGAGTTTGAG
GGGCTGGAGTCCGAGATACAGACTTATATTCAAAATAAGTATGAAACTGAAGTTTGGGTAAACAAGCCCTCTGGCGAGCA
GCAAGGGGATACCGTTTCGTGGAAGATTAGTATAGTGAAAGAGCCTAATCGTCCTGATTTACCAAGACAAAAAATGCATA
TTGACGTCTGTGCAATACCCTCATTCGATATCGAAAAGCGTCCGTTAATCAATCATTACGACATTGTTGTGCCGACTGAA
GGCATCTTGGTTCCTGTTCAATCACTACAAGAAACACTGGCCGATAAGCTTATTGCGTTAGCGTATCGAGCAAGGCGTAT
CAAGCCTCGTGATATCTGGGATATTGTTTGGATTAAGCAGCGCGGGATTGATTTATCCAAGATATTGGTTGAAAAGAAAC
TAAACGCCCGACACAAGCAAACAGATGACTTTCGACAGGCGCTGTCTACTTCGTTAGCCAAGCTAATGTCGGAAGAGGAA
GTACACAATGACTTCAATATGGAAATGAGCCGTTTTATCCCTAAGCAAATTAAAGAGAGAACCTTAGATAACCCAGAGTA
TTGGGCATACGTTCAGGGTGAGGTAAAAGCCATCGCGTTTGAGCTACTTCATGATTGCACACCAAAAAATCCATTTGATA
TGGGCTAG
ATGCTGAAGCAACAAATTCGCCAAATCGTACAGTCAAACCCTGACTATGCAGCAGTCACGCCCGTGATAGAAAAAGAGAT
CTTGCATCATGACATTATGGACGTGCTGATCAAGCAAGGCGTTATGCAGCGATTAACCTTTATTGGCGGCACCTCATTAC
GCATGTGTTACAACAGCAGTAGGTTGTCAGAAGATCTTGATTTCAACGGTGGCCATGACTTCAAACCATCCGAGTTTGAG
GGGCTGGAGTCCGAGATACAGACTTATATTCAAAATAAGTATGAAACTGAAGTTTGGGTAAACAAGCCCTCTGGCGAGCA
GCAAGGGGATACCGTTTCGTGGAAGATTAGTATAGTGAAAGAGCCTAATCGTCCTGATTTACCAAGACAAAAAATGCATA
TTGACGTCTGTGCAATACCCTCATTCGATATCGAAAAGCGTCCGTTAATCAATCATTACGACATTGTTGTGCCGACTGAA
GGCATCTTGGTTCCTGTTCAATCACTACAAGAAACACTGGCCGATAAGCTTATTGCGTTAGCGTATCGAGCAAGGCGTAT
CAAGCCTCGTGATATCTGGGATATTGTTTGGATTAAGCAGCGCGGGATTGATTTATCCAAGATATTGGTTGAAAAGAAAC
TAAACGCCCGACACAAGCAAACAGATGACTTTCGACAGGCGCTGTCTACTTCGTTAGCCAAGCTAATGTCGGAAGAGGAA
GTACACAATGACTTCAATATGGAAATGAGCCGTTTTATCCCTAAGCAAATTAAAGAGAGAACCTTAGATAACCCAGAGTA
TTGGGCATACGTTCAGGGTGAGGTAAAAGCCATCGCGTTTGAGCTACTTCATGATTGCACACCAAAAAATCCATTTGATA
TGGGCTAG
Antitoxin
Download Length: 175 a.a. Molecular weight: 19441.75 Da Isoelectric Point: 9.8254
>AT89757 WP_021014004.1 NZ_CP025084:c244971-244447 [Serratia sp. ATCC 39006]
MAKSDELLNVFAKAVRAGGGVHSATELAFMLGVPCGPAFRKLLADSVKKGLLRRVVKGFYESMITPPEPETAIYKIIKKL
RSGVLNYISLESQLSYTGDISQIVMGRITVVTKGRSGCFDTPYGVIEFTHTKRPVEQIAPNLYYDPDIKMYRAFKEQAIA
DLKHCRRNLHMLES
MAKSDELLNVFAKAVRAGGGVHSATELAFMLGVPCGPAFRKLLADSVKKGLLRRVVKGFYESMITPPEPETAIYKIIKKL
RSGVLNYISLESQLSYTGDISQIVMGRITVVTKGRSGCFDTPYGVIEFTHTKRPVEQIAPNLYYDPDIKMYRAFKEQAIA
DLKHCRRNLHMLES
Download Length: 525 bp
>AT89757 NZ_CP025084:c244971-244447 [Serratia sp. ATCC 39006]
ATGGCAAAATCTGATGAGCTACTAAACGTATTCGCGAAAGCGGTTCGCGCTGGTGGAGGCGTTCACAGTGCAACTGAGCT
TGCTTTTATGTTGGGTGTGCCCTGTGGCCCTGCTTTTAGAAAACTCCTAGCAGATAGCGTAAAGAAGGGCTTGCTAAGAC
GGGTGGTGAAAGGGTTCTATGAAAGTATGATTACACCCCCTGAGCCTGAGACGGCTATTTATAAAATCATCAAAAAGTTA
CGTAGTGGGGTATTGAATTACATCAGCTTAGAAAGCCAGCTCAGTTATACCGGCGATATTTCGCAAATTGTGATGGGCAG
GATCACGGTGGTGACTAAAGGTCGAAGTGGTTGTTTTGATACGCCTTATGGCGTGATCGAATTTACTCACACTAAAAGGC
CAGTCGAACAAATCGCCCCTAATTTGTATTATGACCCCGACATCAAAATGTATCGCGCATTCAAAGAGCAAGCGATTGCA
GATCTAAAGCACTGCCGCCGCAATCTACATATGCTGGAGAGCTAA
ATGGCAAAATCTGATGAGCTACTAAACGTATTCGCGAAAGCGGTTCGCGCTGGTGGAGGCGTTCACAGTGCAACTGAGCT
TGCTTTTATGTTGGGTGTGCCCTGTGGCCCTGCTTTTAGAAAACTCCTAGCAGATAGCGTAAAGAAGGGCTTGCTAAGAC
GGGTGGTGAAAGGGTTCTATGAAAGTATGATTACACCCCCTGAGCCTGAGACGGCTATTTATAAAATCATCAAAAAGTTA
CGTAGTGGGGTATTGAATTACATCAGCTTAGAAAGCCAGCTCAGTTATACCGGCGATATTTCGCAAATTGTGATGGGCAG
GATCACGGTGGTGACTAAAGGTCGAAGTGGTTGTTTTGATACGCCTTATGGCGTGATCGAATTTACTCACACTAAAAGGC
CAGTCGAACAAATCGCCCCTAATTTGTATTATGACCCCGACATCAAAATGTATCGCGCATTCAAAGAGCAAGCGATTGCA
GATCTAAAGCACTGCCGCCGCAATCTACATATGCTGGAGAGCTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2I5TE73 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2I5T1U3 |