Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2079685..2080199 Replicon chromosome
Accession NZ_CP025023
Organism Staphylococcus argenteus strain XNO106

Toxin (Protein)


Gene name TsdT Uniprot ID A0A7U7JQI0
Locus tag CKO49_RS10170 Protein ID WP_000233591.1
Coordinates 2079685..2079894 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag CKO49_RS10175 Protein ID WP_000138932.1
Coordinates 2079906..2080199 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKO49_RS10150 2075020..2076384 - 1365 WP_031787694.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
CKO49_RS10155 2076399..2077469 - 1071 WP_031787695.1 D-alanine--D-alanine ligase -
CKO49_RS10160 2077788..2078990 + 1203 WP_031787696.1 rod shape-determining protein RodA -
CKO49_RS10165 2079419..2079556 - 138 WP_000828355.1 hypothetical protein -
CKO49_RS10170 2079685..2079894 - 210 WP_000233591.1 heavy-metal-associated domain-containing protein Toxin
CKO49_RS10175 2079906..2080199 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
CKO49_RS10180 2080367..2081851 + 1485 WP_031787697.1 cardiolipin synthase -
CKO49_RS10185 2081880..2082527 + 648 WP_072692834.1 HD domain-containing protein -
CKO49_RS10195 2083122..2083991 - 870 WP_000725805.1 membrane protein insertase YidC -
CKO49_RS10200 2084077..2084718 - 642 WP_031787699.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7827.81 Da        Isoelectric Point: 4.2681

>T89525 WP_000233591.1 NZ_CP025023:c2079894-2079685 [Staphylococcus argenteus]
MVHQNTIYTAGIETEEQVNQLTERISNMIGVHKVNINIIDGEVVVAYETPANLNSIEKEIYDTGYKIVY

Download         Length: 210 bp

>T89525 NZ_CP025023:c2079894-2079685 [Staphylococcus argenteus]
ATGGTACATCAAAACACAATATATACTGCAGGTATTGAAACTGAAGAACAAGTAAACCAGTTGACAGAACGTATATCAAA
CATGATAGGTGTGCATAAAGTGAATATTAATATCATTGATGGAGAAGTAGTTGTAGCATATGAAACACCCGCAAATTTAA
ATAGCATTGAAAAAGAAATTTATGATACAGGCTATAAAATTGTATATTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT89525 WP_000138932.1 NZ_CP025023:c2080199-2079906 [Staphylococcus argenteus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT89525 NZ_CP025023:c2080199-2079906 [Staphylococcus argenteus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATTAAAACAAATCTTAAATCACGTTTAAATCGAATAGAAGGTCA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTTCTTACACAAATAAGAGCGACGCGTTCTG
CATTAAACAGTGTCGCAATAAAGTTATTAGAGCAACATATGAAAAGTTGTATTATGAATAAAGTAAATCAAGGTGCTCAA
GAAGAAGCGATGGAAGAGTTACTAGTTACTTTTCAAAAGTTGATTAAAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7JQI0

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References