Detailed information of TA system TA089551

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2448954..2449558
• Replicon: chromosome
• Accession: NZ_CP025034
• Organism: Enterobacter sp. SGAir0187

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: CWR52_RS11740
• Protein ID: WP_104949731.1
• Coordinates: 2449373..2449558 (-)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: CWR52_RS11735
• Protein ID: WP_104949730.1
• Coordinates: 2448954..2449358 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CWR52_RS11720	2444503..2445312	-	810	WP_104949727.1	helix-turn-helix domain-containing protein	-
CWR52_RS11725	2445538..2446938	+	1401	WP_104949728.1	MFS transporter	-
CWR52_RS11730	2446949..2448898	+	1950	WP_104949729.1	glycoside hydrolase family 127 protein	-
CWR52_RS11735	2448954..2449358	-	405	WP_104949730.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
CWR52_RS11740	2449373..2449558	-	186	WP_104949731.1	type II toxin-antitoxin system HicA family toxin	Toxin
CWR52_RS11745	2449768..2450508	-	741	WP_104949732.1	MipA/OmpV family protein	-
CWR52_RS11750	2450626..2451591	+	966	WP_104949733.1	LysR family transcriptional regulator	-
CWR52_RS11755	2451588..2453126	-	1539	WP_104949734.1	aldehyde dehydrogenase AldB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-129)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 6839.98 Da
• Isoelectric Point: 11.2341

>T89551 WP_104949731.1 NZ_CP025034:c2449558-2449373 [Enterobacter sp. SGAir0187]
VKSADVITVLTGHGWKCVRTKGSHHQFRHPEQKGLVTVPHPKKDIKPGTLAQIWRQAGIKH

Nucleotide

• Length: 186 bp

>T89551 NZ_CP025034:c2449558-2449373 [Enterobacter sp. SGAir0187]
GTGAAAAGTGCGGATGTCATTACTGTTCTGACCGGCCATGGCTGGAAATGTGTCAGAACGAAAGGAAGCCATCATCAGTT
TCGCCATCCCGAACAGAAAGGGCTGGTTACTGTCCCACATCCTAAGAAGGATATTAAACCGGGCACTCTCGCCCAGATTT
GGCGACAGGCGGGAATTAAACACTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14944.67 Da
• Isoelectric Point: 4.3197

>AT89551 WP_104949730.1 NZ_CP025034:c2449358-2448954 [Enterobacter sp. SGAir0187]
MFYPAYIHSDSDGSASGFFPDVPGCFFAGDSLDDAFQDARDALTAHFEALFEMDDALPLSGNVEAHLESRPEDFTGGQWL
LVDINMKQFDGRAERINITMPRRLLVKIDSFVSEHPQFGNRSAFLAEAARRVLP

Nucleotide

• Length: 405 bp

>AT89551 NZ_CP025034:c2449358-2448954 [Enterobacter sp. SGAir0187]
ATGTTTTATCCGGCTTATATACATTCTGACTCCGACGGTAGCGCCAGCGGCTTTTTCCCTGACGTTCCAGGCTGTTTTTT
TGCAGGTGATTCCCTGGACGACGCTTTTCAGGATGCACGTGATGCGCTAACAGCGCACTTCGAAGCGCTGTTTGAAATGG
ATGATGCACTGCCTCTTTCGGGGAATGTGGAAGCGCATCTGGAAAGTCGTCCTGAGGATTTCACTGGCGGGCAATGGCTG
TTGGTGGATATTAATATGAAGCAGTTCGACGGGAGGGCCGAGCGTATCAACATCACGATGCCTCGACGTTTGCTGGTAAA
GATTGATTCCTTTGTCAGCGAGCATCCTCAGTTCGGTAATCGAAGCGCATTTCTGGCCGAGGCAGCACGTCGCGTGCTGC
CATAG