89724

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 325630..326128 Replicon chromosome
Accession NZ_CP025076
Organism Streptococcus pneumoniae strain BHN97x

Toxin (Protein)


Gene name relE Uniprot ID B1IC19
Locus tag CWI64_RS01665 Protein ID WP_001809704.1
Coordinates 325630..325884 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B1IC20
Locus tag CWI64_RS01670 Protein ID WP_000208080.1
Coordinates 325886..326128 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CWI64_RS01650 321023..323491 - 2469 WP_001152989.1 DNA gyrase subunit A -
CWI64_RS01655 323685..324671 + 987 WP_000204727.1 L-lactate dehydrogenase -
CWI64_RS01660 324931..325583 - 653 Protein_316 potassium channel family protein -
CWI64_RS01665 325630..325884 - 255 WP_001809704.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CWI64_RS01670 325886..326128 - 243 WP_000208080.1 hypothetical protein Antitoxin
CWI64_RS01675 326219..327028 - 810 WP_001289493.1 MBL fold metallo-hydrolase -
CWI64_RS01680 327030..328379 - 1350 WP_061645482.1 cell wall metabolism sensor histidine kinase VicK -
CWI64_RS01685 328372..329076 - 705 WP_000722076.1 response regulator transcription factor -
CWI64_RS01690 329131..330306 - 1176 WP_000886145.1 A/G-specific adenine glycosylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-84)

Antitoxin

Protein of unknown function DUF6290

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10098.79 Da        Isoelectric Point: 10.7632

>T89724 WP_001809704.1 NZ_CP025076:c325884-325630 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQTNVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Download         Length: 255 bp

>T89724 NZ_CP025076:c325884-325630 [Streptococcus pneumoniae]
TTGTATAAATTAGTTCCAACAAGACGTTTTATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAACCAATGTTTTGGAAGACCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTTGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9205.46 Da        Isoelectric Point: 4.0527

>AT89724 WP_000208080.1 NZ_CP025076:c326128-325886 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Download         Length: 243 bp

>AT89724 NZ_CP025076:c326128-325886 [Streptococcus pneumoniae]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853PEW4

Antitoxin

Source ID Structure
AlphaFold DB A0A064C2J7

References