Detailed information of TA system TA089535

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 1950222..1950795
• Replicon: chromosome
• Accession: NZ_CP025030
• Organism: Achromobacter spanius strain DSM 23806

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: CVS48_RS08890
• Protein ID: WP_100854122.1
• Coordinates: 1950508..1950795 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: CVS48_RS08885
• Protein ID: WP_100854121.1
• Coordinates: 1950222..1950521 (+)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CVS48_RS08865	1945671..1947329	+	1659	WP_100854117.1	amidohydrolase family protein	-
CVS48_RS08870	1947331..1948308	+	978	WP_100854118.1	GTP-binding protein	-
CVS48_RS08875	1948404..1949453	+	1050	WP_100854119.1	ABC transporter substrate-binding protein	-
CVS48_RS08880	1949519..1949998	-	480	WP_100854120.1	VOC family protein	-
CVS48_RS08885	1950222..1950521	+	300	WP_100854121.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
CVS48_RS08890	1950508..1950795	+	288	WP_100854122.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CVS48_RS08895	1950911..1953034	+	2124	WP_100854123.1	TonB-dependent receptor	-
CVS48_RS08900	1953258..1954028	+	771	WP_100854124.1	glucose 1-dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (3-52)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10864.61 Da
• Isoelectric Point: 9.5280

>T89535 WP_100854122.1 NZ_CP025030:1950508-1950795 [Achromobacter spanius]
VPVLEWRETAREDLLAIVDYISDDSPAAALRLVDEIQKKVVKLRERPRLYRAGRVAGTREMVIRPNYLVVYAESPRAVTI
LRVLHAAQQWPLDSA

Nucleotide

• Length: 288 bp

>T89535 NZ_CP025030:1950508-1950795 [Achromobacter spanius]
GTGCCGGTTCTTGAATGGCGCGAAACGGCTCGCGAGGATTTGCTGGCGATTGTCGATTACATCTCGGACGATAGCCCGGC
CGCGGCGCTGCGTTTGGTAGATGAAATTCAGAAGAAAGTGGTCAAGCTGCGTGAGCGCCCACGGCTGTATCGCGCGGGAC
GGGTAGCGGGCACCAGGGAAATGGTGATTCGGCCGAACTATTTGGTTGTGTATGCGGAATCGCCTCGCGCCGTGACAATT
TTGCGCGTCCTGCACGCCGCGCAGCAATGGCCGCTCGATAGCGCCTGA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 10636.34 Da
• Isoelectric Point: 10.1426

>AT89535 WP_100854121.1 NZ_CP025030:1950222-1950521 [Achromobacter spanius]
MAPTSMLHVRVDDKLKAEAAEKLANVGLTISDAVRILLTRVAKEGGLPAGLAVDALSYDSWFRAKVQEALADTRPPVAHE
AVMDEARALISKKKRRAGS

Nucleotide

• Length: 300 bp

>AT89535 NZ_CP025030:1950222-1950521 [Achromobacter spanius]
ATGGCACCCACTTCAATGTTGCACGTCCGTGTCGACGACAAGCTCAAGGCCGAAGCGGCGGAAAAGCTCGCCAACGTTGG
CCTGACCATCTCGGATGCGGTGCGAATTTTGCTGACAAGAGTGGCAAAAGAAGGCGGTTTGCCCGCCGGCTTGGCCGTCG
ACGCCTTGAGCTACGACTCTTGGTTTCGCGCGAAGGTGCAAGAGGCCTTGGCCGATACGCGGCCACCGGTCGCCCATGAA
GCGGTCATGGACGAGGCTCGTGCCCTGATCAGCAAGAAGAAGCGCCGTGCCGGTTCTTGA