Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 4530092..4530774 Replicon chromosome
Accession NZ_CP025030
Organism Achromobacter spanius strain DSM 23806

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CVS48_RS20435 Protein ID WP_100856032.1
Coordinates 4530340..4530774 (+) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag CVS48_RS20430 Protein ID WP_100856031.1
Coordinates 4530092..4530343 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CVS48_RS20410 4525481..4527295 - 1815 WP_100856027.1 NYN domain-containing protein -
CVS48_RS20415 4527594..4528499 + 906 WP_100856028.1 MotA/TolQ/ExbB proton channel family protein -
CVS48_RS20420 4528496..4529473 + 978 WP_100856029.1 OmpA family protein -
CVS48_RS20425 4529639..4529992 + 354 WP_100856030.1 dehydrogenase -
CVS48_RS20430 4530092..4530343 + 252 WP_100856031.1 Arc family DNA-binding protein Antitoxin
CVS48_RS20435 4530340..4530774 + 435 WP_100856032.1 type II toxin-antitoxin system VapC family toxin Toxin
CVS48_RS20440 4530898..4531308 + 411 WP_100856033.1 YciI family protein -
CVS48_RS20445 4531327..4531734 + 408 WP_100856034.1 VOC family protein -
CVS48_RS20450 4531731..4533005 + 1275 WP_100856035.1 RNA polymerase sigma factor -
CVS48_RS20455 4533149..4533973 + 825 WP_100857775.1 AraC family transcriptional regulator -
CVS48_RS20460 4534108..4535097 + 990 WP_100856036.1 DMT family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

Arc-like DNA binding domain

(10-46)


Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15218.44 Da        Isoelectric Point: 5.5556

>T89539 WP_100856032.1 NZ_CP025030:4530340-4530774 [Achromobacter spanius]
MILLDTNVISEPLRQAPADAVIEWIDRQPLETLFLSAVTVAELRFGVACMPVGKRRDALHGDLEQRVLALFAGRVLAFDT
AASLEYATLMARARASGQSIGGPDGYIAATAAAHGMSVATRDIAPFEAAGVSVINPWGASHPPH

Download         Length: 435 bp

>T89539 NZ_CP025030:4530340-4530774 [Achromobacter spanius]
ATGATTCTGCTGGACACCAATGTCATTTCGGAACCGCTGCGCCAAGCGCCCGCCGACGCCGTCATCGAATGGATAGACCG
GCAGCCCTTGGAAACCCTGTTCCTTTCCGCCGTCACCGTCGCTGAATTGCGGTTTGGCGTCGCCTGCATGCCAGTGGGCA
AACGGCGCGACGCCTTGCATGGCGACCTGGAACAGCGCGTGCTGGCCTTGTTTGCCGGGCGCGTCCTGGCTTTCGACACC
GCCGCCAGCCTGGAATACGCCACGTTGATGGCGCGCGCGCGGGCTTCGGGCCAGTCCATCGGCGGGCCAGACGGCTACAT
CGCCGCCACCGCCGCCGCGCACGGCATGAGCGTGGCCACCCGGGACATTGCGCCCTTTGAAGCCGCGGGCGTTTCCGTCA
TCAACCCTTGGGGCGCCTCGCACCCGCCGCACTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9228.57 Da        Isoelectric Point: 8.8737

>AT89539 WP_100856031.1 NZ_CP025030:4530092-4530343 [Achromobacter spanius]
MPMLTVRNISEEVHRALRVRAAQHGRSTEAEVRAILEDAVKPEGRVKLGSLLAQIGRQAKLTEEEAALFDQRDKAPAAPP
RFE

Download         Length: 252 bp

>AT89539 NZ_CP025030:4530092-4530343 [Achromobacter spanius]
ATGCCCATGTTGACCGTTAGAAATATCTCTGAAGAAGTGCACCGCGCGCTGCGCGTGCGCGCCGCCCAGCATGGCCGAAG
CACCGAAGCCGAGGTCCGCGCCATTCTTGAAGACGCCGTCAAGCCTGAAGGGCGCGTCAAGCTGGGCTCGTTGCTTGCGC
AGATCGGCCGCCAGGCCAAGCTCACCGAAGAGGAAGCCGCCTTGTTCGACCAACGCGACAAGGCGCCCGCCGCCCCACCG
AGGTTTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References