Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 2808829..2809490 Replicon chromosome
Accession NZ_CP025069
Organism Bordetella bronchiseptica strain I124

Toxin (Protein)


Gene name vapC Uniprot ID A0A807E2K1
Locus tag CWR61_RS13400 Protein ID WP_033448127.1
Coordinates 2809065..2809490 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A807E2N3
Locus tag CWR61_RS13395 Protein ID WP_033448129.1
Coordinates 2808829..2809068 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CWR61_RS13360 2803858..2804661 - 804 WP_015063708.1 bacteriocin family protein -
CWR61_RS13365 2804658..2805704 - 1047 WP_015063707.1 Dyp-type peroxidase -
CWR61_RS13370 2805782..2806342 - 561 WP_015063706.1 DUF488 domain-containing protein -
CWR61_RS13375 2806339..2806572 - 234 WP_033447348.1 DUF2945 domain-containing protein -
CWR61_RS13380 2806654..2807166 - 513 WP_033447345.1 redoxin domain-containing protein -
CWR61_RS13385 2807225..2807770 - 546 WP_015063704.1 peroxidase-related enzyme -
CWR61_RS13390 2807914..2808756 + 843 WP_033448135.1 AraC family transcriptional regulator -
CWR61_RS13395 2808829..2809068 + 240 WP_033448129.1 Arc family DNA-binding protein Antitoxin
CWR61_RS13400 2809065..2809490 + 426 WP_033448127.1 PIN domain-containing protein Toxin
CWR61_RS13405 2809600..2810064 + 465 WP_033448125.1 MarR family transcriptional regulator -
CWR61_RS13410 2810161..2811666 - 1506 WP_033448123.1 tripartite tricarboxylate transporter permease -
CWR61_RS13415 2812165..2812677 + 513 WP_033448121.1 hypothetical protein -
CWR61_RS13420 2812697..2813671 - 975 WP_068926360.1 tripartite tricarboxylate transporter substrate binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-121)

Antitoxin

Arc-like DNA binding domain

(9-46)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 14904.22 Da        Isoelectric Point: 5.4757

>T89703 WP_033448127.1 NZ_CP025069:2809065-2809490 [Bordetella bronchiseptica]
MILLDTDVLLEPLRPAPDPAVAAWLDAQHVETLYLAALSVAEIQLGLARLPRGKRAETLRHEFERRILPLFMGHVLPFDA
AAADAYAAVMTQAAAAGHALDAIDGCIAATATAHGLAIATRHPARFEAAGLTAIDPWQAAV

Download         Length: 426 bp

>T89703 NZ_CP025069:2809065-2809490 [Bordetella bronchiseptica]
ATGATCCTGCTCGATACCGACGTGCTGCTCGAACCGCTGCGGCCGGCCCCCGACCCGGCCGTCGCGGCATGGCTGGATGC
CCAGCACGTCGAGACCCTGTACCTGGCCGCGCTCAGCGTGGCCGAGATCCAGCTCGGGCTGGCTCGCCTGCCGCGCGGCA
AGCGGGCCGAGACGCTGCGCCACGAATTCGAGCGGCGCATCCTGCCCCTGTTCATGGGCCATGTCCTGCCTTTCGACGCG
GCCGCGGCCGATGCCTATGCCGCCGTCATGACGCAAGCCGCGGCGGCCGGCCATGCGCTGGACGCGATCGACGGCTGCAT
CGCCGCCACCGCCACCGCGCACGGCCTGGCCATCGCCACGCGCCACCCGGCCCGCTTCGAAGCCGCCGGGCTCACCGCCA
TCGACCCCTGGCAAGCCGCCGTTTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8535.74 Da        Isoelectric Point: 11.5658

>AT89703 WP_033448129.1 NZ_CP025069:2808829-2809068 [Bordetella bronchiseptica]
VSSITVRNVPEEVHRALRVRAATHGRSTEAEIRAILENAVLPDGRVKLGTLLSHIGRGARGMDLTIERNPAPARAASFE

Download         Length: 240 bp

>AT89703 NZ_CP025069:2808829-2809068 [Bordetella bronchiseptica]
GTGTCTTCGATTACGGTAAGAAATGTTCCCGAGGAAGTGCATCGCGCCTTGCGCGTGCGCGCCGCCACGCATGGGCGCAG
CACCGAGGCCGAGATCCGCGCCATCCTGGAAAACGCCGTGCTGCCCGACGGGCGCGTCAAGCTGGGCACCCTGCTCAGCC
ACATCGGCCGCGGCGCGCGCGGCATGGATCTGACCATCGAACGCAACCCGGCGCCCGCCCGCGCGGCCAGCTTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A807E2K1

Antitoxin

Source ID Structure
AlphaFold DB A0A807E2N3

References