Detailed information of TA system TA089530

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 225150..225762
• Replicon: chromosome
• Accession: NZ_CP025027
• Organism: Streptococcus agalactiae strain SGEHI2015-107

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A8G2N8L3
• Locus tag: CWQ22_RS01375
• Protein ID: WP_000384860.1
• Coordinates: 225150..225485 (-)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q8E7D2
• Locus tag: CWQ22_RS01380
• Protein ID: WP_000259017.1
• Coordinates: 225475..225762 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CWQ22_RS01345	220348..220989	+	642	WP_000591144.1	hypothetical protein	-
CWQ22_RS01355	221289..222164	+	876	WP_000421240.1	hypothetical protein	-
CWQ22_RS01360	222200..222634	+	435	WP_100831568.1	hypothetical protein	-
CWQ22_RS01365	222951..224207	+	1257	WP_000122836.1	plasmid recombination protein	-
CWQ22_RS01370	224375..224845	+	471	WP_000130119.1	hypothetical protein	-
CWQ22_RS01375	225150..225485	-	336	WP_000384860.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CWQ22_RS01380	225475..225762	-	288	WP_000259017.1	hypothetical protein	Antitoxin
CWQ22_RS01385	226269..226559	+	291	WP_000078283.1	WXG100 family type VII secretion target	-
CWQ22_RS01390	226661..227029	+	369	WP_001882138.1	hypothetical protein	-
CWQ22_RS01395	227067..227627	+	561	WP_001865562.1	hypothetical protein	-
CWQ22_RS01400	227600..228280	+	681	WP_001865565.1	hypothetical protein	-
CWQ22_RS01405	228265..228651	+	387	WP_000259069.1	hypothetical protein	-
CWQ22_RS01410	228685..228966	+	282	WP_017647916.1	hypothetical protein	-
CWQ22_RS01430	229809..230669	+	861	WP_000477654.1	Rgg/GadR/MutR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	217181..226036	8855

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-106)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13227.87 Da
• Isoelectric Point: 4.5348

>T89530 WP_000384860.1 NZ_CP025027:c225485-225150 [Streptococcus agalactiae]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIINDIEKLEVFPEVGFDADEKYGSEISNYHSTRGYTLSKD
YIVLYHIEEEENSVVIDYLLPTRSDYMKLFK

Nucleotide

• Length: 336 bp

>T89530 NZ_CP025027:c225485-225150 [Streptococcus agalactiae]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCCCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAATGACATAGAAAAACTTGAAGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAGAAATCAGCAATTATCACAGTACTAGAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAAGAGGAAGAGAATAGCGTTGTCATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
GAAATTGTTTAAATAG

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10906.50 Da
• Isoelectric Point: 4.7271

>AT89530 WP_000259017.1 NZ_CP025027:c225762-225475 [Streptococcus agalactiae]
MVTVEKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEISKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT89530 NZ_CP025027:c225762-225475 [Streptococcus agalactiae]
ATGGTTACAGTAGAAAAAAATAGAGCTGTCACATTCCAAGCTAACAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCCGAAATCAGCAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Antitoxin

• AlphaFold DB: A0A076Z4V6