89458

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DhiAT/dnstrm_HI1420(antitoxin)
Location 1788214..1788967 Replicon chromosome
Accession NZ_CP025003
Organism Dickeya fangzhongdai strain DSM 101947

Toxin (Protein)


Gene name dhiT Uniprot ID A0A2K8QMG8
Locus tag CVE23_RS08095 Protein ID WP_038918519.1
Coordinates 1788214..1788471 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name dhiA Uniprot ID A0A2K8QKC0
Locus tag CVE23_RS08100 Protein ID WP_038918520.1
Coordinates 1788479..1788967 (+) Length 163 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CVE23_RS08085 1784989..1787139 - 2151 WP_049854965.1 formate dehydrogenase subunit alpha -
CVE23_RS08090 1787174..1787716 - 543 WP_100849266.1 4Fe-4S dicluster domain-containing protein -
CVE23_RS08095 1788214..1788471 + 258 WP_038918519.1 DUF4160 domain-containing protein Toxin
CVE23_RS08100 1788479..1788967 + 489 WP_038918520.1 addiction module antitoxin Antitoxin
CVE23_RS08105 1789052..1789549 - 498 WP_038918521.1 hydrogenase maturation peptidase HycI -
CVE23_RS08110 1789542..1789940 - 399 WP_038660229.1 formate hydrogenlyase maturation HycH family protein -
CVE23_RS08115 1789937..1790728 - 792 WP_038918522.1 NADH-quinone oxidoreductase subunit B family protein -
CVE23_RS08120 1790725..1791294 - 570 WP_039691199.1 hydrogenase 4 subunit H -
CVE23_RS08125 1791305..1793032 - 1728 WP_038918525.1 hydrogenase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin

Uncharacterized protein HI1420

(79-157)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9977.52 Da        Isoelectric Point: 8.1489

>T89458 WP_038918519.1 NZ_CP025003:1788214-1788471 [Dickeya fangzhongdai]
MPEIDRLAGLIFHLYFYDDERHHLPHVHVCYGNHELIISIRTGTEIEGYLPNNKRKLALAHIRAHREQLLSMWERAVVGR
NPGKL

Download         Length: 258 bp

>T89458 NZ_CP025003:1788214-1788471 [Dickeya fangzhongdai]
ATGCCTGAGATTGACAGACTGGCAGGGCTGATTTTCCATTTGTACTTTTACGATGATGAACGGCACCACTTGCCGCACGT
TCATGTCTGTTATGGCAACCATGAGCTGATCATCAGTATTCGTACTGGAACAGAGATCGAAGGATATCTGCCGAATAACA
AGCGCAAGCTGGCGCTTGCGCATATCAGAGCCCATCGGGAACAACTGCTGAGTATGTGGGAGCGGGCGGTTGTGGGGAGA
AATCCGGGAAAACTGTGA

Antitoxin


Download         Length: 163 a.a.        Molecular weight: 17940.51 Da        Isoelectric Point: 6.9795

>AT89458 WP_038918520.1 NZ_CP025003:1788479-1788967 [Dickeya fangzhongdai]
MHKIVEVDVIGDFSLRLTYEDGLVCDINLYQYASSPVFSNASLFIKFGLLPDGSLEWSPDIKISASELRKKGEYVSHTLA
VREKNFADVISRAFYDAVIENRPEILQAALKIAVEKHGNSTVAKEAGAKSRTSLYKSLNKNTHVSLATVVSLAHTVLQLE
EK

Download         Length: 489 bp

>AT89458 NZ_CP025003:1788479-1788967 [Dickeya fangzhongdai]
ATGCATAAAATCGTGGAAGTTGACGTGATTGGCGACTTTTCGTTGCGCCTGACCTATGAGGATGGTTTGGTTTGCGACAT
CAATCTTTATCAATATGCCTCCAGCCCGGTATTTTCGAACGCCAGCCTATTTATCAAGTTTGGGCTGCTGCCGGATGGTT
CGCTGGAATGGTCGCCGGATATTAAGATTTCCGCGTCGGAATTGCGGAAAAAAGGGGAGTATGTCAGCCACACGCTTGCG
GTGCGAGAAAAGAACTTCGCTGATGTCATCTCTCGCGCCTTCTATGATGCCGTGATTGAGAACCGGCCGGAAATTCTGCA
AGCGGCGTTGAAAATCGCGGTGGAAAAACATGGCAACAGCACAGTAGCCAAAGAGGCGGGGGCGAAAAGTCGCACCAGTC
TGTATAAGTCGCTGAATAAAAATACCCATGTCAGTCTTGCGACGGTGGTCAGCCTGGCGCATACCGTGCTGCAACTGGAA
GAGAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K8QMG8

Antitoxin

Source ID Structure
AlphaFold DB A0A2K8QKC0

References