89533

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 142187..143229 Replicon chromosome
Accession NZ_CP025030
Organism Achromobacter spanius strain DSM 23806

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag CVS48_RS00710 Protein ID WP_003109777.1
Coordinates 142654..143229 (+) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID I3TV68
Locus tag CVS48_RS00705 Protein ID WP_003050245.1
Coordinates 142187..142657 (+) Length 157 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CVS48_RS00670 137579..138997 - 1419 WP_020924934.1 TIGR03752 family integrating conjugative element protein -
CVS48_RS00675 138987..139898 - 912 WP_003105643.1 TIGR03749 family integrating conjugative element protein -
CVS48_RS00680 139895..140587 - 693 WP_003105641.1 TIGR03746 family integrating conjugative element protein -
CVS48_RS00685 140584..140982 - 399 WP_003105639.1 TIGR03750 family conjugal transfer protein -
CVS48_RS00690 140994..141353 - 360 WP_003090173.1 TIGR03745 family integrating conjugative element membrane protein -
CVS48_RS00695 141370..141603 - 234 WP_003050225.1 TIGR03758 family integrating conjugative element protein -
CVS48_RS00700 141600..141983 - 384 WP_003120001.1 RAQPRD family integrative conjugative element protein -
CVS48_RS00705 142187..142657 + 471 WP_003050245.1 helix-turn-helix domain-containing protein Antitoxin
CVS48_RS00710 142654..143229 + 576 WP_003109777.1 PIN domain-containing protein Toxin
CVS48_RS00715 143247..144161 + 915 WP_003105629.1 AAA family ATPase -
CVS48_RS00720 144158..144628 + 471 WP_003105626.1 hypothetical protein -
CVS48_RS00725 144625..145125 + 501 WP_003090159.1 hypothetical protein -
CVS48_RS00730 145125..146027 + 903 WP_003105624.1 nucleotidyltransferase domain-containing protein -
CVS48_RS00735 146066..146791 + 726 WP_003050273.1 CBASS effector endonuclease NucC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-114)

Antitoxin

Helix-turn-helix domain, group 17

(85-133)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21644.79 Da        Isoelectric Point: 5.6172

>T89533 WP_003109777.1 NZ_CP025030:142654-143229 [Achromobacter spanius]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPDDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIEVDRYLEILLRQGLVQTTKVLATYRTIL

Download         Length: 576 bp

>T89533 NZ_CP025030:142654-143229 [Achromobacter spanius]
ATGAGGCATTCCCCATTCACCGCCGTCTACGACGCGTGCGTTCTATATCCCGCGCCACTGCGGGATTTCCTGATGTGGCT
CGGCCTGTCTGGCCGCTTCCGGGCGCGGTGGAGCCAAGCCATTCATGAGGAGTGGAAACGCAACCTGTTGATCAACCGCC
CCGATCTCACCCGGGTTCAGGTCGACAGGACGTCGGATCTCATGGACCGGGCAATTCCGGACGGCTTGGTGGAGGGCTAC
GAAGCGCTCGTGGCAGGCCTGACATTGCCCGATCCGGACGACCGGCACGTCCTGGCTGCGGCGATTCGCTGCGGTGCGAG
CGTGATTGTGACGTTCAACGAACGGGATTTCCCGAACGATCTGCTGGCTCCGTACGGCATCGAATCGCAGCACCCCGATG
AGTTTGTGGACAACCTACTGGATCTGGACGCGGCCGCCGTGGTGTCGGCTGCGCAGCGCCAGCGTGCCCAACTCAAGCAT
CCGCCGATCGAGGTGGACCGCTATCTCGAAATCCTGCTGCGCCAGGGCCTTGTGCAAACGACCAAGGTGCTGGCGACCTA
TCGCACCATTCTCTGA

Antitoxin


Download         Length: 157 a.a.        Molecular weight: 17245.62 Da        Isoelectric Point: 6.3803

>AT89533 WP_003050245.1 NZ_CP025030:142187-142657 [Achromobacter spanius]
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE

Download         Length: 471 bp

>AT89533 NZ_CP025030:142187-142657 [Achromobacter spanius]
ATGACCACCGCCACTGCCCAATCCAAGATGACCCTTCCCGCCGCGGGAGAGGTGAAGGCAGCCGTCCAGGGTCAACGTGC
CTTGGCGGCTTACCTCGCAACCCAGTTCGAGACGCAGCACATCCAGATCTTTGATGACCACAAACAGGCTCATCAGGTGG
AACTGCCTACCTCGGCTTTACGCCTGCTGGTCGACATCCTGGCCGAGTTGGCCGATGGCAATGCAGTAAAGGTGGTGCCC
GTCCATGCAGAGCTGACGACCCAAGAGGCGGCGGACTTGCTCAACGTGTCCCGTCCCCATTTCGTCAAGCTGCTCGAAGA
TGGGGTGTTGGCATTTCATCGCACCGGCAAGCACCGCAGGGTGAGGTTCGCCGATCTGATGCAGTACAAGGAAGCGCGCG
AGCGCGCCAGTGAGCAGGCGATGGCCGAACTCGCTCAGCAGTCGCAAGAGTTGGGAATGGGATACGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB I3TV68

References