Detailed information of TA system TA089584

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sezT-pezT/zeta-couple_hipB
• Location: 1208842..1210103
• Replicon: chromosome
• Accession: NZ_CP025043
• Organism: Streptococcus suis strain AH681

Toxin (Protein)

• Gene name: sezT
• Uniprot ID: -
• Locus tag: CWI26_RS05985
• Protein ID: WP_100881383.1
• Coordinates: 1208842..1209627 (-)
• Length: 262 a.a.

Antitoxin (Protein)

• Gene name: pezT
• Uniprot ID: A0A0Z8GXZ9
• Locus tag: CWI26_RS05990
• Protein ID: WP_024415699.1
• Coordinates: 1209627..1210103 (-)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CWI26_RS05960	1204498..1204863	-	366	WP_024380649.1	MobC family plasmid mobilization relaxosome protein	-
CWI26_RS05965	1204873..1205232	-	360	WP_024380648.1	hypothetical protein	-
CWI26_RS05970	1205604..1206224	-	621	WP_024418307.1	TIR domain-containing protein	-
CWI26_RS05975	1206224..1207633	-	1410	WP_024418308.1	SIR2 family protein	-
CWI26_RS05980	1207663..1208823	-	1161	WP_024418309.1	toll/interleukin-1 receptor domain-containing protein	-
CWI26_RS05985	1208842..1209627	-	786	WP_100881383.1	zeta toxin family protein	Toxin
CWI26_RS05990	1209627..1210103	-	477	WP_024415699.1	helix-turn-helix domain-containing protein	Antitoxin
CWI26_RS05995	1210173..1210463	-	291	WP_000667953.1	hypothetical protein	-
CWI26_RS06000	1210513..1210902	-	390	WP_002935071.1	hypothetical protein	-
CWI26_RS06005	1210899..1211126	-	228	WP_002935073.1	hypothetical protein	-
CWI26_RS06010	1211180..1212256	-	1077	WP_024378757.1	toprim domain-containing protein	-
CWI26_RS06015	1212296..1212934	-	639	WP_024378756.1	hypothetical protein	-
CWI26_RS06020	1213067..1213335	+	269	Protein_1101	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	tet(O) / erm(B)	-	1195416..1291622	96206

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (28-215)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 262 a.a.
• Molecular weight: 29862.80 Da
• Isoelectric Point: 5.7033

>T89584 WP_100881383.1 NZ_CP025043:c1209627-1208842 [Streptococcus suis]
MRLEEFSEVEFQKALQRTIRALTRGKTIPDQPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEHLVDELSKRGYHLLIEGTLRTTQVPRQTAQLLTSKGYQVSLAIIGTKPELSYLSTLIRYEE
LYAIDPTQARATPKDHHDGIVENLVDNLRELESDKIFDRIQIYQRDRTCIYDSETDDGSAAEVLQNCLFGDWSKVEEEMM
KVGRERLQELIEDNILQNNIK

Nucleotide

• Length: 786 bp

>T89584 NZ_CP025043:c1209627-1208842 [Streptococcus suis]
ATGAGATTGGAAGAATTTAGTGAGGTAGAGTTTCAGAAGGCCTTACAGCGAACCATTCGGGCTTTAACTCGAGGAAAGAC
GATTCCAGATCAACCGAAAGCCATTTTACTTGGAGGTCAGAGCGGAGCAGGTAAGACAACGATACATCGTATCAAGCAAA
AAGAATTTCAAGGCAATATCATTATCATCGATGGTGACAGCTACCGTTCTCAGCATCCCAATTACTTAGCCTTGCAAGAA
AAGTATGGCAAAGATAGCGTGGACTATACCAAGGGATTTGCAGGAAAGATGGTAGAACATCTGGTTGATGAACTCAGTAA
ACGTGGTTATCATTTGTTAATTGAAGGGACTTTGCGTACCACTCAAGTTCCTCGTCAGACTGCTCAATTATTAACTTCTA
AAGGTTACCAAGTTTCTTTAGCTATTATTGGTACCAAACCAGAACTGTCCTATCTCAGCACCTTGATTCGTTACGAAGAG
CTTTATGCCATCGATCCGACGCAGGCCAGAGCAACACCCAAAGACCACCATGATGGGATTGTAGAGAACTTGGTTGATAA
CCTAAGAGAGTTAGAAAGCGATAAGATCTTTGACCGCATTCAGATTTATCAAAGAGACAGGACTTGCATTTATGATTCTG
AAACTGATGATGGTTCAGCAGCAGAAGTTCTTCAAAACTGCCTTTTCGGAGATTGGAGTAAAGTAGAGGAAGAAATGATG
AAGGTTGGACGGGAACGATTACAGGAGTTAATTGAGGACAATATACTGCAAAATAATATTAAGTAG

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18243.69 Da
• Isoelectric Point: 4.4582

>AT89584 WP_024415699.1 NZ_CP025043:c1210103-1209627 [Streptococcus suis]
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYQLTLKIE
VIKERGAAILSQLYRYQDSQGIAFDDETNPWILMSDDLAELINTKIYLVDTFDEIERYNGYLDGIERMLDMVHHRVVA

Nucleotide

• Length: 477 bp

>AT89584 NZ_CP025043:c1210103-1209627 [Streptococcus suis]
ATGATTGGAGACAATATTAAATCACTACGCCGAACACACGATTTAACACAACCAGAATTTGCGAAAATGGTCGGGATTTC
ACGCAATAGCCTGAGTCGCTACGAAAATGGAACCAGCACCGTTTCAACAGAACTCATTGACCGCATTTGTCAGAAATTTA
ACGTTTCTTATGTCGATATTGTAGGAGAGGACAAGATGCTAACACCTGTTGAAGATTACCAACTGACTTTAAAAATAGAA
GTGATAAAAGAACGTGGAGCAGCCATTTTATCTCAACTCTATCGATATCAGGATAGTCAAGGTATTGCTTTTGATGATGA
AACAAATCCTTGGATTTTGATGAGTGATGATTTGGCTGAATTGATCAATACGAAAATATACCTTGTCGATACTTTCGATG
AAATAGAGCGTTACAATGGCTATTTAGACGGTATCGAGCGGATGTTAGACATGGTGCATCATCGGGTGGTGGCTTAA

Structures

Antitoxin

• AlphaFold DB: A0A0Z8GXZ9