Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1451389..1452009 Replicon chromosome
Accession NZ_CP025034
Organism Enterobacter sp. SGAir0187

Toxin (Protein)


Gene name Hha Uniprot ID A0A1H8SI38
Locus tag CWR52_RS07025 Protein ID WP_008499287.1
Coordinates 1451791..1452009 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V3PBI9
Locus tag CWR52_RS07020 Protein ID WP_008499288.1
Coordinates 1451389..1451763 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CWR52_RS07010 1446519..1447712 + 1194 WP_045909753.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
CWR52_RS07015 1447735..1450881 + 3147 WP_104949244.1 multidrug efflux RND transporter permease subunit AcrB -
CWR52_RS07020 1451389..1451763 + 375 WP_008499288.1 Hha toxicity modulator TomB Antitoxin
CWR52_RS07025 1451791..1452009 + 219 WP_008499287.1 hemolysin expression modulator Hha Toxin
CWR52_RS07030 1452218..1452769 + 552 WP_045909755.1 maltose O-acetyltransferase -
CWR52_RS07035 1452887..1453354 + 468 WP_104949245.1 hypothetical protein -
CWR52_RS07040 1453326..1454786 - 1461 WP_104949246.1 PLP-dependent aminotransferase family protein -
CWR52_RS07045 1454888..1455598 + 711 WP_069720245.1 GNAT family N-acetyltransferase -
CWR52_RS07050 1455595..1455735 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
CWR52_RS07055 1455738..1455998 - 261 WP_006176933.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8612.00 Da        Isoelectric Point: 8.9008

>T89550 WP_008499287.1 NZ_CP025034:1451791-1452009 [Enterobacter sp. SGAir0187]
MSDKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

>T89550 NZ_CP025034:1451791-1452009 [Enterobacter sp. SGAir0187]
ATGTCTGATAAACCACTCACAAAAATCGATTATTTGATGCGCTTACGACGTTGCCAGTCAATTGACACGCTCGAACGCGT
CATTGAAAAGAATAAATACGAGCTTTCTGATAATGAACTGGCCGTATTTTATTCAGCCGCGGACCATCGTCTTGCTGAAC
TGACCATGAATAAGCTGTATGACAAAATCCCTACTTCTGTATGGAAATTTGTCCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14481.28 Da        Isoelectric Point: 4.8886

>AT89550 WP_008499288.1 NZ_CP025034:1451389-1451763 [Enterobacter sp. SGAir0187]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp

>AT89550 NZ_CP025034:1451389-1451763 [Enterobacter sp. SGAir0187]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAACCTTGATGAAAGTAACCATGGCTGGGTAAACGACCCAACGTCTGCCATCAATTTACAGTTGAATGAGCTGATAGAGC
ATATCGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGCTCATTGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGTAGTTACGGCATTAACGCCCAGGATTTGCAAAAATGGCGTAAATCGGGAAACCGGCT
ATTCCGCTGTTTCGTCAACGTGAGCAGAGCTAACCCGGTTAGTCTTTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8SI38

Antitoxin

Source ID Structure
AlphaFold DB V3PBI9

References