Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 797626..798283 Replicon chromosome
Accession NZ_CP025080
Organism Klebsiella pneumoniae strain SGH10

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag SGH10_RS04105 Protein ID WP_002916310.1
Coordinates 797873..798283 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag SGH10_RS04100 Protein ID WP_002916312.1
Coordinates 797626..797892 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SGH10_RS04075 792834..794267 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
SGH10_RS04080 794386..795114 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
SGH10_RS04085 795164..795475 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
SGH10_RS04090 795639..796298 + 660 WP_002916317.1 hemolysin III family protein -
SGH10_RS04095 796397..797380 - 984 WP_014906951.1 tRNA-modifying protein YgfZ -
SGH10_RS04100 797626..797892 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
SGH10_RS04105 797873..798283 + 411 WP_002916310.1 protein YgfX Toxin
SGH10_RS04110 798290..798811 - 522 WP_002916308.1 flavodoxin FldB -
SGH10_RS04115 798912..799808 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
SGH10_RS04120 799831..800544 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
SGH10_RS04125 800550..802283 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T89737 WP_002916310.1 NZ_CP025080:797873-798283 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T89737 NZ_CP025080:797873-798283 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT89737 WP_002916312.1 NZ_CP025080:797626-797892 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT89737 NZ_CP025080:797626-797892 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References