89583

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1183655..1184156 Replicon chromosome
Accession NZ_CP025043
Organism Streptococcus suis strain AH681

Toxin (Protein)


Gene name relE Uniprot ID A0A0M9FF45
Locus tag CWI26_RS05850 Protein ID WP_024405694.1
Coordinates 1183655..1183921 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0M9FEY8
Locus tag CWI26_RS05855 Protein ID WP_029176726.1
Coordinates 1183905..1184156 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CWI26_RS05830 1179291..1180361 + 1071 WP_100881375.1 tyrosine recombinase XerS -
CWI26_RS05835 1180425..1181933 - 1509 WP_100881376.1 phosphomannomutase/phosphoglucomutase -
CWI26_RS05840 1182010..1182951 - 942 WP_100881377.1 sensor histidine kinase -
CWI26_RS05845 1182948..1183613 - 666 WP_029176725.1 response regulator transcription factor -
CWI26_RS05850 1183655..1183921 - 267 WP_024405694.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CWI26_RS05855 1183905..1184156 - 252 WP_029176726.1 hypothetical protein Antitoxin
CWI26_RS05860 1184248..1186218 - 1971 WP_100881378.1 FtsX-like permease family protein -
CWI26_RS05865 1186219..1186971 - 753 WP_100881379.1 ABC transporter ATP-binding protein -
CWI26_RS05870 1186980..1187375 - 396 WP_100881380.1 NisI/SpaI family lantibiotic immunity lipoprotein -
CWI26_RS05875 1187388..1187528 - 141 WP_032499492.1 hypothetical protein -
CWI26_RS05880 1187933..1189099 - 1167 WP_032510490.1 ATP-grasp domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-87)

Antitoxin

Protein of unknown function DUF6290

(1-75)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10392.08 Da        Isoelectric Point: 10.6122

>T89583 WP_024405694.1 NZ_CP025043:c1183921-1183655 [Streptococcus suis]
MKTCYKLVPTSRFIKQLKKLDKFTQKQITNYLSSHVTDNPRQYGKALTANRSGQWRYRIGNYRVIVSIEDDKLIVTALEV
GHRKEIYK

Download         Length: 267 bp

>T89583 NZ_CP025043:c1183921-1183655 [Streptococcus suis]
ATGAAGACCTGCTATAAACTCGTACCAACCAGTCGTTTTATCAAACAGTTGAAAAAGTTGGACAAATTTACCCAAAAACA
GATTACCAACTACCTGTCCAGTCATGTGACTGACAACCCCAGACAATACGGAAAAGCCTTAACGGCCAATCGTTCTGGCC
AATGGCGATACCGTATCGGCAATTATAGGGTTATCGTCAGCATTGAAGATGATAAATTGATTGTGACAGCCCTTGAAGTC
GGGCATCGGAAAGAAATATATAAATAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9447.68 Da        Isoelectric Point: 3.8049

>AT89583 WP_029176726.1 NZ_CP025043:c1184156-1183905 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADIAWAEYQEDLANGIEPISWEEMLEELGLTHE
DLL

Download         Length: 252 bp

>AT89583 NZ_CP025043:c1184156-1183905 [Streptococcus suis]
ATGGCAGCTATTACATTGAAAGTTTCTGAGCAGGACAAACTCTTTATGCAGGCTATGGCAAAGTTTGAAGGTGTGAGTTT
GTCAGAACTCATTCGGACTAAAACCCTTGAAGCACTTGAAGATGAGTACGATGCCCGTGTGGCAGACATTGCTTGGGCAG
AATACCAAGAAGACTTGGCGAATGGCATTGAGCCGATCAGCTGGGAGGAAATGTTGGAAGAGTTGGGGTTGACGCATGAA
GACCTGCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M9FF45

Antitoxin

Source ID Structure
AlphaFold DB A0A0M9FEY8

References