Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 132719..133359 Replicon plasmid unnamed2
Accession NZ_CP025063
Organism Roseomonas mucosa strain PG

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HVPorG_RS21950 Protein ID WP_019463390.1
Coordinates 132719..133126 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HVPorG_RS21955 Protein ID WP_019463391.1
Coordinates 133123..133359 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVPorG_RS21925 (HVPorG_04490g) 129429..129674 + 246 Protein_130 IS21 family transposase -
HVPorG_RS21930 (HVPorG_04491f) 129674..130402 + 729 WP_115359213.1 IS21-like element helper ATPase IstB -
HVPorG_RS21935 (HVPorG_05037) 130408..130692 - 285 WP_265548233.1 hypothetical protein -
HVPorG_RS21940 (HVPorG_05036) 130801..131529 - 729 WP_075801102.1 hypothetical protein -
HVPorG_RS21945 (HVPorG_03205) 131607..132722 - 1116 WP_265548234.1 site-specific integrase -
HVPorG_RS21950 (HVPorG_03206) 132719..133126 - 408 WP_019463390.1 PIN domain-containing protein Toxin
HVPorG_RS21955 (HVPorG_03207) 133123..133359 - 237 WP_019463391.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
HVPorG_RS21960 (HVPorG_04622b) 133641..134771 + 1131 WP_265548235.1 helix-turn-helix domain-containing protein -
HVPorG_RS21965 (HVPorG_04623) 134921..135964 + 1044 WP_075822422.1 hypothetical protein -
HVPorG_RS21970 (HVPorG_04624) 135961..136269 + 309 WP_019463350.1 hypothetical protein -
HVPorG_RS21975 (HVPorG_04625) 136289..137104 + 816 WP_075822423.1 hypothetical protein -
HVPorG_RS21980 (HVPorG_05035) 137177..137422 - 246 WP_139323330.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..183675 183675


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-115)

Antitoxin

SpoVT-AbrB domain

(5-35)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14667.94 Da        Isoelectric Point: 5.8528

>T89690 WP_019463390.1 NZ_CP025063:c133126-132719 [Roseomonas mucosa]
MNRPFLDTNILLYAALQPDPRSETARGLLARGGLVSVQVLNEFTAVARRKLRRPWPEVMQALAAIRTLCPAPRPLTVATH
EAAVGLAERLGYTIYDALILASALEAGCDTLFSEDLQDGQVVEGQLTIRNPFAAP

Download         Length: 408 bp

>T89690 NZ_CP025063:c133126-132719 [Roseomonas mucosa]
ATGAACCGGCCCTTCCTCGATACCAACATCCTGCTCTACGCTGCCCTGCAGCCGGATCCGCGTTCCGAGACGGCGCGCGG
CCTCCTGGCCCGGGGCGGCCTGGTCAGCGTCCAGGTGCTCAACGAGTTCACCGCCGTCGCCCGCCGCAAGCTACGCCGGC
CCTGGCCCGAGGTCATGCAGGCGCTGGCCGCCATCCGGACTCTCTGTCCGGCGCCCCGGCCGCTCACCGTCGCGACGCAC
GAGGCGGCCGTTGGGCTGGCGGAGAGGCTGGGCTACACGATCTACGATGCCTTGATCCTGGCCTCGGCCCTGGAGGCCGG
CTGCGACACGCTCTTCTCCGAGGATCTGCAGGACGGGCAGGTGGTCGAAGGGCAACTGACCATCCGCAACCCCTTCGCCG
CGCCATGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8714.71 Da        Isoelectric Point: 5.7066

>AT89690 WP_019463391.1 NZ_CP025063:c133359-133123 [Roseomonas mucosa]
MQVSRWGNSLAVRLPAAVVEALGLREGDEVAIEVADSHTFRVARDRRRDEAIEALRGLGWHLPDGFRFSRDEANERGG

Download         Length: 237 bp

>AT89690 NZ_CP025063:c133359-133123 [Roseomonas mucosa]
ATGCAGGTCAGCCGCTGGGGCAACAGCCTCGCCGTTCGCCTCCCCGCCGCCGTGGTCGAGGCTTTGGGCCTGCGCGAGGG
CGACGAGGTCGCCATCGAGGTGGCCGACTCCCACACCTTCCGCGTGGCCCGCGACCGCCGCCGCGACGAGGCGATCGAGG
CGCTGCGCGGTCTCGGCTGGCACCTGCCCGACGGCTTCCGTTTCTCGCGCGACGAAGCCAACGAGCGTGGCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References