Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3919833..3920442 Replicon chromosome
Accession NZ_CP025048
Organism Escherichia coli strain SC516

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag CWI33_RS19900 Protein ID WP_001291435.1
Coordinates 3919833..3920051 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag CWI33_RS19905 Protein ID WP_100881972.1
Coordinates 3920077..3920442 (-) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CWI33_RS19865 3915122..3915694 + 573 WP_077580479.1 YbaY family lipoprotein -
CWI33_RS19870 3915725..3916036 - 312 WP_165369371.1 MGMT family protein -
CWI33_RS19880 3916415..3916768 + 354 WP_000878140.1 DUF1428 domain-containing protein -
CWI33_RS19885 3916810..3918360 - 1551 WP_072643403.1 cyclic-guanylate-specific phosphodiesterase PdeB -
CWI33_RS19890 3918524..3918994 - 471 WP_000136192.1 YlaC family protein -
CWI33_RS19895 3919110..3919661 - 552 WP_000102564.1 maltose O-acetyltransferase -
CWI33_RS19900 3919833..3920051 - 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
CWI33_RS19905 3920077..3920442 - 366 WP_100881972.1 Hha toxicity modulator TomB Antitoxin
CWI33_RS19910 3920435..3921132 - 698 Protein_3636 IS1 family transposase -
CWI33_RS19920 3921774..3924923 - 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(9-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T89645 WP_001291435.1 NZ_CP025048:c3920051-3919833 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T89645 NZ_CP025048:c3920051-3919833 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 14079.94 Da        Isoelectric Point: 4.6982

>AT89645 WP_100881972.1 NZ_CP025048:c3920442-3920077 [Escherichia coli]
INKLESLPAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYLDDT
FMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 366 bp

>AT89645 NZ_CP025048:c3920442-3920077 [Escherichia coli]
ATCAATAAGTTGGAGTCATTACCCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGCAAACCTTGA
AGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGCATATTGCGA
CCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTGGATGACACC
TTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACTATTCCGTTG
TTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure

References