Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/-
Location 1885882..1886500 Replicon chromosome
Accession NZ_CP025076
Organism Streptococcus pneumoniae strain BHN97x

Toxin (Protein)


Gene name relE Uniprot ID A0A4F7JJU4
Locus tag CWI64_RS10140 Protein ID WP_000385025.1
Coordinates 1885882..1886250 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0I9CGM3
Locus tag CWI64_RS10145 Protein ID WP_000105960.1
Coordinates 1886240..1886500 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CWI64_RS10105 1881241..1881711 + 471 WP_000335587.1 HIT family protein -
CWI64_RS10110 1881714..1882430 + 717 WP_000747771.1 M15 family metallopeptidase -
CWI64_RS11725 1882470..1882607 - 138 WP_001809964.1 hypothetical protein -
CWI64_RS10115 1882739..1883164 + 426 WP_001085809.1 50S ribosomal protein L11 -
CWI64_RS10120 1883372..1884061 + 690 WP_001085675.1 50S ribosomal protein L1 -
CWI64_RS10125 1884860..1884940 - 81 Protein_1841 UDP-galactopyranose mutase -
CWI64_RS10130 1884948..1885310 + 363 WP_000895070.1 protein-export chaperone SecB -
CWI64_RS10140 1885882..1886250 - 369 WP_000385025.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CWI64_RS10145 1886240..1886500 - 261 WP_000105960.1 hypothetical protein Antitoxin
CWI64_RS10150 1886825..1887817 + 993 WP_001240806.1 ATP-binding cassette domain-containing protein -
CWI64_RS10155 1887819..1888637 + 819 WP_000594189.1 ABC-2 family transporter protein -
CWI64_RS10160 1888639..1889424 + 786 WP_000760712.1 ABC transporter permease -
CWI64_RS10165 1889463..1889741 + 279 WP_001812029.1 hypothetical protein -
CWI64_RS10170 1889726..1889923 + 198 WP_001812028.1 hypothetical protein -
CWI64_RS11550 1890304..1890390 - 87 Protein_1850 UDP-galactopyranose mutase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 14633.92 Da        Isoelectric Point: 8.0387

>T89727 WP_000385025.1 NZ_CP025076:c1886250-1885882 [Streptococcus pneumoniae]
MDYKVRFTEQARQDLDDIFIYYSTEFSENIAKKVITRLQQITNLLIFSPEGGISFDHKIGYSLYPENMLRMIVSKQYLLF
YLIHEKEVHTLRIINSRTDYLNQLDHLFRTCRKLFSSQIISL

Download         Length: 369 bp

>T89727 NZ_CP025076:c1886250-1885882 [Streptococcus pneumoniae]
ATGGACTATAAAGTACGCTTCACAGAACAAGCCAGACAAGACTTAGACGATATCTTCATCTACTACTCCACAGAGTTCAG
TGAAAACATAGCCAAGAAAGTCATCACTCGTCTACAACAAATTACCAACCTACTCATCTTCTCACCAGAGGGCGGTATTA
GCTTTGATCATAAAATCGGATACTCCCTCTATCCAGAAAATATGCTCAGAATGATTGTCTCTAAACAATACCTGCTCTTT
TACCTCATTCATGAAAAAGAAGTCCATACCCTGAGAATTATCAACTCACGCACCGACTACCTAAACCAACTCGACCACCT
CTTTCGTACATGTAGGAAACTATTTTCCTCACAAATAATCTCATTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9809.13 Da        Isoelectric Point: 4.3322

>AT89727 WP_000105960.1 NZ_CP025076:c1886500-1886240 [Streptococcus pneumoniae]
MSTLTRDRVYNFCVNTQLFEEAKTILESKNISLSDALNLFVEQIVLEKGLTIKTADQPKAELDKGYQDIIEGRLYDADEV
FSKYGL

Download         Length: 261 bp

>AT89727 NZ_CP025076:c1886500-1886240 [Streptococcus pneumoniae]
ATGTCAACACTTACACGAGACCGAGTTTATAACTTCTGCGTCAATACTCAACTATTTGAAGAAGCAAAAACCATCCTAGA
AAGCAAAAACATCAGCCTTTCAGATGCCCTCAACCTCTTTGTAGAACAAATCGTCCTTGAAAAAGGTCTAACAATTAAAA
CAGCCGACCAACCCAAAGCAGAACTAGATAAAGGCTACCAAGATATCATCGAAGGGCGTCTCTACGACGCAGACGAGGTC
TTTTCAAAGTATGGACTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4F7JJU4

Antitoxin

Source ID Structure
AlphaFold DB A0A0I9CGM3

References