Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 3463108..3463774 Replicon chromosome
Accession NZ_CP025030
Organism Achromobacter spanius strain DSM 23806

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CVS48_RS15795 Protein ID WP_100857686.1
Coordinates 3463328..3463774 (+) Length 149 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag CVS48_RS15790 Protein ID WP_100855259.1
Coordinates 3463108..3463344 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CVS48_RS15765 3459422..3459739 - 318 WP_100855254.1 chaperone NapD -
CVS48_RS15770 3459763..3459921 - 159 WP_100855255.1 periplasmic nitrate reductase, NapE protein -
CVS48_RS15775 3460163..3461017 - 855 WP_100855256.1 3-keto-5-aminohexanoate cleavage protein -
CVS48_RS15780 3461014..3461976 - 963 WP_100855257.1 NAD-binding protein -
CVS48_RS15785 3462100..3463008 + 909 WP_100855258.1 LysR family transcriptional regulator -
CVS48_RS15790 3463108..3463344 + 237 WP_100855259.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
CVS48_RS15795 3463328..3463774 + 447 WP_100857686.1 PIN domain-containing protein Toxin
CVS48_RS15800 3463845..3464528 - 684 WP_167401006.1 GntR family transcriptional regulator -
CVS48_RS15805 3464550..3466325 - 1776 WP_167401007.1 dihydroxy-acid dehydratase -
CVS48_RS15810 3466548..3467543 + 996 WP_100855260.1 tripartite tricarboxylate transporter substrate binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-119)

Antitoxin

SpoVT-AbrB domain

(5-44)


Sequences

Toxin        


Download         Length: 149 a.a.        Molecular weight: 16903.63 Da        Isoelectric Point: 5.2332

>T89537 WP_100857686.1 NZ_CP025030:3463328-3463774 [Achromobacter spanius]
IAVISDARVFLDSNILIYLLSADARRADIAEVLLKGKPFISVQVLNEVTNVCVRKLKRQWEETNEFLAMVRMFCRVVPLT
VDVHDKARQLAERYQMSFYDACIAASALAVDCQILYTEDMQADMSIDQRLTLINPFTQQRSRLAEPGF

Download         Length: 447 bp

>T89537 NZ_CP025030:3463328-3463774 [Achromobacter spanius]
ATCGCCGTGATAAGTGACGCGCGCGTTTTTCTTGATAGCAACATCCTGATCTATCTGCTGAGCGCCGATGCACGCCGGGC
CGACATTGCTGAAGTCCTGCTCAAAGGCAAGCCATTCATCAGCGTCCAGGTGCTGAATGAGGTAACGAATGTCTGCGTGC
GCAAGCTGAAAAGACAGTGGGAAGAGACTAACGAGTTTCTGGCAATGGTCAGGATGTTCTGTCGTGTTGTGCCACTGACT
GTTGACGTCCACGACAAGGCGCGTCAATTGGCTGAACGCTATCAAATGTCGTTCTATGACGCTTGCATCGCGGCATCGGC
GTTGGCCGTCGACTGCCAGATTCTCTACACGGAAGACATGCAGGCCGATATGTCGATTGATCAGCGGCTCACGCTTATCA
ACCCGTTTACGCAACAGCGTTCGCGCTTGGCTGAGCCGGGTTTTTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8875.07 Da        Isoelectric Point: 7.2053

>AT89537 WP_100855259.1 NZ_CP025030:3463108-3463344 [Achromobacter spanius]
MRVAKWGNSLAVRLPASVVDALNLQEGDDIEIHIQGDRHFEVRKTAGEEGVLAKLRQFRGMLPADFVFNRDEANRRDK

Download         Length: 237 bp

>AT89537 NZ_CP025030:3463108-3463344 [Achromobacter spanius]
ATGCGAGTCGCCAAGTGGGGAAATAGTCTGGCCGTGCGTCTTCCCGCCAGCGTGGTTGATGCGTTGAATCTGCAAGAGGG
CGACGATATCGAAATCCACATTCAGGGTGATCGTCATTTCGAAGTGCGCAAGACGGCCGGCGAGGAAGGGGTATTGGCGA
AGCTGCGTCAATTCCGCGGAATGTTGCCGGCAGACTTTGTTTTTAACCGTGACGAGGCGAATCGCCGTGATAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References