Detailed information of TA system TA089523

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 2007572..2008110
• Replicon: chromosome
• Accession: NZ_CP025023
• Organism: Staphylococcus argenteus strain XNO106

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: -
• Locus tag: CKO49_RS09810
• Protein ID: WP_031836919.1
• Coordinates: 2007572..2007898 (-)
• Length: 109 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: C5QLS5
• Locus tag: CKO49_RS09815
• Protein ID: WP_001058489.1
• Coordinates: 2007901..2008110 (-)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CKO49_RS09785	2002717..2003058	-	342	WP_001190615.1	hypothetical protein	-
CKO49_RS09790	2003575..2004216	-	642	WP_100848595.1	pathogenicity island protein	-
CKO49_RS09795	2004213..2004593	-	381	WP_000356927.1	hypothetical protein	-
CKO49_RS09800	2004923..2006623	-	1701	WP_000447470.1	DUF927 domain-containing protein	-
CKO49_RS09805	2006637..2007506	-	870	WP_100848596.1	primase alpha helix C-terminal domain-containing protein	-
CKO49_RS09810	2007572..2007898	-	327	WP_031836919.1	DUF1474 family protein	Toxin
CKO49_RS09815	2007901..2008110	-	210	WP_001058489.1	hypothetical protein	Antitoxin
CKO49_RS09820	2008103..2008249	-	147	WP_000784885.1	hypothetical protein	-
CKO49_RS09825	2008246..2008563	-	318	WP_000481967.1	helix-turn-helix domain-containing protein	-
CKO49_RS09830	2008568..2008786	-	219	WP_000153640.1	helix-turn-helix transcriptional regulator	-
CKO49_RS09835	2008959..2009633	+	675	WP_000620857.1	helix-turn-helix transcriptional regulator	-
CKO49_RS09840	2009647..2010819	+	1173	WP_000179346.1	site-specific integrase	-
CKO49_RS09845	2010888..2012504	-	1617	WP_001118817.1	chaperonin GroEL	-
CKO49_RS09850	2012576..2012860	-	285	WP_031787855.1	co-chaperone GroES	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	groEL	1989534..2012860	23326

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-92)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 109 a.a.
• Molecular weight: 13002.40 Da
• Isoelectric Point: 4.3444

>T89523 WP_031836919.1 NZ_CP025023:c2007898-2007572 [Staphylococcus argenteus]
MDWEIKSLFSDLKLLKDSFEDLKDNHGWHFDELYPYEPNHVLNKDELIGEGFSYHERRIHNNQMFDLFHLYIEQFDNIIE
KFYEIEKASSDVSLATESDDAQKLKITE

Nucleotide

• Length: 327 bp

>T89523 NZ_CP025023:c2007898-2007572 [Staphylococcus argenteus]
ATGGATTGGGAAATTAAAAGTTTATTTAGCGATTTAAAGTTGTTGAAAGATAGTTTTGAGGATTTAAAGGATAATCATGG
TTGGCATTTTGATGAGCTATATCCATATGAACCAAATCATGTCTTAAATAAAGATGAATTAATTGGAGAGGGATTTTCTT
ATCATGAGAGACGTATTCACAATAATCAAATGTTTGATTTATTCCATCTCTATATAGAGCAGTTCGATAATATTATCGAA
AAGTTTTATGAAATAGAAAAAGCATCATCTGATGTAAGTTTGGCGACAGAATCAGATGACGCGCAGAAATTAAAAATTAC
AGAGTAA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8225.24 Da
• Isoelectric Point: 4.2820

>AT89523 WP_001058489.1 NZ_CP025023:c2008110-2007901 [Staphylococcus argenteus]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVDGIEVVSEVSREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT89523 NZ_CP025023:c2008110-2007901 [Staphylococcus argenteus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTGTCATGAATAACTTGGAAAGTTA
TGAACACACAGAATATGTTGATGGTATTGAAGTGGTTTCAGAGGTTAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Structures

Antitoxin

• AlphaFold DB: A0A853V601