89588

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2304469..2305087 Replicon chromosome
Accession NZ_CP025043
Organism Streptococcus suis strain AH681

Toxin (Protein)


Gene name relE Uniprot ID A0A116MJ73
Locus tag CWI26_RS11375 Protein ID WP_024377605.1
Coordinates 2304746..2305087 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2I5KRR3
Locus tag CWI26_RS11370 Protein ID WP_024377606.1
Coordinates 2304469..2304756 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CWI26_RS11345 2300761..2301684 - 924 WP_013730650.1 zinc ABC transporter substrate-binding protein -
CWI26_RS11350 2301810..2302469 + 660 WP_100881803.1 metal-dependent transcriptional regulator -
CWI26_RS11355 2302483..2302758 - 276 WP_032511325.1 hypothetical protein -
CWI26_RS11360 2302856..2303530 - 675 WP_100881805.1 CPBP family intramembrane metalloprotease -
CWI26_RS11365 2303593..2304243 - 651 WP_024377607.1 CPBP family intramembrane metalloprotease -
CWI26_RS11370 2304469..2304756 + 288 WP_024377606.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
CWI26_RS11375 2304746..2305087 + 342 WP_024377605.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CWI26_RS11380 2305181..2305375 - 195 WP_024377604.1 hypothetical protein -
CWI26_RS11385 2305397..2306098 - 702 WP_100881806.1 CPBP family intramembrane metalloprotease -
CWI26_RS11390 2306102..2306512 - 411 WP_100881807.1 hypothetical protein -
CWI26_RS11395 2306547..2306729 - 183 WP_024377601.1 hypothetical protein -
CWI26_RS12030 2306952..2307113 - 162 WP_153603303.1 hypothetical protein -
CWI26_RS12035 2308280..2308441 - 162 WP_153597537.1 hypothetical protein -
CWI26_RS12040 2308750..2308917 - 168 WP_158293418.1 hypothetical protein -
CWI26_RS12045 2308991..2309152 - 162 WP_153308666.1 hypothetical protein -
CWI26_RS11410 2309193..2309351 - 159 WP_002942002.1 hypothetical protein -
CWI26_RS11415 2309458..2309667 - 210 WP_044678691.1 hypothetical protein -
CWI26_RS12050 2309685..2309846 - 162 WP_153309488.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-100)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(11-90)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13071.05 Da        Isoelectric Point: 7.1990

>T89588 WP_024377605.1 NZ_CP025043:2304746-2305087 [Streptococcus suis]
MVYEVHLSAKAEQDLEEIYQYYVREFSESSARKVLASLSTAILTLEIFPEGYIDLDARLGQALFPEGKTRMIPGKQHLIF
YLIRGSRVDVLRIRGARTDYLNNLDNLFKQTLK

Download         Length: 342 bp

>T89588 NZ_CP025043:2304746-2305087 [Streptococcus suis]
ATGGTCTATGAAGTACATTTATCTGCTAAAGCCGAACAAGATTTAGAGGAAATCTACCAGTATTATGTCCGTGAATTTTC
AGAATCAAGTGCTCGAAAGGTGCTTGCATCTCTGAGCACAGCTATCTTGACCTTAGAAATATTTCCAGAGGGATATATTG
ACCTTGACGCTCGTCTGGGACAAGCATTATTCCCAGAAGGAAAAACAAGGATGATTCCTGGAAAACAGCACCTCATCTTC
TATTTGATTCGTGGCTCTCGTGTAGATGTCCTTCGCATTAGAGGAGCAAGGACAGACTACCTAAACAACCTAGACAATCT
ATTCAAGCAAACCCTCAAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10843.28 Da        Isoelectric Point: 4.1956

>AT89588 WP_024377606.1 NZ_CP025043:2304469-2304756 [Streptococcus suis]
MTGLVRDRQYNFRVNAQILEQAKIILSEKDMTLSDALNLFVERVVEEQDLPIKTVEEARAEAFLDELIAELDEGYQEVLS
GHTTPAREVFAKYGL

Download         Length: 288 bp

>AT89588 NZ_CP025043:2304469-2304756 [Streptococcus suis]
ATGACAGGATTGGTTAGGGATAGACAATATAATTTTAGAGTAAATGCACAAATACTGGAACAAGCAAAAATAATCTTATC
AGAAAAAGATATGACCCTTTCTGATGCTCTTAATTTATTTGTAGAAAGAGTGGTTGAAGAGCAAGATTTGCCAATAAAAA
CGGTAGAAGAGGCACGTGCAGAGGCTTTTCTAGATGAATTGATTGCAGAGCTTGATGAAGGCTACCAAGAAGTTTTATCA
GGACACACGACACCTGCTCGTGAGGTATTCGCCAAATATGGTCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A116MJ73

Antitoxin

Source ID Structure
AlphaFold DB A0A2I5KRR3

References