Detailed information of TA system TA089708

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3381663..3382299
• Replicon: chromosome
• Accession: NZ_CP025070
• Organism: Bordetella parapertussis strain A005

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: Q7W5Z1
• Locus tag: CWR63_RS15980
• Protein ID: WP_010928914.1
• Coordinates: 3381663..3381845 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: Q7W5Z0
• Locus tag: CWR63_RS15985
• Protein ID: WP_010928915.1
• Coordinates: 3381907..3382299 (+)
• Length: 131 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CWR63_RS15955	3377237..3377914	+	678	WP_010928910.1	HAD-IA family hydrolase	-
CWR63_RS15960	3378132..3379319	+	1188	WP_010928911.1	MFS transporter	-
CWR63_RS15970	3379894..3381114	+	1221	WP_010928912.1	ISL3-like element IS1001 family transposase	-
CWR63_RS15980	3381663..3381845	+	183	WP_010928914.1	type II toxin-antitoxin system HicA family toxin	Toxin
CWR63_RS15985	3381907..3382299	+	393	WP_010928915.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
CWR63_RS15990	3382572..3383481	-	910	Protein_3138	LysR family transcriptional regulator	-
CWR63_RS15995	3383606..3384580	+	975	WP_010928916.1	tripartite tricarboxylate transporter substrate binding protein	-
CWR63_RS16000	3384615..3384974	+	360	WP_010928917.1	hypothetical protein	-
CWR63_RS16005	3385041..3386213	+	1173	WP_010928918.1	thiolase domain-containing protein	-
CWR63_RS16010	3386217..3386643	+	427	Protein_3142	OB-fold domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	3379894..3381114	1220

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6572.69 Da
• Isoelectric Point: 10.9062

>T89708 WP_010928914.1 NZ_CP025070:3381663-3381845 [Bordetella parapertussis]
MDGKELIKQLERSGWTLRSVKGSHHVFAHPDRPGHISVPHPKKDLGIGLLNSILKAAGLK

Nucleotide

• Length: 183 bp

>T89708 NZ_CP025070:3381663-3381845 [Bordetella parapertussis]
ATGGACGGCAAAGAACTGATCAAGCAGCTTGAGCGGTCCGGGTGGACACTGCGGAGCGTTAAGGGCTCCCACCACGTTTT
CGCCCACCCAGACCGCCCCGGACATATCAGCGTCCCTCACCCTAAAAAGGATCTCGGCATCGGACTACTAAACAGCATCC
TCAAAGCAGCTGGTTTGAAGTGA

Antitoxin

Protein

• Length: 131 a.a.
• Molecular weight: 14058.82 Da
• Isoelectric Point: 4.2876

>AT89708 WP_010928915.1 NZ_CP025070:3381907-3382299 [Bordetella parapertussis]
VKYPIAIEPGSDTRAWGVVVPDLPGCFSAADEGIDQAIENAKEAIELWIETAIDSGAPIPAATNIANHQANPEFANWIWA
IADVDPAVLDETVERVNITIPRRILKRLDDRARAAGESRSSYIAHLAMTA

Nucleotide

• Length: 393 bp

>AT89708 NZ_CP025070:3381907-3382299 [Bordetella parapertussis]
GTGAAATATCCCATTGCCATTGAACCCGGCAGCGACACGCGCGCCTGGGGAGTCGTTGTTCCTGATCTGCCCGGCTGCTT
TTCCGCAGCGGACGAAGGGATTGATCAAGCAATCGAGAACGCCAAGGAAGCCATTGAGTTGTGGATTGAAACGGCCATCG
ACTCCGGCGCCCCCATTCCTGCGGCAACCAACATAGCCAATCATCAGGCCAATCCTGAGTTCGCCAACTGGATTTGGGCG
ATTGCTGATGTCGATCCTGCAGTCTTGGATGAAACTGTCGAGCGCGTGAACATCACAATCCCGCGCCGAATTCTCAAGCG
CCTGGATGATCGCGCCCGCGCCGCCGGCGAAAGCCGGAGCAGCTACATCGCACATCTCGCCATGACTGCCTGA

Structures

Toxin

• AlphaFold DB: Q7W5Z1

Antitoxin

• AlphaFold DB: Q7W5Z0