Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 6364622..6365246 Replicon chromosome
Accession NZ_CP025030
Organism Achromobacter spanius strain DSM 23806

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag CVS48_RS28870 Protein ID WP_100857904.1
Coordinates 6364622..6364804 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag CVS48_RS28875 Protein ID WP_100857414.1
Coordinates 6364854..6365246 (+) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CVS48_RS28840 6360419..6361288 - 870 WP_100857409.1 hydrolase -
CVS48_RS28845 6361562..6362479 - 918 WP_100857410.1 DUF808 domain-containing protein -
CVS48_RS28850 6362672..6362929 - 258 WP_100857411.1 hypothetical protein -
CVS48_RS28855 6362984..6363187 - 204 WP_050448526.1 cold-shock protein -
CVS48_RS28860 6363655..6364092 + 438 WP_100857412.1 hypothetical protein -
CVS48_RS28865 6364112..6364453 - 342 WP_100857413.1 hypothetical protein -
CVS48_RS28870 6364622..6364804 + 183 WP_100857904.1 type II toxin-antitoxin system HicA family toxin Toxin
CVS48_RS28875 6364854..6365246 + 393 WP_100857414.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CVS48_RS28880 6365288..6366028 - 741 WP_100857415.1 SDR family oxidoreductase -
CVS48_RS28885 6366066..6367406 - 1341 WP_100857416.1 CitMHS family transporter -
CVS48_RS28890 6367597..6368301 + 705 WP_100857417.1 response regulator transcription factor -
CVS48_RS28895 6368305..6369747 + 1443 WP_100857418.1 sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6739.95 Da        Isoelectric Point: 12.1585

>T89540 WP_100857904.1 NZ_CP025030:6364622-6364804 [Achromobacter spanius]
MNSREIIRQLRQAGWVFRHAKGSHHIFVHPQKAGHISVPHPKKDLGIGLVTKLLTQAGLK

Download         Length: 183 bp

>T89540 NZ_CP025030:6364622-6364804 [Achromobacter spanius]
ATGAACAGCCGCGAGATCATCAGACAGCTTCGCCAAGCGGGCTGGGTATTCCGACATGCGAAAGGCTCGCATCACATTTT
CGTCCACCCGCAAAAAGCTGGGCATATCAGCGTGCCTCACCCCAAGAAAGACTTGGGGATCGGACTGGTTACGAAACTGC
TGACGCAAGCCGGCCTGAAGTAG

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 13901.74 Da        Isoelectric Point: 4.2687

>AT89540 WP_100857414.1 NZ_CP025030:6364854-6365246 [Achromobacter spanius]
MKYPIAIEPGSETQAWGVVVPDLPGCFSAADSGIDEAIENAKEAIELWIETALDSGTPVPVATSIAGHQANPEFAGWVWA
IVEIDPAVMDDTIERINITLPRRILARIDAKARAAGESRSGYIAHLALTH

Download         Length: 393 bp

>AT89540 NZ_CP025030:6364854-6365246 [Achromobacter spanius]
ATGAAATATCCAATCGCCATTGAACCCGGCAGCGAGACGCAAGCGTGGGGCGTCGTCGTGCCGGATCTGCCGGGCTGCTT
TTCCGCCGCCGACTCAGGCATAGACGAAGCTATCGAGAACGCAAAAGAAGCGATCGAGCTGTGGATTGAAACCGCGTTGG
ATAGCGGCACACCCGTACCCGTTGCCACCAGCATTGCGGGTCACCAAGCGAATCCGGAATTCGCGGGCTGGGTTTGGGCC
ATTGTTGAAATCGATCCGGCCGTCATGGACGACACCATCGAACGCATCAACATCACGCTGCCCCGCCGAATCCTTGCAAG
GATCGACGCCAAAGCGCGTGCGGCGGGAGAAAGCCGATCTGGCTACATCGCTCATCTGGCATTGACGCACTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References