89587

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 2219796..2220402 Replicon chromosome
Accession NZ_CP025043
Organism Streptococcus suis strain AH681

Toxin (Protein)


Gene name parE Uniprot ID A0A2I5KRH7
Locus tag CWI26_RS10930 Protein ID WP_029187570.1
Coordinates 2219796..2220125 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A0Z8LVV9
Locus tag CWI26_RS10935 Protein ID WP_002940311.1
Coordinates 2220115..2220402 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CWI26_RS10900 2215369..2217099 - 1731 WP_024379287.1 membrane protein -
CWI26_RS10905 2217302..2218174 - 873 WP_024378763.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
CWI26_RS10910 2218193..2218723 - 531 WP_024419185.1 DUF1697 domain-containing protein -
CWI26_RS10915 2218737..2218994 - 258 WP_024419186.1 Txe/YoeB family addiction module toxin -
CWI26_RS10920 2218996..2219256 - 261 WP_029693774.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
CWI26_RS10925 2219332..2219787 - 456 WP_099870748.1 8-oxo-dGTP diphosphatase -
CWI26_RS10930 2219796..2220125 - 330 WP_029187570.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CWI26_RS10935 2220115..2220402 - 288 WP_002940311.1 hypothetical protein Antitoxin
CWI26_RS10940 2220500..2220868 - 369 WP_099875905.1 hypothetical protein -
CWI26_RS10945 2220861..2221430 - 570 WP_099875940.1 ribonuclease M5 -
CWI26_RS10950 2221414..2222196 - 783 WP_100881781.1 TatD family hydrolase -
CWI26_RS10955 2222304..2222441 - 138 WP_002939016.1 50S ribosomal protein L34 -
CWI26_RS10960 2222609..2223604 - 996 WP_044765292.1 protein jag -
CWI26_RS10965 2223624..2224436 - 813 WP_100881782.1 YidC/Oxa1 family membrane protein insertase -
CWI26_RS10970 2224420..2224779 - 360 WP_004194560.1 ribonuclease P protein component -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-96)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12563.50 Da        Isoelectric Point: 6.4768

>T89587 WP_029187570.1 NZ_CP025043:c2220125-2219796 [Streptococcus suis]
MEFESYSVMLAPAVEKELAAIYAYFSEQFSEEIAKRRIGVIIEALESLQIFPERGFNADNRFGKQIDPPHLTRGYVIGKD
YIALYRVVEKEVRVGHLFATKSDYVKLLK

Download         Length: 330 bp

>T89587 NZ_CP025043:c2220125-2219796 [Streptococcus suis]
ATGGAATTTGAGTCATATTCAGTGATGCTTGCTCCAGCAGTGGAGAAGGAATTGGCAGCTATTTACGCCTATTTCTCGGA
ACAGTTCTCAGAAGAAATTGCCAAAAGACGAATTGGGGTGATTATCGAAGCTTTGGAGAGTTTGCAAATTTTTCCTGAAC
GTGGCTTTAACGCCGATAACCGTTTTGGTAAGCAGATAGACCCGCCACATCTGACCCGAGGTTACGTTATTGGAAAAGAC
TACATTGCACTCTATCGTGTGGTTGAAAAAGAAGTGCGAGTTGGTCATCTCTTTGCGACCAAGAGTGATTATGTGAAGTT
GTTGAAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10911.52 Da        Isoelectric Point: 4.3472

>AT89587 WP_002940311.1 NZ_CP025043:c2220402-2220115 [Streptococcus suis]
MITIKKDAQVNFKTDSRLLEKAKEIFAMNQLDLTAGFNLFLQNIAVKNELPILTEEELEREELFLQLQKEIQENQQAIEA
GQGISLESVKEKYGI

Download         Length: 288 bp

>AT89587 NZ_CP025043:c2220402-2220115 [Streptococcus suis]
TTGATAACTATAAAAAAAGATGCCCAAGTAAATTTTAAAACTGACTCCAGACTTTTGGAAAAAGCCAAGGAAATATTTGC
TATGAACCAGTTGGATTTGACGGCTGGTTTCAATCTCTTTTTGCAAAACATTGCTGTAAAAAATGAGTTGCCAATTCTGA
CTGAAGAAGAGTTGGAAAGAGAAGAGTTATTTTTACAGCTTCAGAAGGAAATACAGGAAAACCAACAGGCGATTGAGGCA
GGTCAAGGGATCAGCCTAGAAAGTGTCAAAGAGAAGTATGGAATTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I5KRH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z8LVV9

References