Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 1257526..1258663 Replicon chromosome
Accession NZ_CP025043
Organism Streptococcus suis strain AH681

Toxin (Protein)


Gene name zeta Uniprot ID A0A2I5KP23
Locus tag CWI26_RS06215 Protein ID WP_074390287.1
Coordinates 1257526..1258389 (-) Length 288 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID R2XCR7
Locus tag CWI26_RS06220 Protein ID WP_000301765.1
Coordinates 1258391..1258663 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CWI26_RS06195 1253437..1253790 - 354 WP_100881395.1 PrgI family protein -
CWI26_RS06200 1253852..1254706 - 855 WP_001872352.1 conjugal transfer protein TrbL -
CWI26_RS06205 1254725..1254967 - 243 WP_001072172.1 hypothetical protein -
CWI26_RS06210 1254985..1256802 - 1818 WP_100881396.1 type IV secretory system conjugative DNA transfer family protein -
CWI26_RS11990 1256802..1256969 - 168 WP_158293403.1 hypothetical protein -
CWI26_RS11995 1256939..1257085 - 147 WP_153308682.1 hypothetical protein -
CWI26_RS06215 1257526..1258389 - 864 WP_074390287.1 zeta toxin family protein Toxin
CWI26_RS06220 1258391..1258663 - 273 WP_000301765.1 antitoxin Antitoxin
CWI26_RS06225 1258680..1258889 - 210 WP_000527317.1 peptide-binding protein -
CWI26_RS06230 1258987..1259883 - 897 WP_001809760.1 ParA family protein -
CWI26_RS06235 1259986..1260270 - 285 WP_073459356.1 topoisomerase DNA-binding C4 zinc finger domain-containing protein -
CWI26_RS06245 1260416..1261153 - 738 WP_001038796.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) -
CWI26_RS06250 1261278..1261373 - 96 WP_001809736.1 23S rRNA methyltransferase attenuation leader peptide -
CWI26_RS06255 1261447..1261737 - 291 Protein_1147 hypothetical protein -
CWI26_RS06260 1261814..1262398 - 585 WP_100881397.1 CPBP family intramembrane metalloprotease -
CWI26_RS06265 1262401..1262634 - 234 WP_014621275.1 hypothetical protein -
CWI26_RS06270 1262643..1263026 - 384 WP_014636638.1 hypothetical protein -
CWI26_RS06275 1263037..1263465 - 429 WP_100881398.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element tet(O) / erm(B) - 1195416..1291622 96206


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-214)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 288 a.a.        Molecular weight: 32477.97 Da        Isoelectric Point: 6.3643

>T89585 WP_074390287.1 NZ_CP025043:c1258389-1257526 [Streptococcus suis]
MANIVNFTDKQFENRLNDNLEELIQGKKAVESPTAFLLGGQPGSGKTSLRSAIFEETQGNVIVIDNDTFKQQHPNFDELV
KLYEKDVVKHVTPYSNRMTEAIISRLSDQGYNLVIEGTGRTTDVPIQTATMLQSKGYETKIYVMAVPKIESYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSSLETPSISPKETLERELNRKVSGKEIQ
PTLERIEQKMVQNQHQETPEFKAIQQKMESLQPPTPPIPKTPKLPGL

Download         Length: 864 bp

>T89585 NZ_CP025043:c1258389-1257526 [Streptococcus suis]
ATGGCAAATATAGTCAATTTTACTGACAAACAATTTGAGAATCGCTTAAATGATAATTTAGAAGAATTGATTCAAGGAAA
AAAAGCGGTTGAATCGCCAACCGCTTTTTTACTTGGTGGGCAACCAGGGTCAGGGAAAACCAGTTTGCGATCAGCAATTT
TTGAAGAAACACAAGGGAATGTTATTGTCATTGATAATGATACCTTTAAACAACAGCACCCTAATTTTGATGAACTAGTG
AAGCTTTATGAAAAAGACGTAGTAAAACACGTTACCCCTTATTCTAATCGCATGACAGAAGCGATCATAAGCCGTTTGAG
CGATCAAGGGTATAATTTGGTGATCGAAGGTACAGGACGAACAACAGACGTTCCTATTCAAACCGCAACAATGCTTCAAT
CTAAAGGTTATGAAACAAAAATATACGTCATGGCAGTACCGAAAATTGAATCATACTTAGGAACAATTGAACGATATGAA
ACCATGTATGCAGATGATCCAATGACAGCCAGGGCAACACCAAAACAAGCGCATGATATTGTTGTCAAAAACTTACCGAC
CAATTTAGAAACCCTTCATAAAACGGGCTTATTTAGCGATATAAGGCTTTACAATAGAGAAGGAGTGAAACTCTATTCAA
GCTTAGAAACGCCTTCCATTAGTCCGAAAGAGACCTTAGAAAGAGAATTAAATCGTAAAGTATCAGGGAAAGAAATTCAA
CCGACTTTGGAAAGAATAGAGCAAAAAATGGTTCAAAATCAACACCAAGAAACCCCTGAATTTAAAGCAATTCAACAAAA
AATGGAAAGCTTGCAGCCACCTACACCACCAATACCCAAAACACCTAAACTTCCAGGACTTTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10721.25 Da        Isoelectric Point: 6.4676

>AT89585 WP_000301765.1 NZ_CP025043:c1258663-1258391 [Streptococcus suis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDSQLLEVNLLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYS
KQVLNKEKVA

Download         Length: 273 bp

>AT89585 NZ_CP025043:c1258663-1258391 [Streptococcus suis]
ATGGCAGTTACTTATGAAAAAACATTTGAAATAGAGATCATTAACGAATTATCGGCAAGCGTTTATAATCGAGTATTAAA
CTATGTTTTGAATCATGAATTAAATAAAAATGACTCTCAATTATTGGAAGTCAATTTATTAAACCAATTAAAGCTTGCAA
AACGTGTAAATCTTTTTGATTATTCTTTAGAAGAATTACAAGCCGTTCATGAGTATTGGCGGTCAATGAATCGTTACTCA
AAACAAGTTTTGAATAAAGAGAAAGTGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I5KP23

Antitoxin

Source ID Structure
PDB 3Q8X
PDB 1GVN
AlphaFold DB A0A829F0A3

References