Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2059549..2060078 Replicon chromosome
Accession NZ_CP025023
Organism Staphylococcus argenteus strain XNO106

Toxin (Protein)


Gene name mazF Uniprot ID A0A7U7JQG1
Locus tag CKO49_RS10080 Protein ID WP_000621178.1
Coordinates 2059549..2059911 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag CKO49_RS10085 Protein ID WP_000948331.1
Coordinates 2059908..2060078 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKO49_RS10055 2056531..2057301 - 771 WP_001041104.1 RNA polymerase sigma factor SigB -
CKO49_RS10060 2057276..2057755 - 480 WP_001190826.1 anti-sigma B factor RsbW -
CKO49_RS10065 2057757..2058083 - 327 WP_001052491.1 anti-sigma factor antagonist -
CKO49_RS10070 2058200..2059201 - 1002 WP_000390825.1 PP2C family protein-serine/threonine phosphatase -
CKO49_RS10080 2059549..2059911 - 363 WP_000621178.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
CKO49_RS10085 2059908..2060078 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
CKO49_RS10090 2060163..2061311 - 1149 WP_001281137.1 alanine racemase -
CKO49_RS10095 2061381..2061740 - 360 WP_031787685.1 holo-ACP synthase -
CKO49_RS10100 2061744..2062247 - 504 WP_031787686.1 PH domain-containing protein -
CKO49_RS10105 2062234..2063817 - 1584 WP_031787687.1 PH domain-containing protein -
CKO49_RS10110 2063810..2064289 - 480 WP_031787688.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13502.79 Da        Isoelectric Point: 10.2892

>T89524 WP_000621178.1 NZ_CP025023:c2059911-2059549 [Staphylococcus argenteus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDNKMKEVDNALMISLGLNTMAHQKN

Download         Length: 363 bp

>T89524 NZ_CP025023:c2059911-2059549 [Staphylococcus argenteus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTTGT
CATTATTCAAAATGACACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCCA
AAATACCGACCCATGTAGAGATTGAAAAGAAAAAATATAAACTGGATAAAGATTCAGTTATATTATTAGAACAAATTCGG
ACACTTGATAAAAAACGTTTAAAAGAAAAACTGACGTACTTATCAGACAACAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTAAACACAATGGCTCATCAGAAAAATTAG

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT89524 WP_000948331.1 NZ_CP025023:c2060078-2059908 [Staphylococcus argenteus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT89524 NZ_CP025023:c2060078-2059908 [Staphylococcus argenteus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCAATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7JQG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References