Detailed information of TA system TA089541

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsdAT/-
• Location: 11555..12066
• Replicon: chromosome
• Accession: NZ_CP025031
• Organism: Staphylococcus haemolyticus strain SGAir0252

Toxin (Protein)

• Gene name: TsdT
• Uniprot ID: Q4L7W7
• Locus tag: CWR44_RS00060
• Protein ID: WP_011275259.1
• Coordinates: 11555..11761 (-)
• Length: 69 a.a.

Antitoxin (Protein)

• Gene name: TsdA
• Uniprot ID: -
• Locus tag: CWR44_RS00065
• Protein ID: WP_011275258.1
• Coordinates: 11773..12066 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CWR44_RS00040	6674..7744	-	1071	WP_048668181.1	D-alanine--D-alanine ligase	-
CWR44_RS00045	8162..9361	+	1200	WP_048668183.1	rod shape-determining protein RodA	-
CWR44_RS00050	9617..11305	+	1689	WP_104948179.1	IS1182 family transposase	-
CWR44_RS00055	11310..11447	-	138	WP_011275260.1	hypothetical protein	-
CWR44_RS00060	11555..11761	-	207	WP_011275259.1	heavy-metal-associated domain-containing protein	Toxin
CWR44_RS00065	11773..12066	-	294	WP_011275258.1	copper-sensing transcriptional repressor CsoR	Antitoxin
CWR44_RS00070	12253..13737	+	1485	WP_016931421.1	cardiolipin synthase	-
CWR44_RS00075	13837..14478	+	642	WP_016931420.1	HD domain-containing protein	-
CWR44_RS00080	14527..15843	-	1317	WP_104948180.1	ISL3 family transposase	-
CWR44_RS00085	16038..16913	-	876	WP_011275255.1	membrane protein insertase YidC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	IScluster/Tn	-	-	9617..15843	6226

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Metal-sensitive transcriptional repressor (3-95)

Sequences

Toxin

Protein

• Length: 69 a.a.
• Molecular weight: 7857.79 Da
• Isoelectric Point: 4.0742

>T89541 WP_011275259.1 NZ_CP025031:c11761-11555 [Staphylococcus haemolyticus]
MNFSEIRISELNTEEQANSLQHRLEKMIGVDEVIVELNDQLVKISYETPTNLNSIEKEIYDDGYKVLG

Nucleotide

• Length: 207 bp

>T89541 NZ_CP025031:c11761-11555 [Staphylococcus haemolyticus]
ATGAACTTTAGTGAAATTAGAATTAGTGAATTAAATACTGAAGAGCAAGCTAATTCACTCCAACATAGACTTGAGAAGAT
GATAGGTGTAGATGAAGTAATTGTAGAACTAAATGACCAATTAGTTAAAATTTCTTATGAAACACCTACGAATTTAAATA
GTATTGAAAAAGAAATTTATGATGATGGTTATAAGGTATTAGGTTGA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11222.83 Da
• Isoelectric Point: 6.6361

>AT89541 WP_011275258.1 NZ_CP025031:c12066-11773 [Staphylococcus haemolyticus]
MNNHENAHHSDQIKMNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLDHHMKSCIMDKVNNGAQ
EEAMEELLVTFQKLMKD

Nucleotide

• Length: 294 bp

>AT89541 NZ_CP025031:c12066-11773 [Staphylococcus haemolyticus]
TTGAATAATCATGAAAATGCACATCATTCCGATCAAATTAAAATGAATTTAAAATCAAGACTTAATCGTATTGAAGGGCA
AGTTAGAGCGATTAATCGCATGATTGAAGAAGATGTATACTGTGATGACGTGCTAACTCAAATTAGAGCTACAAGATCAG
CTTTAAATAGTGTGGCCACTAAGTTGCTAGATCATCATATGAAAAGCTGTATCATGGATAAAGTGAATAACGGCGCTCAA
GAAGAAGCGATGGAAGAATTGTTAGTGACTTTTCAAAAATTAATGAAAGATTAG

Structures

Toxin

• AlphaFold DB: A0A2A1K7I8