Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1315831..1316456 Replicon chromosome
Accession NZ_CP025003
Organism Dickeya fangzhongdai strain DSM 101947

Toxin (Protein)


Gene name Hha Uniprot ID E0SD87
Locus tag CVE23_RS06090 Protein ID WP_009114000.1
Coordinates 1315831..1316034 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A2K8QJA5
Locus tag CVE23_RS06095 Protein ID WP_042859087.1
Coordinates 1316088..1316456 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CVE23_RS06060 1311470..1311808 + 339 WP_002208627.1 P-II family nitrogen regulator -
CVE23_RS06065 1311851..1313143 + 1293 WP_038661206.1 ammonium transporter AmtB -
CVE23_RS06070 1313236..1314099 - 864 WP_100849114.1 acyl-CoA thioesterase II -
CVE23_RS06075 1314352..1314912 + 561 WP_049854165.1 YbaY family lipoprotein -
CVE23_RS06080 1314941..1315270 - 330 WP_100849115.1 MGMT family protein -
CVE23_RS06090 1315831..1316034 - 204 WP_009114000.1 hemolysin expression modulator Hha Toxin
CVE23_RS06095 1316088..1316456 - 369 WP_042859087.1 Hha toxicity modulator TomB Antitoxin
CVE23_RS06100 1316964..1317107 - 144 WP_013316871.1 type B 50S ribosomal protein L36 -
CVE23_RS06105 1317123..1317374 - 252 WP_038661187.1 type B 50S ribosomal protein L31 -
CVE23_RS06110 1317545..1320691 - 3147 WP_038918200.1 multidrug efflux RND transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8133.51 Da        Isoelectric Point: 8.8500

>T89457 WP_009114000.1 NZ_CP025003:c1316034-1315831 [Dickeya fangzhongdai]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFYSAADHRLAELTMNKLYDKVPTAVWKYVR

Download         Length: 204 bp

>T89457 NZ_CP025003:c1316034-1315831 [Dickeya fangzhongdai]
ATGAAAAAAATCGACTATTTAATGCGTTTGCGTAAATGCACAACCATCGACACGCTTGAGCGTGTTATAGAAAAAAACAA
GTACGAGCTTTCCAACGATGAGCTTGAAATGTTCTATTCAGCTGCAGACCACCGCCTGGCAGAGCTGACGATGAATAAGC
TTTACGACAAAGTACCAACTGCTGTGTGGAAATACGTTCGTTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14200.07 Da        Isoelectric Point: 5.1811

>AT89457 WP_042859087.1 NZ_CP025003:c1316456-1316088 [Dickeya fangzhongdai]
MDEYTPQHYDIAQLRFLCENLHDESIATLGDSSRGWVNDPTSAVNLQLNELIEHIAAFVVTYKIKYPHEAALCERVEKYL
DDTYILFSNYGINDSELQKWKKSKSQLFRMFSEKSICTVVKT

Download         Length: 369 bp

>AT89457 NZ_CP025003:c1316456-1316088 [Dickeya fangzhongdai]
ATGGATGAGTACACACCTCAACATTATGATATTGCCCAACTCAGATTCTTGTGTGAAAATCTGCACGACGAAAGTATCGC
GACATTAGGTGACAGCAGTCGTGGCTGGGTGAATGATCCGACCTCTGCGGTCAACCTTCAACTAAACGAACTTATCGAGC
ATATTGCGGCATTTGTTGTTACCTACAAAATAAAATACCCGCATGAAGCGGCGTTATGTGAACGGGTTGAGAAATATCTG
GACGACACTTATATTCTTTTCAGCAATTACGGTATAAATGACTCCGAGTTGCAGAAATGGAAAAAATCCAAGTCACAATT
ATTCAGAATGTTCTCAGAAAAGAGCATCTGTACGGTAGTAAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X3RNQ0

Antitoxin

Source ID Structure
AlphaFold DB A0A2K8QJA5

References