89547

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2610465..2610997 Replicon chromosome
Accession NZ_CP025031
Organism Staphylococcus haemolyticus strain SGAir0252

Toxin (Protein)


Gene name mazF Uniprot ID Q4L7V3
Locus tag CWR44_RS12865 Protein ID WP_011275272.1
Coordinates 2610465..2610830 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q4L7V4
Locus tag CWR44_RS12870 Protein ID WP_011275271.1
Coordinates 2610827..2610997 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CWR44_RS12845 2607505..2608275 - 771 WP_011275276.1 RNA polymerase sigma factor SigB -
CWR44_RS12850 2608250..2608729 - 480 WP_011275275.1 anti-sigma B factor RsbW -
CWR44_RS12855 2608731..2609057 - 327 WP_011275274.1 anti-sigma factor antagonist -
CWR44_RS12860 2609156..2610157 - 1002 WP_011275273.1 PP2C family protein-serine/threonine phosphatase -
CWR44_RS12865 2610465..2610830 - 366 WP_011275272.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
CWR44_RS12870 2610827..2610997 - 171 WP_011275271.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
CWR44_RS12875 2611083..2612231 - 1149 WP_016931365.1 alanine racemase -
CWR44_RS12880 2612327..2612686 - 360 WP_011275269.1 holo-ACP synthase -
CWR44_RS12885 2612696..2613223 - 528 WP_016931364.1 PH domain-containing protein -
CWR44_RS12890 2613216..2614739 - 1524 WP_016931363.1 PH domain-containing protein -
CWR44_RS12895 2614732..2615211 - 480 WP_011275266.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13672.75 Da        Isoelectric Point: 8.4121

>T89547 WP_011275272.1 NZ_CP025031:c2610830-2610465 [Staphylococcus haemolyticus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYRLDKDSVILLEQIR
TLDKKRLKEKLTYLSDEKMQEVDEALDISLGLHDEVKTQNT

Download         Length: 366 bp

>T89547 NZ_CP025031:c2610830-2610465 [Staphylococcus haemolyticus]
ATGATTAGAAGAGGCGATGTATATTTAGCTGATTTGTCACCAGTACAGGGCTCAGAACAAGGGGGAGTCAGACCTGTAGT
TATCATTCAAAACGATACTGGTAACAAATATAGTCCTACCGTAATCGTTGCTGCGATTACGGGAAGGATTAATAAAGCGA
AAATACCCACACATGTTGAAATCGAGAAAAAGAAATACAGACTTGATAAAGATTCAGTTATTCTACTCGAGCAAATTAGA
ACATTAGATAAAAAACGACTAAAAGAAAAATTAACATATCTATCTGATGAGAAAATGCAAGAAGTGGATGAAGCGTTAGA
CATTAGTCTAGGATTGCATGATGAAGTTAAAACGCAAAACACATAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6380.08 Da        Isoelectric Point: 4.0325

>AT89547 WP_011275271.1 NZ_CP025031:c2610997-2610827 [Staphylococcus haemolyticus]
MLTFNQNRSHSLEQSLKEGYAQMAELNLSLATEAFPLECEACDCNETYLISNYKSE

Download         Length: 171 bp

>AT89547 NZ_CP025031:c2610997-2610827 [Staphylococcus haemolyticus]
ATGCTTACTTTCAATCAAAATAGAAGTCACAGTCTTGAACAATCTTTAAAAGAAGGCTATGCACAAATGGCCGAATTAAA
TCTCTCCCTAGCGACAGAAGCTTTTCCTCTAGAATGCGAAGCTTGTGATTGCAACGAAACGTACCTTATTTCTAATTATA
AAAGTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A1KA75

Antitoxin

Source ID Structure
AlphaFold DB A0A2A1K7K7

References