Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 2512865..2513406 Replicon chromosome
Accession NZ_CP025030
Organism Achromobacter spanius strain DSM 23806

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag CVS48_RS11455 Protein ID WP_100854560.1
Coordinates 2513131..2513406 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag CVS48_RS11450 Protein ID WP_100854559.1
Coordinates 2512865..2513131 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CVS48_RS11430 2508563..2508880 - 318 WP_100854555.1 NIPSNAP family protein -
CVS48_RS11435 2508917..2509909 - 993 WP_100854556.1 tripartite tricarboxylate transporter substrate binding protein -
CVS48_RS11440 2509994..2511679 - 1686 WP_100854557.1 thiamine pyrophosphate-binding protein -
CVS48_RS11445 2511808..2512707 - 900 WP_100854558.1 helix-turn-helix domain-containing protein -
CVS48_RS11450 2512865..2513131 + 267 WP_100854559.1 ribbon-helix-helix domain-containing protein Antitoxin
CVS48_RS11455 2513131..2513406 + 276 WP_100854560.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CVS48_RS11460 2513522..2514571 - 1050 WP_100854561.1 alpha/beta hydrolase -
CVS48_RS11465 2514867..2515493 + 627 WP_100854562.1 glutathione S-transferase family protein -
CVS48_RS11470 2515603..2516913 + 1311 WP_100854563.1 MHS family MFS transporter -
CVS48_RS11475 2516933..2517946 - 1014 WP_100854564.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(8-45)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10443.20 Da        Isoelectric Point: 9.6223

>T89536 WP_100854560.1 NZ_CP025030:2513131-2513406 [Achromobacter spanius]
MELKWTSKALSDLAPLYEFLAPANAPAAARAVQALVKAPGILLTHPRIGEQLFQFEPREVRKILVGQFEVRYEIQGSIIY
VLRLWHSREER

Download         Length: 276 bp

>T89536 NZ_CP025030:2513131-2513406 [Achromobacter spanius]
ATGGAACTGAAATGGACCAGCAAGGCGCTTTCCGATCTGGCGCCCTTGTATGAATTCCTGGCCCCGGCGAATGCGCCCGC
AGCCGCGCGCGCGGTCCAGGCGCTGGTAAAAGCGCCCGGCATATTGCTGACCCATCCCCGTATTGGCGAACAGCTATTCC
AGTTCGAACCGCGAGAGGTTCGAAAAATACTCGTCGGGCAGTTTGAGGTGCGCTACGAAATTCAGGGTTCGATCATCTAC
GTGTTGCGGCTGTGGCACAGCCGAGAGGAACGCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9779.24 Da        Isoelectric Point: 5.6939

>AT89536 WP_100854559.1 NZ_CP025030:2512865-2513131 [Achromobacter spanius]
MPVATKVLTAHVPLPLAEKVDQMAARLERSRGWIMKQALSAWIAQEEERDRLTQEALADVEAGRVVDHQAVQAWAESLGT
DKPLPVPR

Download         Length: 267 bp

>AT89536 NZ_CP025030:2512865-2513131 [Achromobacter spanius]
ATGCCCGTAGCCACCAAGGTGCTGACCGCACACGTGCCGCTCCCGCTGGCCGAGAAGGTAGATCAGATGGCTGCTCGTCT
TGAACGCTCGCGCGGCTGGATCATGAAGCAGGCGCTTTCCGCTTGGATCGCACAAGAGGAAGAACGCGATCGACTTACCC
AGGAAGCGCTGGCTGATGTCGAGGCCGGTCGCGTGGTTGACCACCAGGCCGTGCAAGCGTGGGCAGAAAGTCTGGGTACC
GACAAGCCGTTGCCGGTACCCCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References